Gold-Embedded Hollow Silica Nanogolf Balls for Imaging and Photothermal Therapy

Janetanakit, Woraphong; Wang, Liping; Santacruz-Gómez, Karla; Landon, Preston B.; Sud, Paul L.; Patel, N. K.; Jang, Grace; Jain, Malvika; Yepremyan, Alice; Kazmi, Sami; Ban, Deependra Kumar; Zhang, Feng; Lal, Ratnesh

doi:10.1021/acsami.7b08398

Cited by 12 publications

(3 citation statements)

References 39 publications

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“…The Lan-PdNPs@GSH/DOX demonstrated a rapid rise in temperature under NIR irradiation. The local hyperthermia not only ablated tumor cells directly but also cooperatively enhanced cell uptake of nanocarriers, promoted DOX release, increased intracellular drug concentration, therefore improved the therapeutic effect of DOX . Because of the synergistic effect of chemotherapy and PTT, the cell viability in the Lan-PdNPs@GSH/DOX plus laser group was far below that in any single therapy (free DOX or PTT).…”

Section: Resultsmentioning

confidence: 86%

Dual Stimuli-Responsive Peptide-Based Palladium Nano-Lychee Spheres for Synergistic Antitumor Therapy

Zhang

Yin

Wang

et al. 2019

ACS Biomater. Sci. Eng.

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The application of peptide-based biomaterials in nanocarriers can effectively reduce toxicity and improve the biocompatibility. In our study, a dual stimuli-responsive peptide-based drug delivery system was designed and synthesized, which was nontoxic and achieved the chemphotothermal therapy synergistic effect. Lanreotide (Lan), a kind of somatostatin analogue, was used as internal template to prepared lychee-shaped palladium (Pd) nanoparticles (Lan-PdNPs). Glutathione (GSH) and doxorubicin (DOX) were combined on the surface of Lan-PdNPs to obtain the nanosystem of Lan-PdNPs@GSH/DOX. Based on the lychee-shaped structures, the system demonstrated higher photothermal conversion performance and photothermal stability. Under NIR laser irradiation, Lan-PdNPs@GSH/ DOX could convert light energy to heat in effect and accelerate drug release. Moreover, in acidic conditions, the system also exhibited the pH-responsive drug release. Owing to the synergism, the antitumor effects of Lan-PdNPs@GSH/DOX in vitro and in vivo were superior, and the inhibition ratio was much higher than that of chemotherapy or photothermal therapy alone. The good biocompatibility and nontoxicity of the system also provide the possibility for serving as an antitumor drug candidate.

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Section: Resultsmentioning

confidence: 86%

Dual Stimuli-Responsive Peptide-Based Palladium Nano-Lychee Spheres for Synergistic Antitumor Therapy

Zhang

Yin

Wang

et al. 2019

ACS Biomater. Sci. Eng.

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“…Anisotropic gold nanoparticles are more likely to exhibit LSP in the near-infrared radiation (NIR), which make them particularly interesting for bio applications such as SERS-based biosensing, imaging, and cancer therapy [22]. These capabilities extend to scenarios where gold nanoparticles are seamlessly integrated into nanocomposites, further broadening their potential application as needed [23,24].…”

Section: The Quantum Effect Of Gold Nanoparticles: Localized Surface ...mentioning

confidence: 99%

Optimizing Surface-Enhanced Raman Spectroscopy Substrates with Gold Nanospheres, Nanorods and Nanostars

Santacruz-Gomez,

López Durazo,

Gutiérrez Félix

et al. 2023

Epistemus

Self Cite

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Surface-Enhanced Raman Spectroscopy is a powerful technique that boosts the distinctive fingerprint signals of molecules, making them more accessible for analysis. It utilizes metallic nanoparticles, acting as amplifiers, to greatly enhance the signals emitted by the molecules. This study aimed to explore the SERS potential of gold nanoparticles (AuNPs) with different geometries using a non-resonant molecule, 4-MBA. Nanospheres (14±2 nm), nanorods (11±2 nm x 50±7 nm) and nanostars (38±4 nm) were synthesized via the HAuCl4 reduction method. All three AuNP geometries exhibited a remarkable enhancement of the Raman signal of 4-MBA by a magnitude of 104. Notably, only gold nanorods and nanostars displayed localized surface plasmon within the biological window, making them highly suitable for biological sample analysis. Meanwhile, the application of gold nanospheres should be limited to chemical SERS detection. These findings confirm the potential use of these nanostructures as SERS substrates for studying molecules with low molar...

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“…In addition to HMONs, some metal hollow nanostructures with strong NIR absorption show high photothermal conversion efficiency and excellent photoacoustic imaging (PA) ability due to the local plasmon resonance effect [91][92][93][94][95][96]. In 2019, Liang and co-workers synthesized a temperature-sensitive polymer modified Pt-CuS hollow structure [97].…”

Section: Inorganic Nanomaterials As the Nano Carriers Of Molecular Somentioning

confidence: 99%

Recent advances in nanomaterials for sonodynamic therapy

et al. 2020

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Sonodynamic therapy (SDT), as a novel non-invasive strategy for eliminating tumor, has the advantages of deeper tissue penetration, fewer side effects, and better patient compliance, compared with photodynamic therapy (PDT). In SDT, ultrasound was used to activate sonosensitizer to produce cytotoxic reactive oxygen species (ROS), induce the collapse of vacuoles in solution, and bring about irreversible damage to cancer cells. In recent years, much effort has been devoted to developing highly efficient sonosensitizers which can efficiently generate ROS. However, the traditional organic sonosensitizers, such as porphyrins, hypericin, and curcumins, suffer from complex synthesis, poor water solubility, and low tumor targeting efficacy which limit the benefits of SDT. In contrast, inorganic sonosensitizers show good in vivo stability, controllable physicochemical properties, ease of achieving multifunctionality, and high tumor targeting, which greatly expanded their application in SDT. In this review, we systematically summarize the nanomaterials which act as the carrier of molecular sonosensitizers, and directly produce ROS under ultrasound. Moreover, the prospects of inorganic nanomaterials for SDT application are also discussed.

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Gold-Embedded Hollow Silica Nanogolf Balls for Imaging and Photothermal Therapy

Cited by 12 publications

References 39 publications

Dual Stimuli-Responsive Peptide-Based Palladium Nano-Lychee Spheres for Synergistic Antitumor Therapy

Dual Stimuli-Responsive Peptide-Based Palladium Nano-Lychee Spheres for Synergistic Antitumor Therapy

Optimizing Surface-Enhanced Raman Spectroscopy Substrates with Gold Nanospheres, Nanorods and Nanostars

Recent advances in nanomaterials for sonodynamic therapy

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