Gold nanoparticle-glutathione functionalized MOFs as hydrophilic materials for the selective enrichment of glycopeptides

Design and Optimization of a Self-Assembling Complex Based on Microencapsulated Calcium Alginate and Glutathione (CAG) Using Response Surface Methodology

“…Glutathione is a water-soluble, natural tripeptide composed of N -γ-glutamyl-cysteine-glycine that has a considerable number of free hydrophilic, amino, and carboxylic acid groups [ 5 , 6 ]. It is the most abundant antioxidant at the cellular level [ 7 ] and has the ability to form complexes with metals, thus limiting their catalytic activity [ 8 , 9 ] and moderating oxidative stress [ 5 , 7 ]. Glutathione has been shown to protect against phenolic oxidation, anthocyanin loss, and flavor decay in foods and beverages by reacting with quinones [ 2 , 3 , 4 , 10 ].…”

Bioinspired Mesoporous Silica for Cd(II) Removal from Aqueous Solutions

“…Their efficiency comes from the high number of donor atoms in their peptide backbone or in the amino acid chain and, for the proteins, from their geometry. Metal binding of thiol-rich biological compounds such as glutathione (GSH) or cysteine has been widely studied, and these ligands are now arising into glycopeptide enrichment, adsorption, and metal detection research studies. − …”

A novel hydrophilic MOFs-303-functionalized magnetic probe for the highly efficient analysis of N-linked glycopeptides

“…Recently, metal-organic framework (MOF) composites with hydrophilicity show tremendous potential in glycopeptide enrichment due to designable structures, tunable pore sizes and functionalities. [14][15][16] Liu et al developed a maltosefunctionalized hydrophilic MIL-101(Cr)-NH 2 for the detection of glycopeptides, and captured 111 glycopeptides assigned to 65 glycoproteins in 5 mL human serum. 17 Deng et al prepared a hydrophilic glutathione-functionalized magnetic UiO-66-NH 2 for glycopeptide enrichment, and enriched 273 glycopeptides corresponding to 94 glycoproteins in 2 mL of human serum.…”