The Discovery of Vitamin D: The Contribution of Adolf Windaus

Wolf, George

doi:10.1093/jn/134.6.1299

Cited by 139 publications

(95 citation statements)

References 30 publications

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“…It is a secosteroid and is primarily responsible for maintaining calcium homeostasis by facilitating absorption and utilization of minerals; as a result, it acts as a major contributor toward bone formation and homeostasis (15,(20)(21)(22)(23)(24). The naturally occurring form of vitamin D is biologically inactive and requires hydroxylation in the liver and kidney for activation (25).…”

Section: Vitamin D and Its Biological Rolementioning

confidence: 99%

Vitamin D and Multiple Sclerosis: An Update

Zahoor

Haq

2017

Multiple Sclerosis: Perspectives in Treatment and Pathogenesis

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Multiple sclerosis (MS) is a long-lasting inflammatory neurodegenerative disease of the central nervous system caused by an inappropriate attack of the body' s immune system on its own cells. To date, its etiology remains highly enigmatic, with insufficient evidence on the exact cause triggering the disease. Many studies have highlighted the role of different environmental and genetic factors in its etiopathogenesis, each adding a new wedge to MS conundrum and therefore making it a multifactorial and polygenic disease. One of the entrants in the risk factor category for MS is vitamin D, and there is sufficient evidence to suggest its role in increasing the risk of MS development. MS patients have lower levels of vitamin D, and in conjunction with other factors like low sunlight intensity and genetic variations in vitamin D metabolic pathway genes, vitamin D has been adjudged as a potent risk factor for MS. The biological effects of vitamin D in the body are mediated by the vitamin D receptor that acts as a transcription factor after activation by vitamin D and subsequent heterodimerization with the retinoid-X receptor. This allows regulation of protein expression of target genes involved in diverse cellular processes including immune response and vitamin D metabolism. It clearly suggests use of vitamin D supplementation as an unconventional option for MS treatment; however, much work needs to be done to precisely determine the level and/or dosage of vitamin D required for achieving optimum therapeutic response in patients without causing adverse effects.

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Section: Vitamin D and Its Biological Rolementioning

confidence: 99%

Vitamin D and Multiple Sclerosis: An Update

Zahoor

Haq

2017

Multiple Sclerosis: Perspectives in Treatment and Pathogenesis

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“…Although Adolf Windaus discovered vitamin D in the 1930s (1), it is by far the oldest "hormone" on the planet, from an evolutionary point of view. It is now clear that organisms known to have lived millions of years ago synthesized vitamin D when exposed to the sun's ultraviolet-B radiation (290-315 nm) (2).…”

Section: Vitamin D: More Than Just a Vitaminmentioning

confidence: 99%

Vitamin D Deficiency and Cardiovascular Disease: Potential Mechanisms and Novel Perspectives

Maaty

2013

J Nutr Sci Vitaminol

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Summary Interest in contemporary vitamin D research has been sparked in recent years, stemming from the identification of vitamin D receptors in virtually all cells as well as the enzymatic machinery necessary to produce its active form. Both epidemiological and invitro studies have linked vitamin D deficiency to enigmatic diseases including cardiovascular disease; however, a clear mechanistic link remains missing. This review highlights conclusions of observational studies, in-vitro experiments and randomized-controlled trials that aimed to link deficiency of the sunshine vitamin to one of the leading causes of death in the world, cardiovascular disease. Furthermore, putative mechanisms viewed from a novel perspective are also discussed.

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“…Vitamin D was discovered in early 20th century while looking for a cure for rickets [1]. British doctor Edward Mellan [2] by noticed dogs that were fed cod liver oil did not develop rickets and concluded vitamin A, or a closely associated factor, could prevent the disease.…”

Section: Introductionmentioning

confidence: 99%

Non Calcaemic & Non Osteogenic Functions of Vitamin D: A Brief Review

Behera

2018

MOJAP

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Vitamin D insufficiency affects almost 50% of the population worldwide. This can mainly be attributed to lifestyle (for example, reduced outdoor activities, liberal use of sunscreen) and environmental (for example, air pollution) factors that reduce exposure to sunlight, which is vital for ultraviolet-B (UVB)-induced vitamin D production. Vitamin D deficiency is common in all age groups. High prevalence of vitamin D insufficiency is a particularly important public health issue as Hypovitaminosis-D is an independent risk factor for several non communicable & communicable diseases. Current studies suggest that we may need more vitamin D than presently recommended to prevent chronic disease like Diabetes & Hypertension. Present review focuses on the non-calcemic and non-osteogenic role of Vitamin D and how Vitamin D deficiency might be an important risk factor in increased disease incidence & prevalence.

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The Discovery of Vitamin D: The Contribution of Adolf Windaus

Cited by 139 publications

References 30 publications

Vitamin D and Multiple Sclerosis: An Update

Vitamin D and Multiple Sclerosis: An Update

Vitamin D Deficiency and Cardiovascular Disease: Potential Mechanisms and Novel Perspectives

Non Calcaemic & Non Osteogenic Functions of Vitamin D: A Brief Review

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