Glycosaminoglycans and vitamin C in ovo feeding affects bone characteristics of chicks

Santos, Elaine Talita; Sgavioli, Sarah; Castiblanco, Diana Maryuri Correa; Domingues, Carla Heloísa de Faria; Quadros, Thays Cristina Oliveira de; Borges, Liliana Longo; Petrolli, Tiago Goulart; Artoni, Silvana Martinez Baraldi

doi:10.1590/rbz4720170304

Cited by 8 publications

(7 citation statements)

References 26 publications

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“…Polysulfated glycosaminoglycans have prevented and/or reduced the progression of pathologic changes in bone and joint structures of animal models such as rats ( Wen et al., 2010 ; Chiusaroli et al., 2011 ; Jawed et al., 2011 ; Muraleva et al., 2012 ; Arafa et al., 2013 ; Wolff, 2014 ), rabbits ( Herrero-Beaumont et al., 2008 ; Largo et al., 2010 ; Kamarul et al., 2011 ), dogs ( Vieira et al., 2010 ; Eleotéreo et al., 2012 ; Gupta et al., 2012 ; Maxwell et al., 2016 ; Wenz et al., 2017 ), broiler chickens ( Sgavioli et al., 2017 ; Santos et al., 2018 , 2019 ), humans ( Kahan et al., 2009 ; Wildi et al., 2011 ; Kantor et al., 2014 ; Lubis et al., 2017 ), and in vitro ( Tat et al., 2007 ; Varghese et al., 2007 ; Uitterlinden et al., 2008 ; Calamia et al., 2010 , 2012 , 2014 ; Chiusaroli et al., 2011 ; Imagawa et al., 2011 ; Pecchi et al., 2012 ; Cunha et al., 2017 ; Igarashi et al., 2017 ; Kim et al., 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Dietary supplementation with glycosaminoglycans reduces locomotor problems in broiler chickens

et al. 2020

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This study aimed to assess the influence of glycosaminoglycan (chondroitin and glucosamine sulfates) supplementation in the diet on the performance and incidence of locomotor problems in broiler chickens. A completely randomized design was carried out in a 3 × 3 factorial scheme (3 levels of chondroitin sulfate −0, 0.05, and 0.10%; and 3 levels of glucosamine sulfate −0, 0.15, and 0.30%). Each treatment was composed of 6 replications of 30 broilers each. The performance of broilers (average weight, weight gain, feed intake, feed conversion, and productive viability) was assessed at 7, 21, 35, and 42 d of age, whereas the gait score, valgus and varus deviations, femoral degeneration, and tibial dyschondroplasia were assessed at 21 and 42 d of age. Increasing levels of glucosamine sulfate inclusion linearly increased the weight gain from 1 to 35 and from 1 to 42 d of age of broilers ( P = 0.047 and P = 0.039, respectively), frequency of broilers with no femoral degeneration in the right and left femurs, and the proliferating cartilage area of proximal epiphysis at 42 d of age ( P = 0.014, P < 0.0001, and P = 0.028, respectively). The increasing inclusion of chondroitin and glucosamine sulfates led to an increase in the frequency of broilers on the gait score scale 0 ( P = 0.007 and P = 0.0001, respectively) and frequency of broilers with no valgus and varus deviations ( P = 0.014 and P = 0.0002, respectively) also at 42 d of age. Thus, chondroitin and glucosamine sulfates can be used in the diet of broiler chickens to reduce their locomotor problems.

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Section: Introductionmentioning

confidence: 99%

Dietary supplementation with glycosaminoglycans reduces locomotor problems in broiler chickens

et al. 2020

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“…Polysulfated glycosaminoglycans (GAG), chondroitin, and glucosamine have been studied as nutraceuticals in the prevention and/or treatment of pathologies of bone and joint structures in broilers (Sgavioli et al, 2017;Santos et al, 2018;Santos et al, 2019). Chondroitin sulfate is composed of hexosamine D-galactosamine and D-glucuronic acid.…”

Section: Introductionmentioning

confidence: 99%

Performance, nutrient digestibility, and intestinal histomorphometry of broilers fed diet supplemented with chondroitin and glucosamine sulfates

Martins¹,

Neto²,

Gomides³

et al. 2020

Revista Brasileira De Zootecnia

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Non-ruminants Full-length research article Performance, nutrient digestibility, and intestinal histomorphometry of broilers fed diet supplemented with chondroitin and glucosamine sulfates ABSTRACT-We aimed to evaluate the performance, nutrient digestibility, and intestinal histomorphometry of broilers fed diet supplemented with chondroitin sulfate and glucosamine sulfate. The experiment was carried out with 320 male broiler chicks distributed in a completely randomized design in a 2×2 factorial scheme (0 and 0.1% chondroitin sulfate and 0 and 0.3% glucosamine sulfate), with eight replications of 10 birds. Performance was evaluated at 7 and 21 days of age, nutrient digestibility of the diet was performed from 18 to 21 days of age, and small intestine histomorphometry was evaluated at 21 days of age. Broilers fed diet supplemented with 0.3% glucosamine sulfate showed high final weight and weight gain. A significant interaction was observed between sulfates for digestibility coefficients of nitrogen, mineral matter, and calcium. The use of 0.1% chondroitin sulfate without glucosamine sulfate resulted in a reduced digestibility of nitrogen but increased digestibility of total minerals and calcium. Diets without chondroitin sulfate with 0.3% glucosamine sulfate increased the digestibility coefficients of mineral matter and calcium. A significant interaction was found for jejunum villus height, which was higher in broilers fed diet supplemented with 0.3% glucosamine sulfate, regardless of the inclusion of chondroitin sulfate. Thus, supplementation with glucosamine sulfate in broiler diets contributes to high weight gain and villus height. Sulfates used in isolation promote high digestibility of minerals.

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“…The association of chondroitin and glucosamine sulfates has a proven effect on the bone and cartilaginous development of broilers (Santos et al, 2018(Santos et al, , 2019Sgavioli et al, 2017), consequently preventing locomotor problems (Martins et al, 2020b) and improving performance (Martins et al, 2020b;Martins et al, 2020a;Sgavioli et al, 2017). However, no studies have been done on the hematology and serum biochemistry of broilers fed diets containing GAGs.…”

Section: Amongmentioning

confidence: 99%

Hematologia e bioquímica sérica de frangos de corte suplementados com sulfatos de condroitina e de glucosamina na ração

et al. 2023

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Objetivou-se avaliar a hematologia e a bioquímica sérica de frangos de corte suplementados com sulfatos de condroitina e de glucosamina na ração. Foi conduzido um experimento em delineamento inteiramente casualizado, em esquema fatorial 3 x 3 (três níveis de sulfato de condroitina: 0; 0,05 e 0,10%; e três níveis de sulfato de glucosamina: 0; 0,15 e 0,30%), cada tratamento com seis repetições de 30 aves. Foram avaliadas as variáveis de hematologia (hemácias, hemoglobina, hematócrito, proteínas plasmáticas totais [PPT], trombócitos, leucócitos, eosinófilos, monócitos, heterofilos e linfócitos) e bioquímica sérica (proteínas séricas totais [PST], albumina, globulinas, aspartato aminotransferase [AST], gama glutamiltransferase [GGT], fosfatase alcalina [FA], cálcio total, cálcio iônico, fósforo, sódio, potássio e cloretos) aos 21 e 42 dias. Os dados foram submetidos à análise de variância. Quando as médias diferiram significativamente pelo teste F, a análise ortogonal foi realizada para testar os efeitos lineares e quadráticos dos níveis dos sulfatos de condroitina e de glucosamina. Observou-se efeito linear decrescente (p = 0,0399) do sulfato de glucosamina na quantidade de monócitos aos 42 dias. Houve interação dos sulfatos para leucócitos totais (p = 0,0099) e linfócitos (p = 0,0004) aos 21 dias. Frangos suplementados com 0,10% de sulfato de condroitina mostraram um aumento linear dos leucócitos (p = 0,0287) e dos linfócitos (p = 0,0144) com a inclusão de sulfato de glucosamina. A suplementação com sulfato de condroitina aumentou linearmente (p = 0,0099) a albumina sérica e afetou de forma quadrática (p = 0,0140) as PST aos 21 dias. O sulfato de glucosamina demonstrou um efeito quadrático (p < 0,05) sobre a albumina aos 42 dias, o menor valor foi encontrado para a inclusão de 0,06%, respectivamente. O sulfato de glucosamina reduziu linearmente (p = 0,0237) os cloretos aos 21 dias e aumentou linearmente (p = 0,0012) o cálcio total aos 42 dias. Verificouse interação (p < 0,05) dos sulfatos para cálcio total aos 21 dias, cálcio iônico aos 21 e 42 dias e para fósforo, cloretos e sódio aos 42 dias. A suplementação com os sulfatos de condroitina e de glucosamina na ração de frangos de corte favoreceram o sistema imune e o metabolismo de minerais, com aumento nas concentrações séricas de cálcio, fósforo e sódio.

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Glycosaminoglycans and vitamin C in ovo feeding affects bone characteristics of chicks

Cited by 8 publications

References 26 publications

Dietary supplementation with glycosaminoglycans reduces locomotor problems in broiler chickens

Dietary supplementation with glycosaminoglycans reduces locomotor problems in broiler chickens

Performance, nutrient digestibility, and intestinal histomorphometry of broilers fed diet supplemented with chondroitin and glucosamine sulfates

Hematologia e bioquímica sérica de frangos de corte suplementados com sulfatos de condroitina e de glucosamina na ração

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