Gmelinosides A−L, Twelve Acylated Iridoid Glycosides from Gmelina arborea

Hosny, Mohammed; Rosazza, John P. N.

doi:10.1021/np970447u

Cited by 45 publications

(26 citation statements)

References 28 publications

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“…Hentriacontanol[6] and lignans such as arboreol, isoarboreol, methyl arboreol, arborone, gmelanone, gummadiol, and 7-oxodihydrogmelinol[789] have been isolated from heartwood of the plant. Few coumarin glycosides[10] and iridoid glycosides[11] have been reported in roots and leaves, respectively. Three iridoid glycosides 6-O-(3“- O -benzoyl)-α-L-rhamnopyranosylcatalpol, 6- O -(3“- O -trans-cinnamoyl)-α-L-rhamnopyranosylcatalpol and 6- O -(3“- O -cis-cinnamoyl)-α-L-rhamnopyranosylcatalpol were isolated from aerial parts of G. arborea and structures were elucidated by spectral analysis.…”

Section: Introductionmentioning

confidence: 99%

Effect of Gmelina arborea Roxb in experimentally induced inflammation and nociception

Kulkarni

Panjabi

Patel

et al. 2013

J Ayurveda Integr Med

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Background:Gmelina arborea Roxb (Verbenaceae), also known as “Gambhari”, is an important medicinal plant in the Ayurveda. There are no meticulous scientific reports on effect of the plant on inflammation and pain.Objective:To study the anti-inflammatory and anti-nociceptive properties of aqueous extracts (AE) and methanol extracts (ME) of G. arborea.Materials and Methods:The AE and ME of stembark of G. arborea was prepared by cold maceration and Soxhlet extraction technique respectively. Anti-inflammatory activity was determined in Wistar albino rats in a model of acute plantar inflammation induced by carrageenan. The anti-nociceptive activity was evaluated by using hot plate test and writhing test in Swiss albino mice. Significant differences between the experimental groups were assessed by analysis of variance.Results:AE and ME at dose of 500 mg/kg showed maximum inhibition in carrageenan induced inflammation up to 30.15 and 31.21% respectively. In hot plate test, the AE and ME showed the maximum response of 8.8 ± 0.97 (P < 0.01) and 8.2 ± 1.24 (P < 0.01) respectively at dose of 500 mg/kg when compared with control. AE showed maximum inhibition of writhing response (84.3%) as compared to ME (77.9%) in writhing test at a dose of 500 mg/kg.Conclusion:The findings suggested that G. arborea possess significant anti-inflammatory and anti-nociceptive activities.

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Section: Introductionmentioning

confidence: 99%

Effect of Gmelina arborea Roxb in experimentally induced inflammation and nociception

Kulkarni

Panjabi

Patel

et al. 2013

J Ayurveda Integr Med

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“…Lignans such as arboreol, isoarboreol, methyl arboreol, arborone, gmelanone, gummadiol, and 7-oxodihydrogmelinol [4][5][6] have been isolated from heartwood of the plant. Few coumarin glycosides [7] and iridoid glycosides [8] have been reported in roots and leaves, respectively. Three iridoid glycosides 6-O-(3-O-benzoyl)--l-rhamnopyranosylcatalpol, 6-O-(3-O-transcinnamoyl)--l-rhamnopyranosylcatalpol a n d 6 -O -( 3  -O -c i s -c i n n a m o y l ) - -lrhamnopyranosylcatalpol were isolated from aerial parts of G. arborea and structures were elucidated by spectral analysis.…”

Section: Introductionmentioning

confidence: 99%

Toxicity study and analgesic activity of Gmelina arborea extract and its fractions

Kulkarni¹,

Shah²,

Chavan³

2013

J Nat Pharm

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Gmelina arborea is an important medicinal plant in the traditional system of medicine in India. The present study was designed to evaluate toxicity and analgesic activity of the alcoholic extract (AlcE) of G. arborea stem bark and its various fractions. The AlcE was prepared by the Soxhlet extraction technique. AlcE was fractionated with petroleum ether, chloroform, ethyl acetate, and n-butanol. The acute toxicity of AlcE and its fractions was studied in female Swiss albino mice using the OECD guidelines. In the acute toxicity test, mice were treated with AlcE and its fractions (2000 mg/kg), orally. Animals were observed periodically during the fi rst 24 h after administration and daily thereafter for 14 days. The analgesic activity was studied in Swiss albino mice by using acetic acid-induced writhing method. The AlcE (250 and 500 mg/kg) and its fractions (200 mg/kg) were administered to animals before 45 minutes of administration of acetic acid. The number of muscular contractions was counted over a period of 10 minutes after acetic acid injection. AlcE and its fractions did not produce mortality, changes in behavior or any other physiological activities in mice, at selected dose. The AlcE at 250 and 500 mg/kg showed a signifi cant decrease in writhes -13.4 ± 0.16 and 12.2 ± 0.22, respectively when compared with control (19.2 ± 0.58). The n-butanol fraction showed maximum inhibition of writhes (57.37%) as compared to other fractions. These fi ndings suggested that AlcE and its fractions are safe after oral administration and have signifi cant analgesic activity.

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“…On the other hand, the presence of an O-glycosidic bond at C-3 of kaempferol was confi rmed by the correlation signal between C-3 and H-1'' at δ C 133.6 ppm/δ H 5.56 ppm. In the 1 H NMR spectrum of 4, trans-confi guration of the cinnamic acid moieties was evidenced by four proton signals at δ H 6.40 (H-8'''), 6.67 (H-8 IV ), 7.40 (H-7'''), and 7.70 ppm (H-7 IV ) with a coupling constant of J = 16.0 Hz (Markham, 1982;Markham and Geiger, 1994;Abdel-Shafeek et al, 2000;Hosny and Rosazza, 1998). The values of the chemical shifts of the proton pairs H-8''',H-7''' and H-8 IV ,H-7 IV were assigned on the basis of the correlation displayed in COSY and HSQC spectra.…”

Section: Resultsmentioning

confidence: 99%

Flavonoids from Pseudotsuga menziesii

Krauze-Baranowska

Sowiński

Kawiak

et al. 2013

Zeitschrift Für Naturforschung C

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1 Four O-acylated flavonol glycosides, new in the plant kingdom, were isolated from the needles of Pseudotsuga menziesii. Their structures were established by 1D and 2D NMR and MS data as: daglesioside I [kaempferol 3-O-[2’’,5’’-O-(4’’’,4IV-dihydroxy)-β- truxinoyl]-α-L-arabinofuranoside] (), daglesioside II [kaempferol 3-O-[2’’,5’’-O-(4’’’- hydroxy)-β-truxinoyl]-α-L-arabinofuranoside] (2), daglesioside III [kaempferol 3-O-[2’’,5’’- di-O-(E)-p-coumaroyl]-α-L-arabinofuranoside] (3), and daglesioside IV [kaempferol 3-O-[3’’,6’’-di-O-(E)-cinnamoyl]-β-D-glucopyranoside] (4). In addition, the known fl avonoids (E)-tiliroside, (E)-ditiliroside, astragalin (kaempferol 3-O-β-D-glucopyranoside), isorhamnetin, kaempferol, and quercetin were identifi ed. The cytotoxic activity of compounds 1 and 3 was evaluated towards the HL-60, HeLa, and MDA-MB468 cell lines.

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Gmelinosides A−L, Twelve Acylated Iridoid Glycosides from Gmelina arborea

Cited by 45 publications

References 28 publications

Effect of Gmelina arborea Roxb in experimentally induced inflammation and nociception

Effect of Gmelina arborea Roxb in experimentally induced inflammation and nociception

Toxicity study and analgesic activity of Gmelina arborea extract and its fractions

Flavonoids from Pseudotsuga menziesii

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