Glycoside oleandrin downregulates toll-like receptor pathway genes and associated miRNAs in human melanoma cells

Güneş, Canan Eroğlu; Çelik, Fatma Seçer; Seçme, Mücahit; Elmas, Levent; Dodurga, Yavuz; Kurar, Ercan

doi:10.1016/j.gene.2022.146805

Cited by 5 publications

(2 citation statements)

References 42 publications

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“…This was corroborated by the Western blot results in which the expression of phospho-PERK and its downstream proteins phospho-eIF2α, ATF4, and CHOP increased after oleandrin treatment [63]. Oleandrin also had pro-apoptotic effects against several other cell lines, including SW480, HCT116, RKO, A375, GL261, and U87MG cells [62,64]. It was reported that DNA damage induction contributes to the pro-apoptotic effects of oleandrin.…”

Section: Apoptosismentioning

confidence: 58%

Steroidal Saponins: Naturally Occurring Compounds as Inhibitors of the Hallmarks of Cancer

Bouabdallah,

Al-Maktoum,

Amin

2023

Cancers

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Cancer is a global health burden responsible for an exponentially growing number of incidences and mortalities, regardless of the significant advances in its treatment. The identification of the hallmarks of cancer is a major milestone in understanding the mechanisms that drive cancer initiation, development, and progression. In the past, the hallmarks of cancer have been targeted to effectively treat various types of cancers. These conventional cancer drugs have shown significant therapeutic efficacy but continue to impose unfavorable side effects on patients. Naturally derived compounds are being tested in the search for alternative anti-cancer drugs. Steroidal saponins are a group of naturally occurring compounds that primarily exist as secondary metabolites in plant species. Recent studies have suggested that steroidal saponins possess significant anti-cancer capabilities. This review aims to summarize the recent findings on steroidal saponins as inhibitors of the hallmarks of cancer and covers key studies published between the years 2014 and 2024. It is reported that steroidal saponins effectively inhibit the hallmarks of cancer, but poor bioavailability and insufficient preclinical studies limit their utilization.

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Section: Apoptosismentioning

confidence: 58%

Steroidal Saponins: Naturally Occurring Compounds as Inhibitors of the Hallmarks of Cancer

Bouabdallah,

Al-Maktoum,

Amin

2023

Cancers

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“…Furthermore, PBI and oleandrin enhanced immune cell activation in response to a viral mimetic challenge, using synthetic double-stranded RNA to engage Toll-Like receptor-3 (TLR-3) on immune cells [ 29 ]. The expression of the activation markers, CD25 and CD69, on NK cells and monocytes was increased in cultures challenged with Poly I:C, when compared to cultures treated with test products only.…”

Section: Discussionmentioning

confidence: 99%

Differential Activities of the Botanical Extract PBI-05204 and Oleandrin on Innate Immune Functions under Viral Challenge Versus Inflammatory Culture Conditions

Jensen,

Yu,

Iloba

et al. 2023

Molecules

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The Nerium oleander extract PBI 05204 (PBI) and its cardiac glycoside constituent oleandrin have direct anti-viral properties. Their effect on the immune system, however, is largely unknown. We used an in vitro model of human peripheral blood mononuclear cells to document effects under three different culture conditions: normal, challenged with the viral mimetic polyinosinic:polycytidylic acid Poly I:C, and inflamed by lipopolysaccharide (LPS). Cells were evaluated for immune activation marks CD69, CD25, and CD107a, and culture supernatants were tested for cytokines. Both PBI and oleandrin directly activated Natural Killer (NK) cells and monocytes and triggered increased production of cytokines. Under viral mimetic challenge, PBI and oleandrin enhanced the Poly I:C-mediated immune activation of monocytes and NK cells and enhanced production of IFN-γ. Under inflammatory conditions, many cytokines were controlled at similar levels as in cultures treated with PBI and oleandrin without inflammation. PBI triggered higher levels of some cytokines than oleandrin. Both products increased T cell cytotoxic attack on malignant target cells, strongest by PBI. The results show that PBI and oleandrin directly activate innate immune cells, enhance anti-viral immune responses through NK cell activation and IFN-γ levels, and modulate immune responses under inflamed conditions. The potential clinical impact of these activities is discussed.

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Investigation of the TLR4 and IRF3 signaling pathway-mediated effects of monensin in colorectal cancer cells

Seçme

Koçoğlu

2023

Med Oncol

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Glycoside oleandrin downregulates toll-like receptor pathway genes and associated miRNAs in human melanoma cells

Cited by 5 publications

References 42 publications

Steroidal Saponins: Naturally Occurring Compounds as Inhibitors of the Hallmarks of Cancer

Steroidal Saponins: Naturally Occurring Compounds as Inhibitors of the Hallmarks of Cancer

Differential Activities of the Botanical Extract PBI-05204 and Oleandrin on Innate Immune Functions under Viral Challenge Versus Inflammatory Culture Conditions

Investigation of the TLR4 and IRF3 signaling pathway-mediated effects of monensin in colorectal cancer cells

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