Gold liposomes for brain-targeted drug delivery: Formulation and brain distribution kinetics

Sonkar, Roshan; Sonali,; Jha, Abhishek; Viswanadh, Matte Kasi; Burande, Ankita Sanjay; Narendra,; Pawde, Datta Maroti; Patel, Krishna Kumar; Singh, Manoj Kumar; Koch, Biplob; Muthu, Madaswamy S

doi:10.1016/j.msec.2020.111652

Cited by 31 publications

(20 citation statements)

References 32 publications

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“…Among them, hydrophobic NIRNs are inserted within the lipid bilayer, while hydrophilic NIRNs are encapsulated into the aqueous core or conjugated on the outer surface (Figure 3) [11]. As shown in Table 1, different methods have been used to prepare NIRNs that possess stable liposomal structures and high fluorescence intensity, including thin-film hydration, solvent injection, ultrasonication, hydrothermal method, ionic interaction assembly method, and extrusion method [84,[88][89][90][91][92]. Unencapsulated NIRNs were removed through several purification technologies such as dialysis, ultrafiltration, and ultracentrifugation [11].…”

Section: Preparation Methods and Encapsulation Strategy Of Nirn-lipsmentioning

confidence: 99%

“…More importantly, CUR in the liposome-AuNP system was unaffected in eight hours, while free CUR or CUR-Lips without AuNPs decoction showed a certain degradation [109]. Over the past decade, some preparing methods such as solvent injection, ultrasonication, and hydrothermal method have also been developed to prepare NIRN-Lips [89,91,110,111]. Nevertheless, in terms of particle size uniformity and structural stability, NIRN-Lips prepared by the thin film dispersion method still have irreplaceable advantages.…”

Section: Preparation Methods and Encapsulation Strategy Of Nirn-lipsmentioning

confidence: 99%

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Design and Application of Near-Infrared Nanomaterial-Liposome Hybrid Nanocarriers for Cancer Photothermal Therapy

et al. 2021

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Liposomes are attractive carriers for targeted and controlled drug delivery receiving increasing attention in cancer photothermal therapy. However, the field of creating near-infrared nanomaterial-liposome hybrid nanocarriers (NIRN-Lips) is relatively little understood. The hybrid nanocarriers combine the dual superiority of nanomaterials and liposomes, with more stable particles, enhanced photoluminescence, higher tumor permeability, better tumor-targeted drug delivery, stimulus-responsive drug release, and thus exhibiting better anti-tumor efficacy. Herein, this review covers the liposomes supported various types of near-infrared nanomaterials, including gold-based nanomaterials, carbon-based nanomaterials, and semiconductor quantum dots. Specifically, the NIRN-Lips are described in terms of their feature, synthesis, and drug-release mechanism. The design considerations of NIRN-Lips are highlighted. Further, we briefly introduced the photothermal conversion mechanism of NIRNs and the cell death mechanism induced by photothermal therapy. Subsequently, we provided a brief conclusion of NIRNs-Lips applied in cancer photothermal therapy. Finally, we discussed a synopsis of associated challenges and future perspectives for the applications of NIRN-Lips in cancer photothermal therapy.

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Section: Preparation Methods and Encapsulation Strategy Of Nirn-lipsmentioning

confidence: 99%

Section: Preparation Methods and Encapsulation Strategy Of Nirn-lipsmentioning

confidence: 99%

Design and Application of Near-Infrared Nanomaterial-Liposome Hybrid Nanocarriers for Cancer Photothermal Therapy

et al. 2021

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“…The newest reports [75,76] suggest using liposomes in the area of imaging diagnostics and treatment in neurology. However, it is worth mentioning that the interest in this topic started much earlier when Vieira et al presented a wide review summarizing accomplishments in the field of liposome-based drug delivery across the blood-brain barrier [77].…”

Section: Medical Imagingmentioning

confidence: 99%

“…Comparing various medical topics using liposomal delivery systems for imaging and therapy, oncology is the area with the biggest collection of data referring to its broad application. Liposome-nanoparticle hybrids that include metallic components such as: gold nanoparticles [75,81] or gadolinium nanoparticles (GdNPs) [63,82,83], and ultrasuperand superparamagnetic iron oxide nanoparticles (SPIONs)-called magnetoliposomes (MLs) [60,84,85]-can serve in the visualization of the cancer tissues using CT and MRI. Liposome-based CAs incorporating gadolinium were the first introduced nanostructure that has been widely used in various systems [86][87][88].…”

Section: Medical Imagingmentioning

confidence: 99%

The Combination of Liposomes and Metallic Nanoparticles as Multifunctional Nanostructures in the Therapy and Medical Imaging—A Review

Musielak

Potoczny

Boś-Liedke

et al. 2021

IJMS

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Nanotechnology has introduced a new quality and has definitely developed the possibilities of treating and diagnosing various diseases. One of the scientists’ interests is liposomes and metallic nanoparticles (LipoMNPs)—the combination of which has introduced new properties and applications. However, the field of creating hybrid nanostructures consisting of liposomes and metallic nanoparticles is relatively little understood. The purpose of this review was to compile the latest reports in the field of treatment and medical imaging using of LipoMNPs. The authors focused on presenting this issue in the direction of improving the used conventional treatment and imaging methods. Most of all, the nature of bio-interactions between nanostructures and cells is not sufficiently taken into account. As a result, overcoming the existing limitations in the implementation of such solutions in the clinic is difficult. We concluded that hybrid nanostructures are used in a very wide range, especially in the treatment of cancer and magnetic resonance imaging. There were also solutions that combine treatments with simultaneous imaging, creating a theragnostic approach. In the future, researchers should focus on the description of the biological interactions and the long-term effects of the nanostructures to use LipoMNPs in the treatment of patients.

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“…Liposomes are extensively used as carriers for numerous molecules in the cosmetic and pharmaceutical industries 13,14 .…”

Section: Sangam Singhmentioning

confidence: 99%

Method Development and Characterization of Liposomal Formulation of Isotretinoin

Ahmad¹,

Kumar²,

Singh³

et al. 2021

Borneo J Pharm

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This study aims to develop a liposomal drug delivery system of isotretinoin, an acne drug-using spray drying, as a cost-effective and time-effective technique. The liposomal formulation was prepared by using spray drying; three different strategies were adopted: suspension spray drying (SSD), thin-film hydration and spray drying (TFHSD), and emulsion spray drying (ESD). Isotretinoin was 99% bound with lipid, so lipids hydrogenated soy phosphatidylcholine (HSPC), distearoyl phosphatidylglycerol (DSPG), and cholesterol were selected for the formulation development. The HSPC, DSPG, cholesterol, and isotretinoin were taken in the ratio 4 : 1 : 0.16 : 3.1 mmol. In vitro drug release studies, microscopy, drug content, and related substance characterizations were done to formulate each strategy of spray drying prepared dry liposomes of isotretinoin. Results were compared with the USP monograph of isotretinoin. It was revealed that isotretinoin's liposomal formulation using ESD was having drug release according to the USP limits. Drug content was also according to the USP requirement; no free drug crystals were found in microscopy, multivesicular vesicles were found in shape, a particle size of up 60 µ was found. The ESD technique was a successful, time-effective, and cost-effective technique for preparing a liposomal drug delivery system for isotretinoin.

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Gold liposomes for brain-targeted drug delivery: Formulation and brain distribution kinetics

Cited by 31 publications

References 32 publications

Design and Application of Near-Infrared Nanomaterial-Liposome Hybrid Nanocarriers for Cancer Photothermal Therapy

Design and Application of Near-Infrared Nanomaterial-Liposome Hybrid Nanocarriers for Cancer Photothermal Therapy

The Combination of Liposomes and Metallic Nanoparticles as Multifunctional Nanostructures in the Therapy and Medical Imaging—A Review

Method Development and Characterization of Liposomal Formulation of Isotretinoin

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