With the development of photodynamic therapy (PDT), remarkable studies have been conducted to generate photosensitisers (PSs), especially porphyrin PSs. A variety of chemical modifications of the porphyrin skeleton have been introduced to improve cellular delivery, stability, and selectivity for cancerous tissues. This review aims to highlight the developments in porphyrin-based structural modifications, with a specific emphasis on the role of PDT in anticancer treatment and the design of PSs to achieve a synergistic effect on multiple targets.

An Fe(NO3)3·9H2O‐catalyzed cross‐dehydrogenative coupling reaction between N‐hydroxyphthalimide (NHPI) or N‐hydroxysuccinimide (NHSI) and aldehydes or alcohols in air is described. This transformation represents an efficient approach to the preparation of N‐hydroxyimide ester derivatives in moderate to excellent yields, and has a wide substrate scope.

A pseudo-rigid fluorophore with multiple conformers enables highly reliable single-fluorophore ratiometric temperature sensing.

Key indicatorsSingle-crystal X-ray study T = 294 K Mean (C-C) = 0.004 Å R factor = 0.040 wR factor = 0.105 Data-to-parameter ratio = 16.6For details of how these key indicators were automatically derived from the article, see

A copper nitrate-catalyzed cross-dehydrogenative coupling reaction between N-hydroxyphthalimide (NHPI) and ethers/alkanes has been described. The reaction is accomplished smoothly by using simple and green molecular oxygen as the oxidant, providing an alternative for the efficient synthesis of N-alkoxyphthalimides. In addition, it was found that when tert-butyl ethers were used as substrates, unexpected N-hydroxyimide ester derivatives were obtained in moderate to excellent yields. To further understand this unusual transformation, control experiments were performed and a plausible mechanism was proposed.