Gold(I)–NHC complexes of antitumoral diarylimidazoles: Structures, cellular uptake routes and anticancer activities

Novel symmetrically p-benzyl-substituted 4,5-diaryl-imidazole N-heterocyclic carbene-silver(I) acetate complexes – Synthesis and biological evaluation

“…As previously reported by us, novel benzyl-substituted Nheterocyclic carbene-silver [11e17] and carbeneegold complexes [18,19] exhibited good activity against the cancer cell line Caki-1 (renal) and antibacterial activity against the strains Escherichia coli and Staphylococcus aureus.…”

N -heterocyclic carbenes (NHC) with 1,2,4-oxadiazole-substituents related to natural products: Synthesis, structure and potential antitumor activity of some corresponding gold(I) and silver(I) complexes

“…These results are much better than results from previous work presented in this area [71]. So has the pyridine based NHC-Au(I) complex 18 with an IC 50 of 0.012 by a factor of at least 800 a better activity than the former results.…”

Adjusting the DNA Interaction and Anticancer Activity of Pt(II) N-Heterocyclic Carbene Complexes by Steric Shielding of the Trans Leaving Group

“…In recent years, antitumoral complexes of other transition metals including gold, silver, palladium, copper, rhodium, and ruthenium, bearing Nheterocyclic carbene (NHC) ligands have come to the fore. [7][8][9][10][11] This is in part owed to phosphane)platinum(II). The benzylic protons gave rise to a singlet in the 1 H NMR spectrum of 3c which proves that the two phosphane ligands stand trans to each other.…”