Gold(III) Tetraarylporphyrin Phosphonate Derivatives as Potential Anticancer Agents

Chen, Huasheng; Li, Jun; Shen, Tingting; Li, Yan; Liu, Juanjuan; Liu, Jinliang; Xu, Anjian; Wang, Cunde

doi:10.3184/174751912x13406179445757

Cited by 4 publications

(4 citation statements)

References 31 publications

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“…For example, Chen et al synthesized gold(III) tetraarylporphyrin phosphonate derivatives. 17 Kojima et al synthesized gold complexes bearing phosphoric acids used in asymmetric catalysis. 18 Gardea-Torresdey and Yin et al found that the carboxyl group/ phosphonic acid group plays some role in the binding of Au(III) and higher gold(III) binding at low pHs.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…Oxygen is a hard base while gold is a soft acid according to HSAB; therefore, only a few studies on the interaction between these two elements have been reported. For example, Chen et al synthesized gold(III) tetraarylporphyrin phosphonate derivatives . Kojima et al synthesized gold complexes bearing phosphoric acids used in asymmetric catalysis .…”

Section: Resultsmentioning

confidence: 99%

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Biosorption of Heavy Metal Ions onto Agricultural Residues Buckwheat Hulls Functionalized with 1-Hydroxylethylidenediphosphonic Acid

Yin

Wang

et al. 2012

J. Agric. Food Chem.

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Novel biosorbent materials obtained from agricultural residues buckwheat hulls (BH) were successfully developed through functionalization with 1-hydroxylethylidenediphosphonic acid (HEDP), and they were characterized. This paper reports the feasibility of using HEDP-BH for removal of heavy metals from stimulated wastewater, the experimental results revealed that the adsorption property of functionalized buckwheat hulls with 120 mesh 120-HEDP-BH for Au(III) was very excellent, and the monolayer maximum adsorption capacity for Au(III) calculated from the Langmuir isotherm models was up to 450.45 mg/g at 35 °C. The combined effect of initial solution pH, 120-HEDP-BH dosage, and initial Au(III) concentration was investigated using response surface methodology (RSM), and the result showed that biomass dosage exerted a stronger influence on Au(III) uptake than those of initial pH and initial Au(III) concentration. Analysis of variance (ANOVA) of the quadratic model demonstrated that the model was highly significant. Moreover, investigation on the adsorption selectivity showed that 120-HEDP-BH displayed strong affinity for gold in aqueous solutions and even exhibited 100% selectivity for Au(III) ions in the presence of Zn(II) and Co(II). Regeneration capacities of 120-HEDP-BH were studied using the eluent solutions of 0.0-5.0% thiourea in 0.1 mmol/L HCl, and it was found that the adsorption capability remains high after several cycles of adsorption-desorption process.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Biosorption of Heavy Metal Ions onto Agricultural Residues Buckwheat Hulls Functionalized with 1-Hydroxylethylidenediphosphonic Acid

Yin

Wang

et al. 2012

J. Agric. Food Chem.

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“…Among the metal-based compounds used for medical applications, porphyrin gold(III) complexes are receiving increasing attention as chemotherapies rather than PDT drugs because of their promising in vitro and in vivo anticancer activities [ 99 , 100 , 101 , 102 ]. It has been shown that porphyrin is one of the best-stabilizing ligands of gold(III) for avoiding its reduction, and porphyrin substitutions increase its complex solubility and cytotoxicity [ 103 , 104 , 105 ]. Activation of mitochondrial dysfunction and other apoptotic cellular events, and interaction with some specific enzymatic targets, such as selenol or thiol-containing thioredoxin reductase, proteasome, glutathione reductase, and peroxidase, have been proposed to account for the anticancer activities of gold complexes [ 106 ].…”

Section: Gold Porphyrins For the Treatment Of Colorectal Cancermentioning

confidence: 99%

Porphyrin/Chlorin Derivatives as Promising Molecules for Therapy of Colorectal Cancer

et al. 2021

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Colorectal cancer (CRC) is a leading cause of cancer-related death. The demand for new therapeutic approaches has increased attention paid toward therapies with high targeting efficiency, improved selectivity and few side effects. Porphyrins are powerful molecules with exceptional properties and multifunctional uses, and their special affinity to cancer cells makes them the ligands par excellence for anticancer drugs. Porphyrin derivatives are used as the most important photosensitizers (PSs) for photodynamic therapy (PDT), which is a promising approach for anticancer treatment. Nevertheless, the lack of solubility and selectivity of the large majority of these macrocycles led to the development of different photosensitizer complexes. In addition, targeting agents or nanoparticles were used to increase the efficiency of these macrocycles for PDT applications. On the other hand, gold tetrapyrrolic macrocycles alone showed very interesting chemotherapeutic activity without PDT. In this review, we discuss the most important porphyrin derivatives, alone or associated with other drugs, which have been found effective against CRC, as we describe their modifications and developments through substitutions and delivery systems.

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“…human hepatic cancer cells (IC 50 ¼ 2.60 mM). Regretfully, none of these compounds exhibited more excellent anticancer activity than gold(III) tetraphenyl-porphyrin 117,118 .…”

Section: Metal-modified Porphyrin Derivativesmentioning

confidence: 99%

Chemical approaches for the enhancement of porphyrin skeleton-based photodynamic therapy

Lin

Zhou

Bai

et al. 2020

Journal of Enzyme Inhibition and Medicinal Chemistry

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With the development of photodynamic therapy (PDT), remarkable studies have been conducted to generate photosensitisers (PSs), especially porphyrin PSs. A variety of chemical modifications of the porphyrin skeleton have been introduced to improve cellular delivery, stability, and selectivity for cancerous tissues. This review aims to highlight the developments in porphyrin-based structural modifications, with a specific emphasis on the role of PDT in anticancer treatment and the design of PSs to achieve a synergistic effect on multiple targets.

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Gold(III) Tetraarylporphyrin Phosphonate Derivatives as Potential Anticancer Agents

Cited by 4 publications

References 31 publications

Biosorption of Heavy Metal Ions onto Agricultural Residues Buckwheat Hulls Functionalized with 1-Hydroxylethylidenediphosphonic Acid

Biosorption of Heavy Metal Ions onto Agricultural Residues Buckwheat Hulls Functionalized with 1-Hydroxylethylidenediphosphonic Acid

Porphyrin/Chlorin Derivatives as Promising Molecules for Therapy of Colorectal Cancer

Chemical approaches for the enhancement of porphyrin skeleton-based photodynamic therapy

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