Gold Nanoparticle Mediated Phototherapy for Cancer

Yao, Cuiping; Zhang, Luwei; Wang, Jing; He, Yulu; Jing, Xin; Wang, Sijia; Xu, Hao; Zhang, Zhenxi

doi:10.1155/2016/5497136

Cited by 84 publications

(84 citation statements)

References 204 publications

(259 reference statements)

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“…Dextran is readily soluble in water and electrolytes with excellent stability and it has wide range of use in food, medical related areas, and biological functions, especially for blood flow improvement by reduction of blood viscosity and inhibition of erythrocyte aggregation [30,31]. Therefore, dextran stabilized AuNPs are promising to use for intravenous administration as X-ray contrast agent [16,32], cancer therapy [33,34] including photothermal cancer therapy [35,36], and for other purposes of application as well [23].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Gold Nanoparticles Stabilized in Dextran Solution by Gamma Co-60 Ray Irradiation and Preparation of Gold Nanoparticles/Dextran Powder

Diem

Thao

Phú

et al. 2017

Journal of Chemistry

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Gold nanoparticles (AuNPs) in spherical shape with diameter of 6-35 nm stabilized by dextran were synthesized by -irradiation method. The AuNPs were characterized by UV-Vis spectroscopy and transmission electron microscopy. The influence of pH, Au 3+ concentration, and dextran concentration on the size of AuNPs was investigated. Results indicated that the smallest AuNPs size (6 nm) and the largest AuNPs size (35 nm) were obtained for pH of 1 mM Au 3+ /1% dextran solution of 5.5 and 7.5, respectively. The smaller Au 3+ concentration favored smaller size and conversely the smaller dextran concentration favored bigger size of AuNPs. AuNPs powders were prepared by spay drying, coagulation, and centrifugation and their sizes were also evaluated. The purity of prepared AuNPs powders was also examined by energy dispersive X-ray (EDX) analysis. Thus, the as-prepared AuNPs stabilized by biocompatible dextran in solution and/or in powder form can be potentially applied in biomedicine and pharmaceutics.

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Section: Introductionmentioning

confidence: 99%

Synthesis of Gold Nanoparticles Stabilized in Dextran Solution by Gamma Co-60 Ray Irradiation and Preparation of Gold Nanoparticles/Dextran Powder

Diem

Thao

Phú

et al. 2017

Journal of Chemistry

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“…Biofunctionalization of gold nanoparticles techniques are well-known procedures for biomedical technologies both in vitro and in vivo [13,14]. Gold nanoparticles conjugates with specific antibodies for breast cancer have been recently used for hyperthermia in order to increase the specificity in anticancer treatments [8,[14][15][16]. Experimental neuro-oncology demands the creation of appropriate animal models to assess the efficacy of innovate approaches for the treatment of human tumors.…”

Section: Introductionmentioning

confidence: 99%

Slowdown intracranial glioma progression by optical hyperthermia therapy: study on a CT-2A mouse astrocytoma model

Casanova-Carvajal¹,

Urbano-Bojorge²,

Ramos³

et al. 2019

Nanotechnology

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Metallic nanorods are promising agents for a wide range of biomedical applications. We report an optical hyperthermia method capable of inducing slowdown tumor progression of an experimental in vivo CT-2A glioblastoma tumor. The tumor model used in this research is based on the transplantation of mouse astrocytoma CT-2A cells in the striatum of mice by intracranial stereotaxic surgery. Two weeks after cell implant, the resulting tumor is treated by irradiating intratumoral injected gold nanorods, biofunctionalized with CD 133 antibody (B-GNRs), using a continuous wave laser. Nanoparticles convert the absorbed light into localized heat (reaching up to 44 °C) due to the effect of surface plasmon resonance. A significant slowdown in CT-2A tumor progression is evident, by histology and magnetic resonance imaging, at one (p = 0.03) and two weeks (p = 0.008) after irradiation treatment. A notable deceleration in tumor size (15%-75%) as compared to the control untreated groups, it is observed. Thus, laser irradiation of B-GNRs is found to be effective for the treatment of CT-2A tumor progression. Similarities between the pre-clinical CT-2A tumor model and the human astrocytoma disease, in terms of anatomy, metastatic behavior and histopathology, suggest that hyperthermic treatment by laser irradiation of B-GNRs administered into high-grade human astrocytoma might constitute a promising alternative treatment to limit the progression of this deadly disease.

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“…Se observó que los valores de temperatura de control y de sílice son mayores cuando se aplica 1 W, sin embargo para los grupos de nanorods y sílice más nanorods se alcanzó la hipertermia elevando la temperatura hasta un valor aproximado de 44 ºC tal y como sugiere la literatura [2], [20], [21], [57], [80]. Dicho valor es suficiente para matar células cancerígenas, reduciendo las concentraciones de oro en las muestras, tiempos de irradiación del laser y potencia irradiada del mismo, lo que constituye un avance en la técnica de hipertermia óptica mediada por nanopartículas de oro utilizando material dispersante de luz altamente biocompatible como lo es el sílice.…”

Section: Hipertermia óPticaunclassified

“…Existe una gran cantidad de tipos de nanopartículas de oro, como nanoesferas de oro que se consideran las más básicas de todas las GNP, nanocables de oro que están hechos de un núcleo de sílice y una capa de oro que los rodean, nanoestrellas de oro y nanorods de oro (GNR) usados en los experimentos, siendo los GNP los de sección transversal de absorción más alta entre todas las nano formulaciones de oro, debido a su longitud de onda de dos aspectos, longitudinal y transversal, cuya variación de relación ajusta su absorción dentro de NIR y son conocidas por su pequeño tamaño, entre 20 nm y 40 nm[3],[5],[12].Sin embargo, con el fin de aumentar el efecto de transformación de luz a calor, un elemento adyacente tuvo que ser introducido con los GNR, un componente que posee las características ópticas deseadas para la hipertermia óptica, en estos experimentos la sustancia utilizada fue sílice (SiO2), que es una forma oxidada de silicio[18],[19].Estas micropartículas de dióxido de silicio son la base de una gran cantidad de investigaciones biomédicas debido a su estabilidad, baja toxicidad y capacidad de funcionalizarse con una gama de moléculas y polímeros[20], lo que también lo hace apto para mezclarse con tejidos biológicos. Como las células de glioma de ratón CT2A.La biofuncionalización de las técnicas de nanopartículas de oro son procedimientos bien conocidos para las tecnologías biomédicas tanto in vitro como in vivo[7],[21]. Se han presentado recientemente en otros estudios las aplicaciones de nanopartículas de oro para hipertermia de ensayo con animales[8],[21][22][23].…”

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“…Como las células de glioma de ratón CT2A.La biofuncionalización de las técnicas de nanopartículas de oro son procedimientos bien conocidos para las tecnologías biomédicas tanto in vitro como in vivo[7],[21]. Se han presentado recientemente en otros estudios las aplicaciones de nanopartículas de oro para hipertermia de ensayo con animales[8],[21][22][23]. Particularmente, los tumores cerebrales en modelos animales permiten un mejor abordaje de la investigación preclínica, como se ha demostrado en el caso de la línea celular de glioblastoma CT-2A[2],[4],[24] que se utiliza en este trabajo como modelo tumoral.…”

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Contribución a las tecnologías hipertérmicas mediadas por nanopartículas para terapias anticancerígenas

Carvajal¹,

Simón²

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of the thesis of Oscar Ernesto Simon Casanova Carvajal, presented as partial requirement to obtain the DOCTOR degree in BIOMEDICAL ENGINEERING.Madrid, June 28 th, 2017. CONTRIBUTION TO HYPOTHERMAL TECHNIQUES MEDIATED BY NANOPARTICLES FOR ANTICANCERIC THERAPIESAbstract:After the fusion of nanotechnology with medicine and bioengineering, fields of research in nanomedicine and nanobioengineering were created, which broadened the perspective of medical research and emerging new frontiers. These investigations have allowed new methods of approach to find solutions to long-standing human biological problems and the development and administration of therapeutic or pharmacological diagnoses. To achieve this, nanoparticles have been developed, which are miniaturized agents, which have given way to nanomedicine. The gold nanoparticles used in this study are nanorods (GNR) coated with G protein, a common receptor for mechanically anchoring antibodies. In this research hyperthermia plays a role of greatest importance which refers to the application of heat to destroy malignant cells by induction of apoptosis through the denaturation of proteins and the rupture of cell membranes. The application of gold nanoparticles generated by optical hyperthermia improve in-vitro therapy, and considerable advances were made in-vivo for animal models. In magnetic hyperthermia, the conversion of electromagnetic energy into heat generated by SPIONs subjected to alternating magnetic fields (HAC) can be used to cause the death of tumour cells. Recent studies have shown that the magnetic response, and therefore the heating efficiency of SPIONs, are significantly reduced when these nanoparticles are placed in viscous carrier liquids and within living cells or biological tissues. The higher viscosity of the biological environment and the spatial distribution or agglomeration of nanoparticles within the intracellular organelles strongly influence the efficacy of SPIONs to increase the temperature of the surrounding medium. These factors that arise from the nanobio-interaction make the heating efficiency in in-vivo applications less efficient and predictable than in ideal ferrofluids. Considerable advances were made in both techniques, in optical hyperthermia it was included until obtaining improvements in the introduction of dispersant material and biocompatible light such as Silica. The results suggested a considerable improvement in all the variables involved in the system such as irradiated power, time of exposure to the laser, concentration of gold nanoparticles (nanorods) and maintaining the mortality rate in cancer cells (CT2A) against cell lines considered healthy (MC3T3). In the case of magnetic hyperthermia, an electronic system was designed and built to generate excitatory waveforms different from conventional ones (sinusoidal), tolerance tests were carried out on the nanoparticles that will be used in the system. Also, it was demonstrated the existing physical phenomenon when the SPIONs are phagocytized by the cells, applying an intrace...

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Gold Nanoparticle Mediated Phototherapy for Cancer

Cited by 84 publications

References 204 publications

Synthesis of Gold Nanoparticles Stabilized in Dextran Solution by Gamma Co-60 Ray Irradiation and Preparation of Gold Nanoparticles/Dextran Powder

Synthesis of Gold Nanoparticles Stabilized in Dextran Solution by Gamma Co-60 Ray Irradiation and Preparation of Gold Nanoparticles/Dextran Powder

Slowdown intracranial glioma progression by optical hyperthermia therapy: study on a CT-2A mouse astrocytoma model

Contribución a las tecnologías hipertérmicas mediadas por nanopartículas para terapias anticancerígenas

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