Glyprolines and Semax Prevent Stress-Induced Microcirculatory Disturbances in the Mesentery

Abstract

One-hour immobilization stress considerably disturbed microcirculation in the mesentery: blood flow in small mesenteric vessels decreased or stopped and numerous hemorrhages appeared. Lymphatic vessels lost spontaneous activity and did not respond to norepinephrine. Administration of Semax and glyprolines 1 h before stress decreased the severity of stress-induced microcirculatory disturbances. PGP and GP were most effective in this respect.

The role of protective effects of proline-containing peptides (PGP, PG, and GP) in contractile dysfunction of mesenteric lymphatic vessels in rats with experimental acute peritonitis

“…Vital microscopy of mesenteric microcirculatory bed was performed at various stages of peritonitis (30 min and 2, 6, and 18 h after administration of thioglycollate) [3].…”

“…Pretreatment with proline-containing peptides (PGP, PG, and GP) prevents the development of stress-induced microcirculatory disturbances [3,4].…”

Peptide correction of disorders in rat mesenteric microcirculatory system during inflammation

“…The function of these cells is characterized by a drastic increase in the level of secretory activity. We previously showed that injection of glyprolines before stress exposure significantly attenuated the stressogenic disorders in the rat mesenteric microcirculation [2]. Stabilization of mast cells by preinjection of ketotifene prevented stressinduced disorders in contractile activity of mesenteric lymph vessels and reduced stressogenic activation of mast cells [1].…”

“…We previously showed that injection of glyprolines before stress exposure significantly attenuated the stressogenic disorders in the rat mesenteric microcirculation [2]. Stabilization of mast cells by preinjection of ketotifene prevented stressinduced disorders in contractile activity of mesenteric lymph vessels and reduced stressogenic activation of mast cells [1]. Increased secretory activity of mast cells during inflammation suggested that the protective effect of PGP is mediated by inhibition of secretory activity of mast cells during inflammation-induced disorders of contractile activity of lymph vessels.…”

“…The mesenteric microcirculatory system was studied by vital microscopy 2 h after injection of thioglycolate by the method described previously [2].…”