Floods are severe natural disasters that are harmful and frequently occur across the world. From May to July 2022, the strongest, broadest, and longest rainfall event in recent years occurred in Guangdong Province, China. The flooding caused by continuous precipitation and a typhoon resulted in severe losses to local people and property. During flood events, there is an urgent need for timely and detailed flood inundation mapping for areas that have been severely affected. However, current satellite missions cannot provide sufficient information at a high enough spatio-temporal resolution for flooding applications. In contrast, spaceborne Global Navigation Satellite System reflectometry technology can be used to observe the Earth’s surface at a high spatio-temporal resolution without being affected by clouds or surface vegetation, providing a feasible scheme for flood disaster research. In this study, Cyclone Global Navigation Satellite System (CYGNSS) L1 science data were processed to obtain the change in the delay-Doppler map and surface reflectivity (SR) during the flood event. Then, a flood inundation map of the extreme precipitation was drawn using the threshold method based on the CYGNSS SR. Additionally, the flooded areas that were calculated based on the soil moisture from the Soil Moisture Active Passive (SMAP) data were used as a reference. Furthermore, the daily Dry Wet Abrupt Alternation Index (DWAAI) was used to identify the occurrence of the flood events. The results showed good agreement between the flood inundation that was derived from the CYGNSS SR and SMAP soil moisture. Moreover, compared with the SMAP results, the CYGNSS SR can provide the daily flood inundation with higher accuracy due to its high spatio-temporal resolution. Furthermore, the DWAAI can identify the transformation from droughts to floods in a relatively short period. Consequently, the distributions of and variations in flood inundation under extreme weather conditions can be identified on a daily scale with good accuracy using the CYGNSS data.