Glycosidic constituents from the roots and rhizomes of Melicope pteleifolia

Zhang, Yang; Yang, Lijun; Jiang, Kun; Tan, Chang‐Heng; Tan, Jacqueline; Yang, Peng; Zhu, Dunming

doi:10.1016/j.carres.2012.08.011

Cited by 20 publications

(16 citation statements)

References 22 publications

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“…In Vietnamese traditional medicine, the extract prepared from M. pteleifolia, under the local name of "Ba chac", is empirically used for the treatment of high fevers, colds and various inflammatory conditions. Previous phytochemical investigations established that the main constituents of this plant were benzopyrans (Guo-Lin et al, 1997;Kamperdick et al, 1997), furoquinoline alkaloids (Sichaem et al, 2014) and glycosidic compounds (Zhang et al, 2012). It was also found that the methanol extract from its leaves and twigs exhibited anti-inflammatory activities through either 5-lipoxygenase (5-LOX) inhibition (Shaari et al, 2011) or interactions with Syk/Src targets (Yoon et al, 2013), which are ethnopharmacologically relevant for its traditional usage.…”

Section: Introductionmentioning

confidence: 94%

Chemical constituents from Melicope pteleifolia leaves

Nguyen

Choi

et al. 2016

Phytochemistry

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Section: Introductionmentioning

confidence: 94%

Chemical constituents from Melicope pteleifolia leaves

Nguyen

Choi

et al. 2016

Phytochemistry

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“…Previous studies have indicated that three types of compounds, including phenolic acids, flavonoids and iridoids, are responsible for the overall therapeutic effects of Jinyinhua as well as Mujinggen [3,4,5,6,7,8,9]. However, relatively little research has been done in regard to the chemical constituents and pharmacological effects of the other herbal ingredients in YHKGT [10,11,12].…”

Section: Introductionmentioning

confidence: 99%

Qualitative and Quantitative Analysis of Phenolic Acids, Flavonoids and Iridoid Glycosides in Yinhua Kanggan Tablet by UPLC-QqQ-MS/MS

Huang

et al. 2015

Molecules

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A simple, rapid and specific ultra-performance liquid chromatography-triple quadrupole mass spectrometry method was developed for the analysis of 29 bioactive components (10 phenolic acids, 16 flavonoids, and three iridoid glycosides) in Yinhua Kanggan tablet (YHKGT), a herbal prescription used for treating upper respiratory infections, fevers, coughs and pharyngalgia. The separation was successfully achieved using a Waters Cortecs UPLC C18 column (50 × 2.1 mm, 1.6 μm) and gradient elution with water-0.1% formic acid and acetonitrile. Polarity switching mode was used in the optimization of multiple reaction monitoring conditions. The analytical method was validated for linearity, precision and accuracy. Calibration curves for the 29 marker compounds showed good linear regression (r > 0.9982). The limits of detection (LOD) and limits of quantification (LOQ) for the 29 analytes were in the range of 0.03-4.99 ng/mL and 0.16-14.87 ng/mL, respectively. The relative standard deviation (RSD) values of intra-day precision, inter-day precision, repeatability, and stability were less than 2.79%, 4.87%, 4.18% and 4.71%, respectively. The recoveries of the 29 marker compounds were in the range of 94.67%-104.78% (RSD ≤ 4.72%). These results have shown that this developed method was efficient for the quality evaluation of YHKGT.

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“…2), clearly confirmed the planar structure of 1. The S configuration at C-9 was determined by using the empirical rules of 13 (C-10), and 102.0−102.9 (C-1′). 10) In addition, the absolute configuration at C-6 was elucidated as S by a good agreement of the electronic circular dichroism (ECD) data of 1 in MeOH (with a negative Cotton effect at 279 nm and a positive effect at 241 nm) and schinifolenol A in MeOH (with a negative Cotton effect at 270 nm and a positive effect at 235 nm) 11) as well as comparison of its experimental ECD spectrum with those calculated for both 6R and 6S isomers of the aglycon of 1 (Fig.…”

Section: Resultsmentioning

confidence: 99%

Chemical Constituents from the Branches and Leaves of <i>Alchornea trewioides</i>

Phan

Thuan

Duyen

et al. 2021

CHEMICAL & PHARMACEUTICAL BULLETIN

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Two new megastigmane glucosides namely trewiosides A (1) and B (2), along with 20αhydroxypregn-4-en-3-one β-D-glucopyranoside (3), sugeroside (4), and schizandriside (5) were isolated from the branches and leaves of Alchornea trewioides. The structure elucidation was confirmed by extensive analysis of the 1D and 2D NMR, electronic circular dichroism (ECD) as well as high resolution electrospray ionization quadrupole time-of-flight (HR-ESI-QTOF) mass spectra. Noteworthily, the isolation of compounds 1 and 2 represents the second finding of megastigmane derivatives with a methoxycarbonyl group at C-5 to date. In addition, compound 3 showed weak cytotoxicity against three human cancer cell lines as A549 (lung carcinoma), HepG2 (hepatocarcinoma), and MCF7 (breast carcinoma). Besides, compounds 2 and 3 exhibited moderate inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells. Whereas, the remaining compounds 1, 4 and 5 showed weak inhibitory activity.

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Glycosidic constituents from the roots and rhizomes of Melicope pteleifolia

Cited by 20 publications

References 22 publications

Chemical constituents from Melicope pteleifolia leaves

Chemical constituents from Melicope pteleifolia leaves

Qualitative and Quantitative Analysis of Phenolic Acids, Flavonoids and Iridoid Glycosides in Yinhua Kanggan Tablet by UPLC-QqQ-MS/MS

Chemical Constituents from the Branches and Leaves of <i>Alchornea trewioides</i>

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