Gold layer-based dual crosslinking procedure of glucose oxidase with ferrocene monocarboxylic acid provides a stable biosensor

Ganesan, Natarajan; Gadre, Anand; Paranjape, Makarand; Currie, J. F.

doi:10.1016/j.ab.2005.04.018

Cited by 20 publications

(16 citation statements)

References 10 publications

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“…Finally, the mediator must be stable in both of its oxidation states indefinitely for the mediation to continue [25,26]. Ferrocene and its derivatives are examples of mediators that are frequently used when constructing glucose electrochemical sensors since they have a wide range of redox potentials, are easy to derivatize, have fast electron transfer kinetics, and are stable in both the oxidized and reduced forms [25–27,31,39–44]. Examples of other redox mediators used with glucose oxidase based electrochemical sensors are given in Table 1.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Glucose Sensors—Developments Using Electrostatic Assembly and Carbon Nanotubes for Biosensor Construction

Harper

Anderson

2010

Sensors

140

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In 1962, Clark and Lyons proposed incorporating the enzyme glucose oxidase in the construction of an electrochemical sensor for glucose in blood plasma. In their application, Clark and Lyons describe an electrode in which a membrane permeable to glucose traps a small volume of solution containing the enzyme adjacent to a pH electrode, and the presence of glucose is detected by the change in the electrode potential that occurs when glucose reacts with the enzyme in this volume of solution. Although described nearly 50 years ago, this seminal development provides the general structure for constructing electrochemical glucose sensors that is still used today. Despite the maturity of the field, new developments that explore solutions to the fundamental limitations of electrochemical glucose sensors continue to emerge. Here we discuss two developments of the last 15 years; confining the enzyme and a redox mediator to a very thin molecular films at electrode surfaces by electrostatic assembly, and the use of electrodes modified by carbon nanotubes (CNTs) to leverage the electrocatalytic effect of the CNTs to reduce the oxidation overpotential of the electrode reaction or for the direct electron transport to the enzyme.

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Section: Introductionmentioning

confidence: 99%

Electrochemical Glucose Sensors—Developments Using Electrostatic Assembly and Carbon Nanotubes for Biosensor Construction

Harper

Anderson

2010

Sensors

140

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“…For the negative ion analysis, the Sand AuSsignals were very strong. Figure 8 shows the mass spectra of the product of the second modification process, SC 10 The working principles and the fabrication procedures of an energy generation system based on bio-electro-chemical reactions in a microfluidic platform have been presented. Surface characterization by SIMS was done after each fabrication step to ensure that the necessary chemicals were attached on the surface of the electrodes.…”

Section: Resultsmentioning

confidence: 99%

“…(2)]. It is reported that most of the redox enzymes lack of direct electrical communication between the electrode supports [7], thus, mediators such as ferrocenemethanol [8], dimethylaminomethylferrocene [9], ferrocene monocarboxylic acid [10] and gold nanoparticles [11] have been investigated as the bridge and the path of transporting the electrons from the redox center to the electrodes. Different mediators would result in different electron transfer rate.…”

Section: Introductionmentioning

confidence: 99%

Development of a bio-energy generation system based on microfluidic platform

Chau

Leung

et al. 2008

2008 International Conference on Information and Automation

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This paper reports the development of a bioenergy generation system -using microfluidic platform for processing the electrochemical energy conversion and storage inside a cell. The cell is designed to consist of two modified gold electrodes and glucose as the electrolyte. Electrical energy is generated by redox reaction through the process of glucose oxidation and oxygen reduction. The entire chemical reaction process is designed to take place between the cathode and anode without a proton exchange membrane. A thickness-controlled PDMS is used to form the fluidic channel for transporting the glucose solution. We have thus far completed the fabrication of the micro-bio-reaction system, and the electrodes were characterized secondary ion mass spectrometry (SIMS) to prove the adhesion of the necessary chemicals and proteins for bioelectrical-reaction.

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“…This paper examines the effect of a hydrogel membrane layer on the dynamic electrochemical behavior of a model electroactive species and well-known enzyme redox mediator, ferrocene monocarboxylic acid [26,27], at microdisk array electrodes. Aspects of electron transfer (ET) and mass transport in the presence and absence of the hydrogel layer was examined using Multiple Scan Rate Cyclic Voltamme-try (MSRCV).…”

Section: Introductionmentioning

confidence: 99%

Bioactive Hydrogel Layers on Microdisk Electrode Arrays: Cyclic Voltammetry Experiments and Simulations

2009

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Poly(hydroxyethylmethacrylate)-based hydrogel membranes were applied to microfabricated, microdisk electrode arrays (MDEAs) of 50 mm (5184 disks), 100 mm (1296 disks) and 250 mm (207 disks) (d/r ¼ 4; A ¼ 0.1 cm 2 ) and studied by cyclic voltammetry (CV) in 1.0 mM ferrocene monocarboxylic acid (FcCO 2 H). The membrane produced an order of magnitude decrease in current densities and a shift to quasi reversibility due to a decrease in the

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Gold layer-based dual crosslinking procedure of glucose oxidase with ferrocene monocarboxylic acid provides a stable biosensor

Cited by 20 publications

References 10 publications

Electrochemical Glucose Sensors—Developments Using Electrostatic Assembly and Carbon Nanotubes for Biosensor Construction

Electrochemical Glucose Sensors—Developments Using Electrostatic Assembly and Carbon Nanotubes for Biosensor Construction

Development of a bio-energy generation system based on microfluidic platform

Bioactive Hydrogel Layers on Microdisk Electrode Arrays: Cyclic Voltammetry Experiments and Simulations

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