Glycyrrhizic Acid Prevents Diabetic Nephropathy by Activating AMPK/SIRT1/PGC-1<i>α</i> Signaling in db/db Mice

Hou, Shaozhang; Zhang, Ting; Li, Yuan; Guo, Fengying; Jin, Xin

doi:10.1155/2017/2865912

Cited by 48 publications

(30 citation statements)

References 47 publications

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“…Containing the key phytochemical GA, licorice is generally associated with detoxication in TCM [56], and exhibits antiviral effect [57][58][59]. Others have found that GA activates SIRT1 in diabetic db/db mice [60] and increases the expression of SIRT1 in renal tubular epithelial cell line [61]. Hence, it is speculated that GA may exert anti-CoV effects via regulating SIRT 1 protein.…”

Section: Discussionmentioning

confidence: 99%

A Novel Combination of Vitamin C, Curcumin and Glycyrrhizic Acid Potentially Regulates Immune and Inflammatory Response Associated with Coronavirus Infections: A Perspective from System Biology Analysis

Chen¹,

Hu²,

Hood

et al. 2020

Nutrients

119

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Novel coronaviruses (CoV) have emerged periodically around the world in recent years. The recurrent spreading of CoVs imposes an ongoing threat to global health and the economy. Since no specific therapy for these CoVs is available, any beneficial approach (including nutritional and dietary approach) is worth investigation. Based on recent advances in nutrients and phytonutrients research, a novel combination of vitamin C, curcumin and glycyrrhizic acid (VCG Plus) was developed that has potential against CoV infection. System biology tools were applied to explore the potential of VCG Plus in modulating targets and pathways relevant to immune and inflammation responses. Gene target acquisition, gene ontology and Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment were conducted consecutively along with network analysis. The results show that VCG Plus can act on 88 hub targets which are closely connected and associated with immune and inflammatory responses. Specifically, VCG Plus has the potential to regulate innate immune response by acting on NOD-like and Toll-like signaling pathways to promote interferons production, activate and balance T-cells, and regulate the inflammatory response by inhibiting PI3K/AKT, NF-κB and MAPK signaling pathways. All these biological processes and pathways have been well documented in CoV infections studies. Therefore, our findings suggest that VCG Plus may be helpful in regulating immune response to combat CoV infections and inhibit excessive inflammatory responses to prevent the onset of cytokine storm. However, further in vitro and in vivo experiments are warranted to validate the current findings with system biology tools. Our current approach provides a new strategy in predicting formulation rationale when developing new dietary supplements.

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Section: Discussionmentioning

confidence: 99%

A Novel Combination of Vitamin C, Curcumin and Glycyrrhizic Acid Potentially Regulates Immune and Inflammatory Response Associated with Coronavirus Infections: A Perspective from System Biology Analysis

Chen¹,

Hu²,

Hood

et al. 2020

Nutrients

119

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show abstract

“…We also showed that puerarin, an extract from a Chinese herbal medicine, attenuates diabetic kidney injury through activation of SIRT1 and suppression of NOX4 expression in podocytes in experimental diabetic mouse model ( 62 ). Other herbal medicines or compounds have also been reported to improve DKD through activation of SIRT1 ( 36 , 38 ). Metformin is reported to improve podocyte function by activating SIRT1 ( 66 ).…”

Section: Sirt1 Is a Potential Drug Target For Treatment Of Dkdmentioning

confidence: 99%

SIRT1 Is a Potential Drug Target for Treatment of Diabetic Kidney Disease

Zhong

Lee

2018

Front. Endocrinol.

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Multiple studies have demonstrated a critical role of Sirtuin-1 (SIRT1) deacetylase in protecting kidney cells from cellular stresses. A protective role of SIRT1 has been reported in both podocytes and renal tubular cells in multiple kidney disease settings, including diabetic kidney disease (DKD). We and others have shown that SIRT1 exerts renoprotective effects in DKD in part through the deacetylation of transcription factors involved in the disease pathogenesis, such as p53, FOXO, RelA/p65NF-κB, STAT3, and PGC1α/PPARγ. Recently we showed that the podocyte-specific overexpression of SIRT1 attenuated proteinuria and kidney injury in an experimental model of DKD, further confirming SIRT1 as a potential target to treat kidney disease. Known agonists of SIRT1 such as resveratrol diminished diabetic kidney injury in several animal models. Similarly, we also showed that puerarin, a Chinese herbal medicine compound, activates SIRT1 to provide renoprotection in mouse models of DKD. However, as these are non-specific SIRT1 agonists, we recently developed a more specific and potent SIRT1 agonist (BF175) that significantly attenuated diabetic kidney injury in type 1 diabetic OVE26 mice. We also previously reported that MS417, a bromodomain inhibitor that disrupts the interaction between the acetyl-residues of NF-κB and bromodomain-containing protein 4 (BRD4) also attenuates DKD. These results suggest that SIRT1 agonists and bromodomain inhibitors could be potential new therapuetic treatments against DKD progression.

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“…It mainly consists of triterpenes and flavonoids [4]. Glycyrrhizic acid and liquiritin are known as the main bioactive compounds in licorice in anti‐inflammation [5], preventing cancer [6,7], diabetic nephropathy [8], and hyperprolactinemia‐associated disorders [9]. The contents of glycyrrhizic acid and liquiritin varied from geographical origins [10,11].…”

Section: Introductionmentioning

confidence: 99%

Metabolomics study of different parts of licorice from different geographical origins and their anti‐inflammatory activities

Bai

Bao

Xiu

et al. 2020

J of Separation Science

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Glycyrrhiza uralensis Fisch., known as licorice, is one of the most famous traditional Chinese medicines. In this study, we perform a metabolome analysis using liquid chromatography-tandem mass spectrometry to assign bioactive components in different parts of licorice from different geographical origins in Gansu province of China. Sixteen potential biomarkers of taproots from different geographical origins were annotated, such as glycycoumarin, gancaonin Z, licoricone, and dihydroxy kanzonol H mainly exist in the sample of Jiuquan; neoliquiritin, 6 ′ -acetylliquiritin, licochalcone B, isolicoflavonol, glycyrol, and methylated uralenin mainly exist in Glycyrrhiza uralensis from Lanzhou; gancaonin L, uralenin, and glycybridin I mainly exist in licorice from Wuwei for the first time. K E Y W O R D Santi-inflammatory activity, geographical origin, licorice, metabolomics, traditional Chinese medicine

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Glycyrrhizic Acid Prevents Diabetic Nephropathy by Activating AMPK/SIRT1/PGC-1α Signaling in db/db Mice

Cited by 48 publications

References 47 publications

A Novel Combination of Vitamin C, Curcumin and Glycyrrhizic Acid Potentially Regulates Immune and Inflammatory Response Associated with Coronavirus Infections: A Perspective from System Biology Analysis

A Novel Combination of Vitamin C, Curcumin and Glycyrrhizic Acid Potentially Regulates Immune and Inflammatory Response Associated with Coronavirus Infections: A Perspective from System Biology Analysis

SIRT1 Is a Potential Drug Target for Treatment of Diabetic Kidney Disease

Metabolomics study of different parts of licorice from different geographical origins and their anti‐inflammatory activities

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