Glymphatic Dysfunction: A Bridge Between Sleep Disturbance and Mood Disorders

Yan, Tao; Qiu, Yuefeng; Yu, Xinfeng; Yang, Linglin

doi:10.3389/fpsyt.2021.658340

Cited by 37 publications

(30 citation statements)

References 153 publications

(152 reference statements)

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“…Numerous studies have shown that the glymphatic system exerts a significant effect on the distribution of a variety of substances in the brain, including not only its core waste clearance function but also the distribution and transport of nutrients such as glucose ( Lundgaard et al, 2015 ), some possible treatment substances (recombinant adeno-associated viral vectors) ( Murlidharan et al, 2016 ) and glial calcium signaling ( Rangroo Thrane et al, 2013 ). Because of its important physiological role, the glymphatic system is considered related to the occurrence and development of a variety of diseases ( Rasmussen et al, 2018 ), including neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, as well as mood disorders ( Yan et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Glymphatic System Dysfunction in Central Nervous System Diseases and Mood Disorders

Zhang

2022

Front. Aging Neurosci.

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The glymphatic system, a recently discovered macroscopic waste removal system in the brain, has many unknown aspects, especially its driving forces and relationship with sleep, and thus further explorations of the relationship between the glymphatic system and a variety of possible related diseases are urgently needed. Here, we focus on the progress in current research on the role of the glymphatic system in several common central nervous system diseases and mood disorders, discuss the structural and functional abnormalities of the glymphatic system which may occur before or during the pathophysiological progress and the possible underlying mechanisms. We emphasize the relationship between sleep and the glymphatic system under pathological conditions and summarize the common imaging techniques for the glymphatic system currently available. The perfection of the glymphatic system hypothesis and the exploration of the effects of aging and endocrine factors on the central and peripheral regulatory pathways through the glymphatic system still require exploration in the future.

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Section: Introductionmentioning

confidence: 99%

Glymphatic System Dysfunction in Central Nervous System Diseases and Mood Disorders

Zhang

2022

Front. Aging Neurosci.

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“…Lin et al found 719 shared genes between MD and insomnia, which provide insight into the genetic substrates in depression individuals' comorbid insomnia symptoms ( 7 ). Yan et al proposed that dysfunctional glymphatic pathway may serve as a bridge between sleep disturbance and depression ( 8 ). In addition, sleep disturbance has been found to play a vital role in the development of depression ( 9 ), an increase risk for depression recurrence ( 10 ), poor response to antidepressant treatment ( 11 ), and suicidal ideation ( 12 ).…”

Section: Introductionmentioning

confidence: 99%

The Function and Structure of Precuneus Is Associated With Subjective Sleep Quality in Major Depression

Zhang

2022

Front. Psychiatry

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BackgroundPoor sleep quality is related to depression. However, the investigation of the neural basis for poor sleep quality in individuals with major depression (MD) is limited.MethodsResting state functional and structural MRI data were derived from 114 MD individuals and 74 normal controls (NCs). Fractional amplitude of low-frequency fluctuation (fALFF) and gray matter volume (GMV) were used to measure function and structure of the brain. Pittsburgh Sleep Quality Index (PSQI) was performed to evaluate subjective sleep quality. Correlations were carried out to investigate links of PSQI score with brain imaging indices in MD and NCs, separately. We also examined the differences in fALFF and GMV of brain regions related to PSQI score between MD and NCs.ResultsIn contrast to NCs, MD individuals had higher PSQI score. The higher PSQI score was associated with lower fALFF and lower GMV in bilateral precuneus in MD individuals. Moreover, the MD individuals exhibited increased fALFF in bilateral precuneus compared with NCs. However, the correlation between subjective sleep quality and neuroimaging parameters was not significant in NCs.ConclusionThe implication of these findings is that the function and structure of precuneus provides a neural basis for subjective poor sleep quality in MD. Understanding this may lead to better intervention of depression and associated sleep complaints.

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“…In the acute phase of depression, brain regeneration and synaptic plasticity are compromised due to various reasons (e.g., dysregulated HPA-axis [ 43 ] and sleeping problems with reduced glymphatic brain clearance [ 44 ]). APOE ε4 allele carriers are additionally burdened by increased Aβ oligomer levels [ 7 , 8 ], which trigger depressive-like behavior as well as cognitive impairment [ 41 ] due to an influence on synaptic plasticity [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

APOE ε4 in Depression-Associated Memory Impairment—Evidence from Genetic and MicroRNA Analyses

et al. 2022

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(1) Background: The aim of this study was to replicate a reported interaction between APOE ε4 status and depression on memory function in two independent, nondemented samples from the general population and to examine the potential role of circulating plasma miRNAs. (2) Methods: The impact of the APOE ε4 allele on verbal memory and the interaction with depression is investigated in two large general-population cohorts from the Study of Health in Pomerania (SHIP, total n = 6286). Additionally, biological insights are gained by examining the potential role of circulating plasma miRNAs as potential epigenetic regulators. Analyses are performed using linear regression models adjusted for relevant biological and environmental covariates. (3) Results: Current depression as well as carrying the APOE ε4 allele were associated with impaired memory performance, with increasing effect for subjects with both risk factors. In a subcohort with available miRNA data subjects with current depressive symptoms and carrying APOE e4 revealed reduced levels of hsa-miR-107, a prominent risk marker for early Alzheimer’s Disease. (4) Conclusions: Our results confirm the effect of depressive symptoms and APOE ε4 status on memory performance. Additionally, miRNA analysis identified hsa-miR-107 as a possible biological link between APOE ε4, depressive symptoms, and cognitive impairment.

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Glymphatic Dysfunction: A Bridge Between Sleep Disturbance and Mood Disorders

Cited by 37 publications

References 153 publications

Glymphatic System Dysfunction in Central Nervous System Diseases and Mood Disorders

Glymphatic System Dysfunction in Central Nervous System Diseases and Mood Disorders

The Function and Structure of Precuneus Is Associated With Subjective Sleep Quality in Major Depression

APOE ε4 in Depression-Associated Memory Impairment—Evidence from Genetic and MicroRNA Analyses

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