This paper describes the introduction of a virtual microscope (VM) that has allowed preclinical histology teaching to be fashioned to better suit the needs of approximately 900 undergraduate students per year studying medicine, dentistry or veterinary science at the University of Bristol, UK. Features of the VM implementation include: 1) the facility for students and teachers to make annotations on the digital slides; 2) in-house development of VM-based quizzes that are used for both formative and summative assessments; 3) archiving of teaching materials generated each year, enabling students to access their personalized learning resources throughout their programs; 4) retention of light microscopy capability alongside the VM. Student feedback on the VM is particularly positive about its ease of use, the value of the annotation tool, the quizzes and the accessibility of all components off-campus. Analysis of login data indicates considerable, although variable, use of the VM by students outside timetabled teaching.The median number of annual logins per student account for every course exceeded the number of timetabled histology classes for that course (1.6 -3.5 times). The total number of annual student logins across all cohorts increased from approximately 9,000 in 2007-08 to 22,000 in 2010-11. The implementation of the VM has improved teaching and learning in practical classes within the histology laboratory and facilitated consolidation and revision of material outside the laboratory. Discussion is provided of some novel strategies that capitalize on the benefits of introducing a VM, as well as strategies adopted to overcome some potential challenges.3