The Function and Structure of Precuneus Is Associated With Subjective Sleep Quality in Major Depression

Zhang, Cun

doi:10.3389/fpsyt.2021.831524

Cited by 8 publications

(4 citation statements)

References 42 publications

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“…It has been established that abnormal functional connectivity of the precuneus is associated with sleep quality ( Kay et al, 2016 ; Xia et al, 2022 ). The findings of this study suggest that the abnormal FC of the precuneus in ID may be related to sleep deprivation, consistent with previous research findings ( Wu et al, 2021 ; Ma and Zhang, 2022 ). Therefore, the aberrant FC changes in the NAc of ID could provide better understanding of the underlying mechanisms of ID and may have implications for the treatment of insomnia disorders.…”

Section: Discussionsupporting

confidence: 92%

The nucleus accumbens functional connectivity in patients with insomnia using resting-state fMRI

Liu

Qin

et al. 2023

Front. Neurosci.

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BackgroundThe aim of this study was to investigate the functional abnormalities between the nucleus accumbens (NAc) and the whole brain in individuals with Insomnia Disorder (ID) using resting-state functional magnetic resonance imaging (fMRI). Additionally, the study aimed to explore the underlying neural mechanisms of ID.MethodsWe enrolled 18 participants with ID and 16 normal controls (NC). Resting-state functional connectivity (FC) between the NAc and the whole brain voxels was calculated and compared between the two groups to identify differential brain region. Receiver operating characteristic (ROC) curve analysis was employed to assess the ability of differential features to distinguish between groups. Furthermore, Pearson correlation analysis was performed to examine the relationship between neurocognitive scores and differential features.ResultsThe ID group exhibited significantly reduced FC values in several brain regions, including the right supplementary motor area, the bilateral middle frontal gyrus, the bilateral median cingulate and paracingulate gyri and the left precuneus. The area under the curve (AUC) of the classification model based on FC in these brain regions was 83.3%. Additionally, the abnormal functional changes observed in ID patients were positively correlated with the Fatigue Severity Scale (R = 0.650, p = 0.004).ConclusionThese findings suggest that the NAc may play a crucial role in the diagnosis of ID and could serve as a potential imaging biomarker, providing insights into the underlying neural mechanisms of the disorder.

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Section: Discussionsupporting

confidence: 92%

The nucleus accumbens functional connectivity in patients with insomnia using resting-state fMRI

Liu

Qin

et al. 2023

Front. Neurosci.

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“…Previous studies have found that spontaneous local neural activity in the precuneus decreases in people with depression 21,29 . Moreover, abnormal brain function activity in the precuneus has been associated with depression and poor sleep quality in some studies 30,31 . Based on these, we speculate that the increased temporal variability of local functional connectivity in the precuneus may be responsible for preventing depressive symptoms in CI patients.…”

Section: Discussionmentioning

confidence: 99%

Static and temporal dynamic alterations of local functional connectivity in chronic insomnia

Li,

Zeng

et al. 2024

Preprint

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Background: Several studies have revealed altered intrinsic neural activity in chronic insomnia (CI). However, the temporal variability of intrinsic neural activity in CI is rarely mentioned. This study aimed to explore static and temporal dynamic alterations of regional homogeneity (ReHo) in CI and excavate the potential associations between these changes and clinical characteristics. Methods: Eighty-seven patients with CI and seventy-eight healthy controls (HCs) were included. Resting-state functional magnetic resonance imaging was performed on all subjects and both static and dynamic ReHo were used to detect local functional connectivity. We then tested the relationship between altered brain regions, disease duration, and clinical scales. The receiver operating characteristic curve analysis was used to reveal the potential capability of these indicators to screen CI patients from HCs. Results: CI showed increased dynamic ReHo in the right precuneus and decreased static ReHo in the right cerebellum_6. The dynamic ReHo values of the right precuneus were negatively correlated with the self-rating depression score and the static ReHo values of the right cerebellum_6 were positively correlated with the Montreal Cognitive Assessment-Naming scor e. In addition, the combination of the two metrics showed a potential capacity to distinguish CI patients from HCs, which was better than a single metric alone. Conclusions: The present study has revealed the altered local functional connectivity under static and temporal dynamic conditions in patients with CI, and found the relationships between these changes, mood-related scales, and cognitive-related scales. These may be useful in elucidating the neurological mechanisms of CI and accompanying symptoms.

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“…Our study showed lower ReHo values in the precuneus and posterior cingulate gyrus in CRSwOD than in HC, and there was a negative relationship between ReHo values and QOD-NS in these two regions in Pearson correlation analysis in CRSwOD. This suggests that reduced olfactory input may lead to disturbances in regional brain activity in the precuneus and posterior cingulate gyrus, which are associated with low quality of life and depression ( Ma and Zhang, 2021 ; Zhu et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Regional homogeneity alterations of resting-state functional magnetic resonance imaging of chronic rhinosinusitis with olfactory dysfunction

Zhang

Luo

et al. 2023

Front. Neurosci.

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ObjectivesThe aim of this study was to assess the brain functional changes of patients with chronic rhinosinusitis with olfactory dysfunction (CRSwOD) using regional homogeneity (ReHo) of resting-state functional magnetic resonance imaging (MRI) scans, and to better explain the occurrence and development of olfactory decline in patients with chronic sinusitis provides a new idea for the study of more advanced olfactory therapy modalities.MethodsA total of 28 CRSwOD patients, 24 patients with CRS without olfactory dysfunction (CRSsOD), and 25 healthy controls (HCs) were recruited. All subjects underwent olfactory testing, clinical and brief psychological assessments, and MRI scans. A two-sided two-sample t test with AlphaSim correction (voxel-p < 0.001, cluster size >54 voxels) was used to detect differences between CRSwOD, CRSsOD, and HC groups.ResultsCompared with HCs, the ReHo values in traditional olfactory regions (e.g., parahippocampal gyrus (PHG), hippocampal, olfactory cortex) were increased, and ReHo values in the frontal gyrus, middle temporal gyrus, precuneus, and posterior cingulate gyrus were decreased in CRSwOD patients. The ReHo values in the precuneus and posterior cingulate gyrus of CRSwOD patients were negatively correlated with Questionnaire of Olfactory Disorders-Negative Statements (QOD-NS) scores. Compared with CRSsOD patients, the ReHo values in cerebellar regions were increased and those in the inferior temporal gyrus, precuneus, postcentral, and paracentral gyrus were decreased in CRSwOD patients. The receiver operating characteristic (ROC) curve showed that the mean ReHo values significantly differed between the CRSwOD and CRSsOD groups.ConclusionSynchronization of regional brain activity in the regions of the secondary olfactory cortex orbitofrontal cortex (OFC), temporal gyrus, precuneus, and cerebellum may be closely related to the development of olfactory dysfunction. Precuneus and posterior cingulate gyrus may be critical brain areas of action for emotional dysfunction in CRSwOD patients.

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The Function and Structure of Precuneus Is Associated With Subjective Sleep Quality in Major Depression

Cited by 8 publications

References 42 publications

The nucleus accumbens functional connectivity in patients with insomnia using resting-state fMRI

The nucleus accumbens functional connectivity in patients with insomnia using resting-state fMRI

Static and temporal dynamic alterations of local functional connectivity in chronic insomnia

Regional homogeneity alterations of resting-state functional magnetic resonance imaging of chronic rhinosinusitis with olfactory dysfunction

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