Gold nanomaterials functionalised with gadolinium chelates and their application in multimodal imaging and therapy

Perry, Hannah L.; Botnar, René M.; Wilton‐Ely, James D. E. T.

doi:10.1039/d0cc00196a

Cited by 25 publications

(25 citation statements)

References 104 publications

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“…[1][2][3][4][5][6][7] As such, theranostic molecules are mainly constituted of an imaging unit combined to a therapeutic agent within the same platform. They can be divided into two families: i) nanoparticles and/or macromolecular materials/polymers in which the diagnostic and therapeutic units are adsorbed, conjugated, or aggregated; [8][9][10][11][12][13][14][15][16] ii) dual molecules, incorporating two distinct units (through a covalent bonding) for diagnosis and therapy. [17][18][19][20][21] These multifunctional molecules operate intracellularly and can be activated by external stimuli such as light.…”

Section: Introductionmentioning

confidence: 99%

Modified Indulines: From Dyestuffs to In Vivo Theranostic Agents

Chen

Pascal

Daurat³

et al. 2021

ACS Appl. Mater. Interfaces

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The efficient, versatile and straightforward synthesis of the first N-alkyl analogs of induline 3B (8a and 8b) is reported. Thanks to the introduction of lipophilic substituents and its attractive photophysical properties (far-red emission and production of singlet oxygen), phenazinium 8b can be used as theranostic agent and shows, at very low concentration (100 nM), a remarkable ability to: i) image cells and zebrafish embryos with high quality under both mono (514 nm) and biphotonic (790 and 810 nm) excitations, ii) efficiently and quickly penetrate cancer cells rather than healthy fibroblast, iii) induce a total or almost total cancer cell death in vitro and in vivo after illumination (exc = 540-560 nm). The molecular structure of 8b is based on a triamino-phenazinium core only, with no need for additional components, highlighting the emergence of a minimalistic and versatile class of fluorescent probes for targeted photodynamic cancer therapy.

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Section: Introductionmentioning

confidence: 99%

Modified Indulines: From Dyestuffs to In Vivo Theranostic Agents

Chen

Pascal

Daurat³

et al. 2021

ACS Appl. Mater. Interfaces

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“…CT, FUS and MR imaging can easily detect AuNPs [167]. MR imaging can detect and monitor cancerous and tumorous tissues by utilizing AuNPs, as they are biocompatible and easily tunable [168].…”

Section: Metallic Npsmentioning

confidence: 99%

Nanomaterials for Diagnosis and Treatment of Brain Cancer: Recent Updates

et al. 2020

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Brain tumors, especially glioblastoma, remain the most aggressive form of all the cancers because of inefficient diagnosis and profiling. Nanostructures, such as metallic nanostructures, silica nano-vehicles, quantum dots, lipid nanoparticles (NPs) and polymeric NPs, with high specificity have made it possible to permeate the blood–brain barrier (BBB). NPs possess optical, magnetic and photodynamic properties that can be exploited by surface modification, bio composition, contrast agents’ encapsulation and coating by tumor-derived cells. Hence, nanotechnology has brought on a revolution in the field of diagnosis and imaging of brain tumors and cancers. Recently, nanomaterials with biomimetic functions have been introduced to efficiently cross the BBB to be engulfed by deep skin tumors and cancer malignancies for imaging. The review focuses on nanotechnology-based diagnostic and imaging approaches for exploration in brain tumors and cancers. Moreover, the review also summarizes a few strategies to image glioblastoma and cancers by multimodal functional nanocomposites for more precise and accurate clinical diagnosis. Their unique physicochemical attributes, including nanoscale sizes, larger surface area, explicit structural features and ability to encapsulate diverse molecules on their surface, render nanostructured materials as excellent nano-vehicles to cross the blood–brain barrier and convey drug molecules to their target region. This review sheds light on the current progress of various kinds of nanomaterials, such as liposomes, nano-micelles, dendrimers, carbon nanotubes, carbon dots and NPs (gold, silver and zinc oxide NPs), for efficient drug delivery in the treatment and diagnosis of brain cancer.

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“…Thanks to the biocompatibility and tuneable morphology, AuNPS have been frequently used in clinical applications. In recent years, they have been exploited to create very promising tools for multimodal imaging and MRI-guided therapies [45]. To estimate the performance of GdCP and Au@GdCP as MRI contrast agent, the relaxation rate and T 1 -weighted MRI were investigated in vitro at the low eld of 0.5T.…”

Section: Relaxation Information and T 1 -Weighted Mri Mapsmentioning

confidence: 99%

Enhancing Resonance Imaging Sensitivity and Upconversion Emission of Gd-based Nanoscale Coordination Polymers by Combination With Au Nanoparticles

Xiao¹,

Change²,

Li³

et al. 2021

Preprint

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Nanoscale coordination polymers (NCPs) are attracting increasing research interest due to their highly tailorable structure, feasible functionality and promising application in various fields, especially in biomedical applications, they are excellent contrast agents for bioimaging, biosensing and clinical diagnosis. Currently, to overcome the low relaxation rate and unitary information of magnetic resonance imaging, the design of multifunction contrast agent is critical and challenging. Herein, a new Au nanoparticles/Gd-based coordination polymer (Au@GdCP) composite nanoparticles have been fabricated by a facile hydrothermal methodology. The Au@GdCP exhibit excellent magnetic resonance, bright upconversion luminescence (UC) and good biocompatibility. More importantly, with the introduction of Au nanoparticles, the magnetization and longitudinal relaxation rate (r1) of the nanocomposite is enhanced significantly, with 131.6-fold from 5.19 emu/g to 683.52 emu/g and 11.5 fold from 0.248 mM–1S–1 to 2.853 mM–1S–1 enhancement, respectively, as well as better UC property over GdCPs. This work may offer a new way to develop multifunctional NCPs with enhanced performance in image-guided diagnosis and therapy.

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Gold nanomaterials functionalised with gadolinium chelates and their application in multimodal imaging and therapy

Abstract: An overview of recent progress in the design of gadolinium-functionalised gold nanoparticles for use in MRI, multimodal imaging and theranostics.

Cited by 25 publications

References 104 publications

Modified Indulines: From Dyestuffs to In Vivo Theranostic Agents

Modified Indulines: From Dyestuffs to In Vivo Theranostic Agents

Nanomaterials for Diagnosis and Treatment of Brain Cancer: Recent Updates

Enhancing Resonance Imaging Sensitivity and Upconversion Emission of Gd-based Nanoscale Coordination Polymers by Combination With Au Nanoparticles

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