Glycyrrhizin alleviates experimental allergic asthma in mice

Ram, Arjun; Mabalirajan, Ulaganathan; Das, Moumita; Bhattacharya, Indranil; Dinda, Amit Kumar; Gangal, S. V.; Ghosh, Balaram

doi:10.1016/j.intimp.2006.04.020

Cited by 131 publications

(84 citation statements)

References 32 publications

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“…The preliminary phytochemical investigations carried out on the extracts of Z. xylopyrus has revealed the presence of carbohydrates, alkaloids, glycosides, saponins, sterols, flavonoids, phenolic compounds and tannins. The phytochemicals tests help in laying down the pharmacopoeial standards [23,24].…”

Section: Discussionmentioning

confidence: 99%

Peritoneal Mast Cell Stabilization Potential of Ziziphus Xylopyrus (Retz) Wild Extract in Rat Mesenteric Model

Gupta¹,

Raju²,

Mulukutla³

et al. 2016

Arnaldo Cantani

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Objective: To investigate the peritoneal mast cell stabilization activity of Ziziphus xylopyrus extracts. Materials and Methods:Ziziphus Xylopyrus L. (family-Rhamnaceae) stem part was successively extracted with ethanol and aqueous to prepare extract of the plant. The extracts of Ziziphus Xylopyrus (Z. xylopyrus) were evaluated for stabilization of mast cell in rat for the evaluation of Hypersensitivity type I allergic reaction in animal models. The extract of Z. xylopyrus ethanolic and aqueous (1, 10 and 100 µg/ml) was evaluated for peritoneal mast cell stabilization activity in rat mesenteric preparation induced by C 48/80. Result:Preliminary phytochemical analysis revealed the presence of carbohydrates, fixed oil, proteins, alkaloids, glycosides, flavonoids and phenolic compounds. The ethanolic and aqueous extracts of Z. xylopyrus showed dose dependent increase in the number of intact cells when compare with C 48/80 at the concentration of 10 and 100 µg/ml. It virtues further work towards the isolation of phyto constituents from this plant. Conclusion:This finding provides evidence that the Z. xylopyrus inhibits mast cell-derived immediate-type allergic reactions and mast cell degranulation. Z. xylopyrus has a potential as allergic anti-asthmatic agent.

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Section: Discussionmentioning

confidence: 99%

Peritoneal Mast Cell Stabilization Potential of Ziziphus Xylopyrus (Retz) Wild Extract in Rat Mesenteric Model

Gupta¹,

Raju²,

Mulukutla³

et al. 2016

Arnaldo Cantani

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“…In the period covered by this review, some new pharmacological activities were reported for GL (1), such as: antiviral (against flavivirus3 6 , HIV 37 and SARScoronavirus 38 ) antiallergic, 39 antithrombotic in experimental models in rats, 40,41 capable of lowering hepatocellular carcinogenesis rates in patients with interferon-resistant active chronic hepatitis C, 42 presenting a protective in vitro effect in gastric epithelial cells against H 2 O 2 -induced cell death 43 and as an inhibitor of influenza A virus uptake into human lung cells. 44 GL and GLA (2) were also reported as possessing a protective effect on acute cholestasis induced by α-naphtyl isocyanate in rats 45 and GLA was reported as an apoptosis inductor in human hepatoma, promyelotic leukemia and stomach cancer cells, 46 as an antihyperglycemic agent in rats with streptozocin-induced diabetes, 47 and as presenting antiviral activity against herpes simpex virus 1 (HSV-1).…”

Section: New Pharmacological Activities Reported For Gl and Glamentioning

confidence: 99%

Glycyrrhizin and glycyrrhetic acid: scaffolds to promising new pharmacologically active compounds

Graebin¹,

Verli²,

Guimarães³

2010

J. Braz. Chem. Soc.

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O ácido glicirrizínico (GL), também conhecido como glicirrizina, é uma saponina triterpênica, um produto natural encontrado na raiz de Glycyrrhyza glabra L. ("licquorice" ou "alcaçuz"), utilizada mundialmente como edulcorante e também na medicina tradicional do Oriente. Este artigo de revisão enfoca os novos compostos sintetizados usando GL ou sua aglicona, o ácido glicirretínico (GLA), como materiais de partida e as atividades farmacológicas descritas para os mesmos e seus derivados.Glycyrrhizinic acid (GL), also known as glycyrrhizin, is a triterpene saponin, a natural product found on the root of Glycyrrhyza glabra L. ("licquorice"), used worldwide as sweetener and in the traditional eastern medicines. This review is focused on a series of new derivatives synthesized using GL and its aglycon, glycyrrhetinic acid (GLA), as starting materials, the pharmacological activities described for those compounds, as well as new activities reported for GL and GLA themselves.

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“…A administração via oral de glicirrizina foi capaz de reverter a indução do processo asmático em camundongos, além de diminuir o infl uxo de IgE e citocinas infl amatórias derivadas de células Th2 (Ram et al, 2006). Lupeol (32), um triterpeno isolado das cascas do troco de Diplotropis ferruginea Benth.…”

Section: Saponinas E Triterpenosunclassified

Substâncias de origem vegetal potencialmente úteis na terapia da asma

Corrêa¹,

Melo²,

Costa³

2008

Rev. bras. farmacogn.

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RESUMO:A asma é uma doença infl amatória crônica, que representa um problema de saúde pública com altos números de óbitos e elevado impacto socioeconômico. A patologia é caracterizada pela fase imediata, mediada pela resposta aguda de células infl amatórias, e a tardia, que é responsável pela resposta com envolvimento de células específi cas do sistema imunológico. Atualmente, os principais tipos de fármacos utilizados no tratamento da asma são os broncodilatadores e agentes antiinfl amatórios, que aliviam os sintomas de broncoespasmo e diminuem a infl amação das vias aéreas. Entretanto, terapias com esses medicamentos não são totalmente efi cazes e provocam efeitos adversos. A escassez de fármacos seguros e o baixo acesso da população carente aos tratamentos utilizados estimulam a busca de novas substâncias potencialmente úteis no tratamento da asma. Produtos naturais de origem vegetal representam um grande potencial farmacológico contra asma, uma vez que podem fornecer moléculas diversas com mecanismos específi cos para tratamento e controle da patologia. A busca por terapias mais efi cientes e específi cas para o processo asmático mostra que a procura nos produtos naturais é promissora e possui um papel importante para a descoberta de novas terapias contra a asma.Unitermos: Asma, infl amação crônica, células Th2, plantas medicinais, produtos naturais, metabólitos secundários.ABSTRACT: "Natural products from plant origin potentially usefull in the asthma therapy". Asthma is a chronic infl ammatory disease, which represents a huge public health problem in developed and developing countries, has high death rates and elevated socioeconomic implications. The pathology is characterized by two different phases: the initial stage, mediated by acute infl ammatory cell response and the late phase, responsible for specifi c immune cells. Currently, the main drugs used for asthma treatment are bronchodilator and anti-infl ammatory agents, which mechanisms focus the relief of symptoms and attenuation of airway infl ammation. However, therapies with those drugs have side effects besides they are not totally effective. Poor accessibility in the development countries and scarcity of safety drugs lead the search for new drugs to asthma treatment. Herbal natural products have elevated pharmacological potential against asthma, once they provide several molecules with specifi c mechanisms for the pathology control and treatment. Thus, search in herbal natural products plays an important role to fi nd out specifi c and effective mechanisms.

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Glycyrrhizin alleviates experimental allergic asthma in mice

Cited by 131 publications

References 32 publications

Peritoneal Mast Cell Stabilization Potential of Ziziphus Xylopyrus (Retz) Wild Extract in Rat Mesenteric Model

Peritoneal Mast Cell Stabilization Potential of Ziziphus Xylopyrus (Retz) Wild Extract in Rat Mesenteric Model

Glycyrrhizin and glycyrrhetic acid: scaffolds to promising new pharmacologically active compounds

Substâncias de origem vegetal potencialmente úteis na terapia da asma

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