Glycyrrhizin and some analogues induce growth of primary cultured adult rat hepatocytes via epidermal growth factor receptors

Kimura, Mitsutoshi; Inoue, Hideo; Hirabayashi, Kazuhiro; Natsume, Hideshi; Ogihara, Masahiko

doi:10.1016/s0014-2999(01)01424-8

Cited by 48 publications

(32 citation statements)

References 32 publications

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“…), is known to inhibit liver injury in several animal models [1][2][3], and to induce hepatocyte proliferation [4] and liver regeneration after 70% partial hepatotectomy [5] in rats. The protective effects of GL on cocklebur hepatotoxicity have been reported in both human and rat hepatocytes [6], indicating that GL is a potent liverprotecting agent [7].…”

Section: Introductionmentioning

confidence: 99%

Hepatic protection by glycyrrhizin and inhibition of iNOS expression in concanavalin A-induced liver injury in mice

et al. 2009

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Section: Introductionmentioning

confidence: 99%

Hepatic protection by glycyrrhizin and inhibition of iNOS expression in concanavalin A-induced liver injury in mice

et al. 2009

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“…They are widely distributed in vegetables and plants such as licorice and ginkgo (Hatano et al 2000;Fukai et al 2002;Van Beek 2002). In recent years, these kinds of molecules have attracted the attention of many researchers because flavonoids display a remarkable array of biological and pharmacological activities such as antioxidant, anti-inflammatory, antimicrobial, cardiovascular protection and so on (Tamir et al 2001;Kimura et al 2001;Yokozawa and Dong 1997). Licorice derives from Glycyrrhiza uralensis Fisch, which is one of Chinese traditional medical herbs.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of superparamagnetic poly(urea-formaldehyde) adsorbents and their use for adsorption of flavonoids from Glycyrrhiza uralensis Fisch

2007

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Superparamagnetic spherical poly(urea-formaldehyde) (PUF) adsorbents were synthesized and their selective adsorption for licorice flavonoids was investigated in this paper. The magnetite (Fe 3 O 4 ) nanoparticles were prepared by co-precipitation of ferrous and ferric salts. Then the magnetic adsorbents with PUF shell were synthesized by reversed phase suspension polymerization. The spherical adsorbents have an average diameter of 50 µm and exhibit superparamagnetic characteristics. The saturation magnetization of the adsorbents was 15.1 emu/g. The sorption and desorption properties of licorice flavonoids on the adsorbents were studied. The result shows that the adsorbents have high adsorption capacity (about 16.7 mg/g (adsorbent)). The adsorption data of flavonoids generally obeys the Langmuir isotherm equation. The adsorption can reach equilibrium rapidly and depends strongly on the pH of the feed solution. The concentration of licorice flavonoids after desorption can reach 25.12% in the desorbed fraction with 75% ethanol solution, which is higher than the 21.9% of commercial macroporous resin XDA-1. HPLC showed that liquiritin, one of main flavonoids in the licorice, was retained in this fraction, while glycyrrhizic acid (GA) can be almost removed from this fraction.Abbreviations a adsorption equilibrium constant A adsorption ratio (%) C d flavonoids concentration of desorption solution (mg/ml) C e equilibrium concentration of flavonoids in the adsorption solution (mg/ml) C o initial concentration of flavonoids in the adsorption solution (mg/ml) D desorption ration (%) GA glycyrrhizic acid PUF poly(urea-formaldehyde) Q e adsorption capacity at adsorption equilibrium (mg/g adsorbents) Q m saturation adsorption capacity (mg/g adsorbents) V d volume of desorption solution (ml) V i volume of initial solution (ml) W weight of the dry adsorbents (g)

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“…Furthermore, hepatoprotective agents such as ursodeoxycholic acid, liver extracts, and a mixed solution of glycyrrhizin, glycine and L-cysteine were administered [4]. The patient continued to take predonine (2.5 mg/day) afterwards.…”

Section: Case Reportmentioning

confidence: 99%

Severe cholestatic liver failure associated with gemcitabine adjuvant monotherapy for pancreatic cancer

Okada

Egawa

Motoi

et al. 2011

Clin J Gastroenterol

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We report a case of severe hepatic failure caused by gemcitabine hydrochloride (GEM) monotherapy after pancreaticoduodenectomy for advanced pancreatic cancer. A 73-year-old woman received GEM as an adjuvant chemotherapy. She suffered from progressive edema, fatigue, and jaundice after the third GEM administration. Severe liver dysfunction and elevation of bilirubin was observed. A computed tomography scan and magnetic resonance imaging showed diffuse liver swelling suggesting severe hepatic edema with fat accumulation. Needle biopsy of the liver revealed remarkable cholestasis and fat deposition with mild damage of hepatocytes. Drug-induced liver failure was suspected. GEM-stimulated lymphocyte test was negative, but antinuclear antibody was elevated with a marked inflammatory response. She improved to an almost normal condition by steroid and liver protective therapies within a week. Although the frequency of liver failure induced by GEM monotherapy is very rare, it could be fatal. It is important to distinguish it from other causes of liver dysfunction following pancreaticoduodenectomy. Early detection and appropriate drug therapy can improve the prognosis.

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Glycyrrhizin and some analogues induce growth of primary cultured adult rat hepatocytes via epidermal growth factor receptors

Cited by 48 publications

References 32 publications

Hepatic protection by glycyrrhizin and inhibition of iNOS expression in concanavalin A-induced liver injury in mice

Hepatic protection by glycyrrhizin and inhibition of iNOS expression in concanavalin A-induced liver injury in mice

Synthesis and characterization of superparamagnetic poly(urea-formaldehyde) adsorbents and their use for adsorption of flavonoids from Glycyrrhiza uralensis Fisch

Severe cholestatic liver failure associated with gemcitabine adjuvant monotherapy for pancreatic cancer

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