Gold nanocluster &amp; indocyanine green based triple-effective therapy for MRSA infected central nervous system

Zhuo, Yi; Zhang, Yi; Wang, Bing; Cheng, Shiqi; Yuan, Raorao; Liu, Shaowen; Zhao, Mailin; Xu, Bin; Zhang, Yan; Wang, Xiaolei

doi:10.1016/j.apmt.2022.101453

Cited by 9 publications

(10 citation statements)

References 38 publications

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“…Therefore, with their positive surface charge, QA-coated Au NCs can penetrate the BBB quickly and efficiently. [220] Metal NCs were used for brain imaging in the NIR-IIa range (1300-1400 nm) in normal, LPS-injured, and ischemic stroke mouse models. Initial observations in healthy mice revealed that arterial vessels were visible at the onset of brain perfusion.…”

Section: Biodistribution In Specific Organsmentioning

confidence: 99%

Multiscale Bioresponses of Metal Nanoclusters

Shi,

Wu,

et al. 2024

Advanced Materials

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Metal nanoclusters (NCs) are well‐recognized novel nano‐agents that hold great promise for applications in nanomedicine because of their ultrafine size, low toxicity, and high renal clearance. As foreign substances, however, an in‐depth understanding of the bioresponses to metal NCs is necessary but is still far from being realized. Herein, this review is deployed to summarize the biofates of metal NCs at various biological levels, emphasizing their multiscale bioresponses at the molecular, cellular, and organismal levels. In the parts‐to‐whole schema, the interactions between biomolecules and metal NCs are discussed, presenting typical protein‐dictated nano–bio interfaces, hierarchical structures, and in vivo trajectories. Then, the accumulation, internalization, and metabolic evolution of metal NCs in the cellular environment and as‐imparted theranostic functionalization are demonstrated. The organismal metabolism and transportation processes of the metal NCs are subsequently distilled. Finally, this review ends with the conclusions and perspectives on the outstanding issues of metal NC‐mediated bioresponses in the near future. This review is expected to provide inspiration for tailoring the customization of metal NC‐based nano‐agents to meet practical requirements in different sectors of nanomedicine.

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Section: Biodistribution In Specific Organsmentioning

confidence: 99%

Multiscale Bioresponses of Metal Nanoclusters

Shi,

Wu,

et al. 2024

Advanced Materials

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“…For modulating tumor hypoxia and enhancing cancer PDT and radiation therapy (RT). Zhuo et al 143 combined quaternary ammonium salt modified gold nanoclusters (QA) with ICG (QAI). Under the irradiation of NIR laser, QAI can effectively treat intracranial bacterial infections through a triple synergistic therapy of direct kill (DK), PTT, and PDT.…”

Section: Combination Therapymentioning

confidence: 99%

Biomolecule-protected gold nanoclusters: synthesis and biomedical applications

Hao

Zhang

et al. 2023

J. Mater. Chem. B

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“…For example, Zhuo et al. combined ICG with quaternary ammonium salt-modified AuNCs based on the minimum particle size (2 nm) and the positive surface charge of modified AuNCs, which can efficiently penetrate the blood–brain barrier and generate ROS and heat simultaneously under 808 nm NIR radiation to effectively treat intracranial methicillin-resistant Staphylococcus aureus infection …”

Section: Auncs In Combination Therapymentioning

confidence: 99%

“…For example, Zhuo et al combined ICG with quaternary ammonium salt-modified AuNCs based on the minimum particle size (2 nm) and the positive surface charge of modified AuNCs, which can efficiently penetrate the blood− brain barrier and generate ROS and heat simultaneously under 808 nm NIR radiation to effectively treat intracranial methicillin-resistant Staphylococcus aureus infection. 84 PTT can quickly and efficiently kill tumor cells or tissues by converting NIR light energy into heat by using PTAs. However, uneven heat distribution in tumor tissue due to laser attenuation or an inhomogeneous PS distribution significantly weakens the efficiency of PTT.…”

Section: Auncs In Combination Therapymentioning

confidence: 99%

A Review on Gold Nanoclusters for Cancer Phototherapy

Yang,

Guo

et al. 2023

ACS Appl. Bio Mater.

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Cancer phototherapy, including photodynamic therapy (PDT) and photothermal therapy (PTT), has been extensively studied in recent years because of its noninvasive properties, high efficiency, improved selectivity, and reduced side effects. Gold nanoclusters (AuNCs) have the advantages of high biocompatibility, high biosafety, excellent photoresponse, and high tumor penetration ability. This review analyzes the use of AuNCs in tumor phototherapy in recent years from three aspects, namely, AuNCs in PDT, AuNCs in PTT, and AuNCs in combination therapy, and presents the high potential of AuNCs in cancer phototherapy. This review aims to provide readers with the unique advantages, diversified application approaches, and bright application prospects of AuNCs in phototherapy and to provide insights into strategies for applying AuNCs to tumor phototherapy.

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Gold nanocluster & indocyanine green based triple-effective therapy for MRSA infected central nervous system

Cited by 9 publications

References 38 publications

Multiscale Bioresponses of Metal Nanoclusters

Multiscale Bioresponses of Metal Nanoclusters

Biomolecule-protected gold nanoclusters: synthesis and biomedical applications

A Review on Gold Nanoclusters for Cancer Phototherapy

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