Gold nanomaterials as a new tool for bioanalytical applications of laser desorption ionization mass spectrometry

Pilolli, Rosa; Palmisano, Francesco; Cioffi, Nicola

doi:10.1007/s00216-011-5120-2

Cited by 74 publications

(88 citation statements)

References 95 publications

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“…Silver salt was used in laser desorption/ionization (LDI) by depositing a small layer of AgNO 3 for the analysis of hydrocarbons in oil [14,15]. In the past few years, several reviews demonstrated growing interest in silver nanoparticles (AgNP) [16] and gold nanoparticles (AuNP) [17] to facilitate LDI. AgNP were previously used in surface-assisted laser desorption imaging (SALDI) [18,19] for drug analysis.…”

Section: Introductionmentioning

confidence: 99%

Laser Desorption/Ionization Mass Spectrometric Imaging of Endogenous Lipids from Rat Brain Tissue Implanted with Silver Nanoparticles

Muller

Baldwin

Barbacci

et al. 2017

J. Am. Soc. Mass Spectrom.

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Mass spectrometry imaging (MSI) of tissue implanted with silver nanoparticulate (AgNP) matrix generates reproducible imaging of lipids in rodent models of disease and injury. Gas-phase production and acceleration of size-selected 8 nm AgNP is followed by controlled ion beam rastering and soft landing implantation of 500 eV AgNP into tissue. Focused 337 nm laser desorption produces high quality images for most lipid classes in rat brain tissue (in positive mode: galactoceramides, diacylglycerols, ceramides, phosphatidylcholines, cholesteryl ester, and cholesterol, and in negative ion mode: phosphatidylethanolamides, sulfatides, phosphatidylinositol, and sphingomyelins). Image reproducibility in serial sections of brain tissue is achieved within <10% tolerance by selecting argentated instead of alkali cationized ions. The imaging of brain tissues spotted with pure standards was used to demonstrate that Ag cationized ceramide and diacylglycerol ions are from intact, endogenous species. In contrast, almost all Ag cationized fatty acid ions are a result of fragmentations of numerous lipid types having the fatty acid as a subunit. Almost no argentated intact fatty acid ions come from the pure fatty acid standard on tissue. Graphical Abstract ᅟ.

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Section: Introductionmentioning

confidence: 99%

Laser Desorption/Ionization Mass Spectrometric Imaging of Endogenous Lipids from Rat Brain Tissue Implanted with Silver Nanoparticles

Muller

Baldwin

Barbacci

et al. 2017

J. Am. Soc. Mass Spectrom.

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“…Gold clusters provide simple and fast determination of accurate mass compared with common calibration standards, such as peptides or proteins. Moreover, AuNPs can enhance ionization in various techniques, such as surface-assisted laser desorption ionization (SALDI), nanoparticle-assisted laser desorption ionization (NALDI), and gold nanoparticle-assisted laser desorption ionization (GALDI) [20][21][22]. The structure and properties of gold and phosphorus clusters are well known [23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Clusters of Monoisotopic Elements for Calibration in (TOF) Mass Spectrometry

Kolářová

Prokeš

Kučera

et al. 2016

J. Am. Soc. Mass Spectrom.

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Abstract. Precise calibration in TOF MS requires suitable and reliable standards, which are not always available for high masses. We evaluated inorganic clusters of the monoisotopic elements gold and phosphorus (Au n + /Au n -and P n + /P n -) as an alternative to peptides or proteins for the external and internal calibration of mass spectra in various experimental and instrumental scenarios. Monoisotopic gold or phosphorus clusters can be easily generated in situ from suitable precursors by laser desorption/ionization (LDI) or matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS). Their use offers numerous advantages, including simplicity of preparation, biological inertness, and exact mass determination even at lower mass resolution. We used citrate-stabilized gold nanoparticles to generate gold calibration clusters, and red phosphorus powder to generate phosphorus clusters. Both elements can be added to samples to perform internal calibration up to mass-to-charge (m/z) 10-15,000 without significantly interfering with the analyte. We demonstrated the use of the gold and phosphorous clusters in the MS analysis of complex biological samples, including microbial standards and total extracts of mouse embryonic fibroblasts. We believe that clusters of monoisotopic elements could be used as generally applicable calibrants for complex biological samples.

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“…Applications to several structural types 97 (Pilolli et al, 2012) Short general review on characterization of mainly acidic glycans GAGs N-links, glycan arrays 224 ) Application of surface plasmon resonance for the detection of carbohydrates and glycoconjugates Section on MALDI and in combination with SPR 201 (Safina, 2012) TLC/HPTLC with mass spectrometric detection A review of the progress in the last 5 years 98 Thin-layer chromatography and mass spectrometry for the separation and detection of large and small biomolecules Several compound typescarbohydrates peptides etc. 228 (Tuzimski, 2011) -on-aReview of reactions performed on MALDI plates.…”

Section: Theorymentioning

confidence: 99%

Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for 2011–2012

Harvey

2015

Mass Spectrometry Reviews

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This review is the seventh update of the original article published in 1999 on the application of MALDI mass spectrometry to the analysis of carbohydrates and glycoconjugates and brings coverage of the literature to the end of 2012. General aspects such as theory of the MALDI process, matrices, derivatization, MALDI imaging, and fragmentation are covered in the first part of the review and applications to various structural types constitute the remainder. The main groups of compound are oligo- and poly-saccharides, glycoproteins, glycolipids, glycosides, and biopharmaceuticals. Much of this material is presented in tabular form. Also discussed are medical and industrial applications of the technique, studies of enzyme reactions, and applications to chemical synthesis. © 2015 Wiley Periodicals, Inc. Mass Spec Rev 36:255-422, 2017.

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Gold nanomaterials as a new tool for bioanalytical applications of laser desorption ionization mass spectrometry

Cited by 74 publications

References 95 publications

Laser Desorption/Ionization Mass Spectrometric Imaging of Endogenous Lipids from Rat Brain Tissue Implanted with Silver Nanoparticles

Laser Desorption/Ionization Mass Spectrometric Imaging of Endogenous Lipids from Rat Brain Tissue Implanted with Silver Nanoparticles

Clusters of Monoisotopic Elements for Calibration in (TOF) Mass Spectrometry

Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for 2011–2012

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