Gold Nanomaterials at Work in Biomedicine

Yang, Xuan; Yang, Miaoxin; Pang, Bo; Vara, Madeline; Xia, Younan

doi:10.1021/acs.chemrev.5b00193

Cited by 1,047 publications

(808 citation statements)

References 764 publications

(1,739 reference statements)

Supporting

Mentioning

796

Contrasting

Unclassified

Order By: Relevance

“…As shown in Figure 1g, the BP nanosheets exhibit a typical broad absorption band spanning the ultraviolet and NIR regions similar to other 2D layered materials 53, 54. The extinction coefficient of the BP nanosheets is 31.4 Lg −1 cm −1 according to Beer's law,55 which is larger than those of most reported photothermal nanomaterials such as Au nanorods, GO nanosheets, WS 2 nanosheets, and BP quantum dots 56, 57, 58, 59…”

Section: Resultsmentioning

confidence: 78%

Black‐Phosphorus‐Incorporated Hydrogel as a Sprayable and Biodegradable Photothermal Platform for Postsurgical Treatment of Cancer

et al. 2018

View full text Add to dashboard Cite

Photothermal therapy (PTT) is a fledgling therapeutic strategy for cancer treatment with minimal invasiveness but clinical adoption has been stifled by concerns such as insufficient biodegradability of the PTT agents and lack of an efficient delivery system. Here, black phosphorus (BP) nanosheets are incorporated with a thermosensitive hydrogel [poly(d,l‐lactide)‐poly(ethylene glycol)‐poly(d,l‐lactide) (PDLLA‐PEG‐PDLLA: PLEL)] to produce a new PTT system for postoperative treatment of cancer. The BP@PLEL hydrogel exhibits excellent near infrared (NIR) photothermal performance and a rapid NIR‐induced sol–gel transition as well as good biodegradability and biocompatibility in vitro and in vivo. Based on these merits, an in vivo PTT postoperative treatment strategy is established. Under NIR irradiation, the sprayed BP@PLEL hydrogel enables rapid gelation forming a gelled membrane on wounds and offers high PTT efficacy to eliminate residual tumor tissues after tumor removal surgery. Furthermore, the good photothermal antibacterial performance prevents infection and this efficient and biodegradable PTT system is very promising in postoperative treatment of cancer.

show abstract

Section: Resultsmentioning

confidence: 78%

Black‐Phosphorus‐Incorporated Hydrogel as a Sprayable and Biodegradable Photothermal Platform for Postsurgical Treatment of Cancer

et al. 2018

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

“…[1][2][3][4][5][6][7][8] It has been shown that AgNPs exhibit highly antimicrobial activity against both Gram-positive and -negative bacteria. [1][2][3][4][5][6][7][8] They have also shown to be effective antiviral agents. [1][2][3][4][5][6][7][8][9] The size, morphology, and stability of NPs are known to strongly affect their antimicrobial and antiviral activity.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3][4][5][6][7][8] They have also shown to be effective antiviral agents. [1][2][3][4][5][6][7][8][9] The size, morphology, and stability of NPs are known to strongly affect their antimicrobial and antiviral activity. [1][2][3][4][5][6][7][8] Colloidal NPs are known to undergo coagulation and aggregation in solution, which, in turn, lead to changes in their size and morphology and, hence, their antibacterial and antiviral properties.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3][4][5][6][7][8][9] The size, morphology, and stability of NPs are known to strongly affect their antimicrobial and antiviral activity. [1][2][3][4][5][6][7][8] Colloidal NPs are known to undergo coagulation and aggregation in solution, which, in turn, lead to changes in their size and morphology and, hence, their antibacterial and antiviral properties. It is, therefore, important to develop an effective and reliable method to anchor the NPs to a supporting material in order to prevent their coagulation and aggregation, so that they can maintain their activity.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

One-Pot Synthesis of Biocompatible Silver Nanoparticle Composites from Cellulose and Keratin: Characterization and Antimicrobial Activity

Tran

Prosenc

Franko

et al. 2016

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

A novel, simple method was developed to synthesize biocompatible composites containing 50% cellulose (CEL) and 50% keratin (KER) and silver in the form of either ionic (Ag + ) or Ag 0 nanoparticles (Ag + NPs or Ag 0 NPs). In this method, butylmethylimmidazolium chloride ([BMIm + Cl -]), a simple ionic liquid, was used as the sole solvent and silver chloride was added to the [BMIm + Cl -] solution of [CEL+KER] during the dissolution process. The silver in the composites can be maintained as ionic silver (Ag + ) or completely converted to metallic silver (Ag 0 ) by reducing it with NaBH4. The results of spectroscopy [Fourier transform infrared and X-ray diffraction (XRD)] and imaging [scanning electron microscopy (SEM)] measurements confirm that CEL and KER remain chemically intact and homogeneously distributed in the composites. Powder XRD and SEM results show that the silver in the [CEL+KER+Ag + ] and [CEL+KER+Ag 0 ] composites is homogeneously distributed throughout the composites in either Ag + (in the form of AgClNPs) or Ag 0 NPs form with sizes of 27 ± 2 or 9 ± 1 nm, respectively. Both composites were found to exhibit excellent antibacterial activity against many bacteria including Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, methicillin-resistant S. aureus (MRSA), and vancomycin-resistant Enterococus faecalis (VRE). The antibacterial activity of both composites increases with the Ag + or Ag 0 content in the composites. More importantly, for the same bacteria and the same silver content, the [CEL+KER+AgClNPs] composite is relatively more toxic than [CEL+KER+Ag 0 NPs] composite. Experimental results confirm that there was hardly any Ag 0 NPs release from the [CEL+KER+Ag 0 NPs] composite, and hence its antimicrobial activity and NOT THE PUBLISHED VERSION; this is the author's final, peer-reviewed manuscript. The published version may be accessed by following the link in the citation at the bottom of the page. Vol 8, No. 50 (2016): pg. 34791-34801. DOI. This article is © American Chemical Society and permission has been granted for this version to appear in e-Publications@Marquette. American Chemical Society does not grant permission for this article to be further copied/distributed or hosted elsewhere without the express permission from American Chemical Society. ACS Applied materials & Interfaces,3 biocompatibility is due not to any released Ag 0 NPs but rather entirely to the Ag 0 NPs embedded in the composite. Both AgClNPs and Ag 0 NPs were found to be toxic to human fibroblasts at higher concentration (>0.72 mmol), and for the same silver content, the [CEL+KER+AgClNPs] composite is relatively more toxic than the [CEL+KER+Ag 0 NPs] composite. As expected, by lowering the Ag 0 NPs concentration to 0.48 mmol or less, the [CEL+KER+Ag 0 NPs] composite can be made biocompatible while still retaining its antimicrobial activity against bacteria such as E. coli, S. aureus, P. aeruginosa, MRSA, and VRE. These results, together with our previous finding that [CEL+KER] composites can ...

show abstract

Graphene‐Based Nanocomposite Materials for the Design of Electrochemical Sensors and Their Applications

Sheng

Qiao

Zhou³

et al. 2019

Handbook of Graphene

View full text Add to dashboard Cite

Gold Nanomaterials at Work in Biomedicine

Cited by 1,047 publications

References 764 publications

Black‐Phosphorus‐Incorporated Hydrogel as a Sprayable and Biodegradable Photothermal Platform for Postsurgical Treatment of Cancer

Black‐Phosphorus‐Incorporated Hydrogel as a Sprayable and Biodegradable Photothermal Platform for Postsurgical Treatment of Cancer

One-Pot Synthesis of Biocompatible Silver Nanoparticle Composites from Cellulose and Keratin: Characterization and Antimicrobial Activity

Graphene‐Based Nanocomposite Materials for the Design of Electrochemical Sensors and Their Applications

Contact Info

Product

Resources

About