Gold Nanoparticle-Enhanced and Roll-to-Roll Nanoimprinted LSPR Platform for Detecting Interleukin-10

Baek, Seung Hee; Song, Hyun Woo; Lee, Sunwoong; Kim, Jung-Eun; Kim, Yeo Hyang; Wi, Jung‐Sub; Ok, Jong G.; Park, Jun Seok; Hong, Seonki; Kwak, Moon Kyu; Lee, Hye Jin; Nam, Sung-Wook

doi:10.3389/fchem.2020.00285

Cited by 23 publications

(14 citation statements)

References 26 publications

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“…IL-10 detection antibody was subsequently immobilized on the strip surface. Colloidal Au nanocube (AuNC) was used to enhance the LSPR signal and the assay with AuNC crosslinked with IL-10 antibody demonstrates the sensitivity of detection at the nanomolar level [72]. In another study, a cytokine detection device using AuNP-modified silica optical fiber was developed to monitor locally variable concentrations of cytokine IL-6.…”

Section:  Gold Nanoparticles (Aunps)mentioning

confidence: 99%

Advances in Nanotechnology-Based Biosensing of Immunoregulatory Cytokines

2021

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Cytokines are a large group of small proteins secreted by immune and non-immune cells in response to external stimuli. Much attention has been given to the application of cytokines’ detection in early disease diagnosis/monitoring and therapeutic response assessment. To date, a wide range of assays are available for cytokines detection. However, in specific applications, multiplexed or continuous measurements of cytokines with wearable biosensing devices are highly desirable. For such efforts, various nanomaterials have been extensively investigated due to their extraordinary properties, such as high surface area and controllable particle size and shape, which leads to their tunable optical emission, electrical, and magnetic properties. Different types of nanomaterials such as noble metal, metal oxide, and carbon nanoparticles have been explored for various biosensing applications. Advances in nanomaterial synthesis and device development have led to significant progress in pushing the limit of cytokine detection. This article reviews currently used methods for cytokines detection and new nanotechnology-based biosensors for ultrasensitive cytokine detection.

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Section:  Gold Nanoparticles (Aunps)mentioning

confidence: 99%

Advances in Nanotechnology-Based Biosensing of Immunoregulatory Cytokines

2021

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“…Gold cubic nanoparticles were also investigated with respect to the oxygen reduction reaction deposited on a disc electrode . The unusual properties resulting from the regular shape of the AuNCs allow the application of localized surface plasmon resonance (LSPR) techniques for detecting biomolecules. , Today, AuNCs may be used for the preparation of label-free electrochemical aptasensors and immunosensors. AuNCs were deposited on a gold substrate in a multistage modification with cysteamine and, after aptamer immobilization, used for sensitive and selective chloramphenicol detection .…”

Section: Introductionmentioning

confidence: 99%

Deciphering the Molecular Mechanism of Substrate-Induced Assembly of Gold Nanocube Arrays toward an Accelerated Electrocatalytic Effect Employing Heterogeneous Diffusion Field Confinement

et al. 2022

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The complex electrocatalytic performance of gold nanocubes (AuNCs) is the focus of this work. The faceted shapes of AuNCs and the individual assembly processes at the electrode surfaces define the heterogeneous conditions for the purpose of electrocatalytic processes. Topographic and electron imaging demonstrated slightly rounded AuNC (average of 38 nm) assemblies with sizes of ≤1 μm, where the dominating patterns are (111) and (200) crystallographic planes. The AuNCs significantly impact the electrochemical performance of the investigated electrode [indium–tin oxide (ITO), glassy carbon (GC), and bulk gold] systems driven by surface electrons promoting the catalytic effect. Cyclic voltammetry in combination with scanning electrochemical microscopy allowed us to decipher the molecular mechanism of substrate-induced electrostatic assembly of gold nanocube arrays, revealing that the accelerated electrocatalytic effect should be attributed to the confinement of the heterogeneous diffusion fields with tremendous electrochemically active surface area variations. AuNC drop-casting at ITO, GC, and Au led to various mechanisms of heterogeneous charge transfer; only in the case of GC did the decoration significantly increase the electrochemically active surface area (EASA) and ferrocyanide redox kinetics. For ITO and Au substrates, AuNC drop-casting decreases system dimensionality rather than increasing the EASA, where Au–Au self-diffusion was also observed. Interactions of the gold, ITO, and GC surfaces with themselves and with surfactant CTAB and ferrocyanide molecules were investigated using density functional theory.

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“…Gold cubic nanoparticles were also investigated toward the oxygen reduction reaction deposited on a disc electrode 33 . The unusual properties resulting from the regular shape of the AuNCs allow the application of localized surface plasmon resonance (LSPR) techniques for detecting biomolecules 34,35 . Nowadays, AuNCs may be used for the preparation of label-free electrochemical aptasensors and immunosensors.…”

Section: Introductionmentioning

confidence: 99%

Deciphering the molecular mechanism of substrate-induced assembling of gold nanocube arrays toward accelerated electrocatalytic effect employing heterogeneous diffusion fields confinement

Niedziałkowski

Koterwa

Olejnik

et al. 2022

Preprint

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The complex electrocatalytic performance of gold nanocubes (AuNCs) is the focus of the presented paper. The faceted shapes of AuNCs and the individual assembling process at the electrode surfaces define heterogeneous conditions for the purpose of electrocatalytic processes. Topographic and electron imaging demonstrated slightly rounded AuNC (avg. 38 nm) assemblies with sizes up to 1 µm, where the dominating patterns are (111) and (200) crystallographic planes. The AuNCs significantly impact the electrochemical performance of the investigated electrode (ITO, GC, bulk gold) systems driven by surface electrons promoting the catalytic effect. Cyclic voltammetry jointly with scanning electrochemical microscopy (SECM) allowed us to decipher the molecular mechanism of substrate-induced electrostatic assembling of gold nanocube arrays, revealing that the accelerated electrocatalytic effect should be attributed to the confinement of the heterogeneous diffusion fields with tremendous electrochemically active surface area variations. The AuNC drop-casting at ITO, GC, and Au led to various mechanisms of heterogeneous charge transfer, where only in the case of GC, the decoration significantly increased both the electrochemically active surface area (EASA) and ferrocyanide redox kinetics. For ITO and Au substrates, AuNC drop-casting lowers system dimensionality rather than expanding the EASA, where Au-Au self-diffusion was also observed. Interactions between the gold, ITO, and GC surfaces with themselves and with surfactant CTAB and ferrocyanide molecules were investigated by performing density functional theory.

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Gold Nanoparticle-Enhanced and Roll-to-Roll Nanoimprinted LSPR Platform for Detecting Interleukin-10

Cited by 23 publications

References 26 publications

Advances in Nanotechnology-Based Biosensing of Immunoregulatory Cytokines

Advances in Nanotechnology-Based Biosensing of Immunoregulatory Cytokines

Deciphering the Molecular Mechanism of Substrate-Induced Assembly of Gold Nanocube Arrays toward an Accelerated Electrocatalytic Effect Employing Heterogeneous Diffusion Field Confinement

Deciphering the molecular mechanism of substrate-induced assembling of gold nanocube arrays toward accelerated electrocatalytic effect employing heterogeneous diffusion fields confinement

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