Goat Milk Oligosaccharides Are Anti-Inflammatory in Rats with Hapten-Induced Colitis

Abstract

Oligosaccharides are included among the anti-inflammatory components of milk because of their prebiotic properties and their capacity to act as receptors of microorganisms. Here the intestinal anti-inflammatory effect of goat milk oligosaccharides (O) was assessed in trinitrobenzenesulfonic (T) acid-induced colitis in rats. Rats were randomly assigned to three different groups. Two groups (T and OS) of colitic rats and a control group (C) were studied. Group OS received 500 mg/(kg.d) of goat milk oligosaccharides orally, starting 2 d before the colitis induction until d 6, and groups T and C received the vehicle. When compared with the T group, the OS group showed decreased anorexia and body weight loss; reduced bowel wall thickening and longitudinal extension of necrotic lesions; downregulated colonic expression of interleukin 1beta, inducible nitric oxide synthase, cyclooxygenase 2, and mucin 3; and increased trefoil factor 3. Thus, goat milk oligosaccharides have anti-inflammatory effects in rats with experimental colitis and may be useful in the management of inflammatory bowel disease.

The Role of Intestinal Barrier Function in Early Life in the Development of Colitis

“…For example, glycomacropeptide derived from kappa casein, has anti-inflammatory activity in a rat model of colitis, suggesting potential for IBD treatment (Daddaoua et al, 2005). Oligosaccharides from goat milk have been shown to enhance recovery from colonic inflammatory damage in a rat model of colitis and may therefore also be useful for treatment of IBD (Daddaoua et al, 2006).…”

Prebiotics in Chronic Intestinal Inflammation

“…Active hexosecorrelated compound, a product prepared from the mycelium of edible Basidiomycete fungi and which contains oligosaccharides, also showed disease reduction in TNBS-induced colitis. 80,81 In contrast, treatment with galacto-oligosaccharides (GOS) had no effect, despite an increase of intestinal bifidobacteria, 82 indicating that an increase of these bacteria is not always associated with protection. …”

Ameliorating Effects of Short-Chain Inulin-Like Fructans on the Healing Stage of Trinitrobenzene Sulfonic Acid-Induced Colitis in Rats

“…We therefore assumed that these anti-inflammatory effects of SIF might be exerted through a shield-like effect against endotoxin and bacterial translocation at the early stage of colitis, leading to the reduced colonic damage 10 d after the induction of colitis. 7) A number of studies examining the effects of prebiotics, including dietary fiber and probiotics, on TNBSinduced rat colitis have already been reported, but most of them evaluated the preventive effects in the acute phase of colitis within 1-2 weeks after TNBS administration; 5,6,[9][10][11][12] the outcome was mostly successful when the treatment began before the induction of colitis. Indeed, Peran et al 6) have reported for rats that a pretreatment of Lactobacillus rutei and L. fermentum, starting 2 weeks before TNBS administration, significantly reduced colonic damage both histologically and biochemically.…”