Gold-modified paper as microfluidic substrates with reduced biofouling in potentiometric ion sensing

Ding, Ruiyu; Joon, Narender Kumar; Ahamed, Ashiq; Shafaat, Atefeh; Guzinski, Marcin; Wagner, Markus Robert; Ruzgas, Tautgirdas; Bobacka, Johan; Lisak, Grzegorz

doi:10.1016/j.snb.2021.130200

Cited by 25 publications

(18 citation statements)

References 69 publications

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“…The analytical efficacy of the developed electrochemical sensor for the determination of copper ions has been also demonstrated by applying it to the determination of copper ions in serum. A potential issue is given by the adsorption of proteins that are contained in serum, and a possible strategy to limit this possibility is the porosity of the paper itself and/or the combination of paper-based substrates with AuNPs. , However, it should be noted that for the present study, an all-in-one approach has been adopted. The serum sample has been drop cast onto a chromatographic paper and not on the office paper where the electrodes are printed.…”

Section: Resultsmentioning

confidence: 99%

Sustainable Copper Electrochemical Stripping onto a Paper-Based Substrate for Clinical Application

et al. 2022

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The electroanalytical field has exploited great advantages in using paper-based substrates, even if the word "paper" might be general. In fact, the mainly adopted paper-based substrates are often chromatographic and office ones. They are characterized by the following main features (and drawbacks): chromatographic paper is well-established for storing reagents/ treating samples, but the sensitivity compared to traditional screen-printed ones is lower (due to porosity), while office paper represents a sustainable alternative to plastic (with similar sensitivity), but its porosity is not enough to load reagents. To overcome the limitations that might arise due to the adoption of a type of individual paper-based substrate, herein, we describe for the first time the development of a two-dimensional merged paper-based device for electrochemical copper ion detection in serum. In this work, we report a novel configuration to produce an integrated all-in-one electrochemical device, in which no additional working medium has to be added by the end user and the sensitivity can be tuned by rapid preconcentration on porous paper, with the advantage of making the platform adaptable to real matrix scenarios. The novel architecture has been obtained by combining office paper to screen-print a sustainable and robust electrochemical strip and a chromatographic disk to (1) store the reagents, (2) collect real samples, and (3) preconcentrate the analyte of interest. The novel sensing platform has allowed us to obtain a detection limit for copper ions down to 4 ppb in all the solutions that have been investigated, namely, standard solutions and serum, and a repeatability of ca. 10% has been obtained. Inductively coupled plasma-mass spectrometry measurements confirmed the satisfactory correlation.

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Section: Resultsmentioning

confidence: 99%

Sustainable Copper Electrochemical Stripping onto a Paper-Based Substrate for Clinical Application

et al. 2022

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“…This is a significant advantage as the device is ready to use for detection of K + and Na + ions unlike other paper-based ISEs that require a pre-conditioning step (∼4-18 h). 25,44 pH test and response time…”

Section: Optimization Of Conditioning Time For the Isesmentioning

confidence: 99%

“…Ding et al presented a gold-modified paper for potentiometric detection of K + , Na + and Cl − in clinical samples. 25 PEDOT(PSS) and PEDOT(Cl) were electrochemically deposited on electrode surface as the ion-to-electron transducer for fabrication of solid-contact ISEs. It was observed that the modification of the paper substrates with gold nanoparticles improved the accuracy of the ISEs in samples.…”

Section: Introductionmentioning

confidence: 99%

Dual-mode ion-selective electrodes and distance-based microfluidic device for detection of multiple urinary electrolytes

Phoonsawat

Özer

Dungchai

et al. 2022

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“…it requires only a small sample volume and allows analysis of samples consisting of high solid-to-liquid ratios. [15][16][17][18][19][20] However, the use of paper-based microfluidic solution sampling coupled with potentiometric sensors poses some challenges when the target analytes are heavy metals. 21,22 The interactions of heavy metal ions with negatively charged groups commonly present in cellulose cause a deviation from the usual Nernstian response of the ISEs.…”

Section: Introductionmentioning

confidence: 99%

Ion-selective membrane modified microfluidic paper-based solution sampling substrates for potentiometric heavy metal detection

Silva

Zhao

Ding

et al. 2022

Analyst

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Gold-modified paper as microfluidic substrates with reduced biofouling in potentiometric ion sensing

Cited by 25 publications

References 69 publications

Sustainable Copper Electrochemical Stripping onto a Paper-Based Substrate for Clinical Application

Sustainable Copper Electrochemical Stripping onto a Paper-Based Substrate for Clinical Application

Dual-mode ion-selective electrodes and distance-based microfluidic device for detection of multiple urinary electrolytes

Ion-selective membrane modified microfluidic paper-based solution sampling substrates for potentiometric heavy metal detection

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