2021
DOI: 10.1080/01635581.2021.1895234
|View full text |Cite
|
Sign up to set email alerts
|

Glycyrrhizin Mediates Downregulation of Notch Pathway Resulting in Initiation of Apoptosis and Disruption in the Cell Cycle Progression in Cervical Cancer Cells

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

1
37
0

Year Published

2021
2021
2025
2025

Publication Types

Select...
8

Relationship

1
7

Authors

Journals

citations
Cited by 28 publications
(38 citation statements)
references
References 48 publications
1
37
0
Order By: Relevance
“…A number of previous studies suggest the potential of triterpenes for its anticancer efficacy against several in vitro systems by instigating apoptosis ( Liang et al, 2013 ); however, studies demonstrating the mechanism behind the anticancer potential of Gly in CCa are limited. Earlier reports of our group succeeded in delineating the anticancer and antiapoptosis potential of Gly in C33A (HPV − ) CCa cells through inhibition of Notch signaling cascade ( Ahmad et al, 2021 ). Here we have subsequently investigated the antiproliferative and apoptosis inducing efficacy of Gly by studying its role on Notch pathway and HPV oncoproteins (E6 and E7).…”
Section: Discussionmentioning
confidence: 99%
“…A number of previous studies suggest the potential of triterpenes for its anticancer efficacy against several in vitro systems by instigating apoptosis ( Liang et al, 2013 ); however, studies demonstrating the mechanism behind the anticancer potential of Gly in CCa are limited. Earlier reports of our group succeeded in delineating the anticancer and antiapoptosis potential of Gly in C33A (HPV − ) CCa cells through inhibition of Notch signaling cascade ( Ahmad et al, 2021 ). Here we have subsequently investigated the antiproliferative and apoptosis inducing efficacy of Gly by studying its role on Notch pathway and HPV oncoproteins (E6 and E7).…”
Section: Discussionmentioning
confidence: 99%
“…The efficacy of FDN in instigating cell cycle arrest within A49 cells was assessed using propidium iodide (PI) stain as described previously [14]. Briefly, 5 × 10 5 A549 cells were incubated for 24 h under standard culture conditions post-FDN treatment.…”
Section: Instigation Of Cell Cycle Arrestmentioning
confidence: 99%
“…cDNA was subsequently synthesized from 2 µg of isolated RNA through a commercially procured kit. Primers used for synthesis of cDNA were described previously and are stated in Table 1 [14][15][16][17]. Afterwards, quantitative RT-PCR was performed through a commercially available qPCR kit (Thermo Scientific, Waltham, MA, USA), during which glyceraldehyde 3-phosphate dehydrogenase (GAPDH) gene was used for normalization.…”
Section: Mrna Expression (Quantitative Rt-pcr)mentioning
confidence: 99%
See 1 more Smart Citation
“…To explore AsA-induced cytotoxicity (if any) on PC-3 cells, tetrazolium-based MTT assay was undertaken as described previously [21]. PC-3 cells were seeded at a density of 5 × 10 3 cell/well in a 96-well format and allowed to adhere under optimum culture conditions as stated.…”
Section: Assessment Of Asa Mediated Toxicitymentioning
confidence: 99%