Gm Allotypes in Multiple Sclerosis

Bulman, Dennis E.; Pandey, Janardan P.; Ebers, G. C.

doi:10.1007/978-1-4899-5348-3_10

Cited by 5 publications

(2 citation statements)

References 11 publications

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“…Our study, using seven CH region polymorphisms and eight VH polymorphisms, found no association between the CH region and MS patients, consistent with the earlier report in the Canadian MS population of no association with the Gm allotypes (60). The recent identification ofa hot spot for recombination between the CA and Cy3 genes (27,34) suggests that association between MS and the VH region could not be identified using IgG polymorphisms alone.…”

Section: Resultssupporting

confidence: 90%

“…Several studies reported an elevation of the IgG marker Gm"'7;21 haplotype in MS patients (57)(58)(59). However, Bulman et al (60) found no association and Haile et al (61) found no linkage between Gm markers and MS. Gaiser et al (28) reported an association between a DNA polymorphism of IgG3 and MS, but found no association between IgG1 and MS. Furthermore, the IgG3 association was with the opposite allele of IgG3 reported elevated in MS patients in the previous studies (57)(58)(59).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Susceptibility to multiple sclerosis is associated with the proximal immunoglobulin heavy chain variable region.

Walter¹,

Gibson²,

Ebers³

et al. 1991

J. Clin. Invest.

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15 immunoglobulin heavy chain constant (CH) and variable region (VH) polymorphisms were selected to span the entire length of the heavy chain cluster. These polymorphisms were examined in 34 sib pairs concordant for multiple sclerosis (MS) and in 23 sporadic MS patients. Allele frequencies were calculated for the 2 MS patient groups and compared with those found in a control population from the same geographical location and of similar ethnic background. No significant association was found between MS and the 7 CH region polymorphisms examined. However, a significant correlation between the MS phenotype and a VH2 family polymorphism was observed in both MS patient populations (familial MS patients x2 = 8.16, P < 0.005; sporadic MS patients x2 = 8.90, P < 0.005). One allele of the VH2-5 gene segment was found to be overrepresented in both MS groups. VH2-5 has recently been physically mapped close to the CH region, between 180 and 360 kb away. These results indicate that a locus near or within the CH-proximal VH region is associated with increased susceptibility to MS. (J. Clin.

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Section: Resultssupporting

confidence: 90%