We have designed a flexible electrochemical
transducer film based
on PEDOT–titania–poly(dimethylsiloxane) (PTS) for the
simultaneous detection of neurotransmitters. PTS films were characterized
using various techniques such as transmission electron microscopy,
scanning electron microscopy, atomic force microscopy, four probe
electrical conductivity, ac-impedance, and thermomechanical stability.
The electrocatalytic behavior of the flexible PTS film toward the
oxidation of neurotransmitters was investigated using cyclic voltammetry
and differential pulse voltammetry. The fabricated transducer measured
a limit of detection of 100 nm ± 5 with a response time of 15
s and a sensitivity of 63 μA mM–1 cm–2. The fabricated transducer film demonstrated for the simultaneous
determination of epinephrine, dopamine, ascorbic acid, and uric acid
with no interference between the analyte molecules. Further, transducer
performance is validated by performing with real samples. The results
suggested that the fabricated flexible PTS transducer with superior
electrocatalytic activity, stability, and low response time can be
explored for the sensing of neurotransmitters and hence can be exploited
at in vitro and in vivo conditions for the early detection of the
various diseases.