Gold nanoparticles-based colorimetric and visual creatinine assay

He, Yi; Zhang, Xianhui; Yu, Haili

doi:10.1007/s00604-015-1546-0

Cited by 76 publications

(29 citation statements)

References 26 publications

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“…[19][20][21][22] Colorimetric methods using the LSPR of metal nanoparticles (MNPs, i.e., AuNPs and AgNPs) have attracted much attention due to the unique optical properties of these materials, which can be easily observed by a UV-vis spectrometer or the naked eye, while the metal surface can be modified for the selective detection of specific molecules. [23][24][25][26][27][28] Since AuNPs and AgNPs are the two most commonly used materials for this method, we focus on their use in creatinine detection. Here, the aggregation mechanisms of these plasmonic materials in the presence of creatinine are discussed in detail, with aggregation being their main principle.…”

Section: Chemical Diagnosis In Urine Using Plasmonic Nanomaterials 2•1 Creatininementioning

confidence: 99%

“…The use of citrate-capped AuNPs as a colorimetric probe has been demonstrated as a selective and sensitive method for determining creatinine levels. 23 The detection range of this system, which covers creatinine concentrations in the range of 0.1 -20.0 mM, was previously obtained as 80 μM in buffer solutions. The color of AuNP colloidal solutions changed from red to blue and the LSPR peak of the AuNPs shifted from 520 -670 nm due to AuNP aggregation in the presence of Kazunari SHINBO received the B.E., M.E.…”

Section: •1•1 Gold Nanoparticlesmentioning

confidence: 99%

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Colorimetric Detection Based on Localized Surface Plasmon Resonance for Determination of Chemicals in Urine

et al. 2020

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Colorimetric sensors based on localized surface plasmon resonance (LSPR) have attracted much attention for biosensor and chemical sensor applications. The unique optical effect of LSPR is based on the nanostructure of noble metals (e.g., Au, Ag, and Al) and the refractive index of the environment surrounding these metal nanomaterials. When either the structure or the environment of these nanomaterials is changed, their optical properties change and can be observed by spectroscopic techniques or the naked eye. Colorimetric-probe-based LSPR provides a simple, rapid, real-time, nonlabelled, sensitive biochemical detection and can be used for point-of-care testing as well as rapid screening for the diagnosis of various diseases. Gold and silver nanoparticles, which are the two most widely used plasmonic nanomaterials, demonstrate strong and sensitive LSPR signals that can be used for the selective detection of several chemicals in biochemical compounds provided by the human body (e.g., urine and blood). This information can be used for the diagnosis of several human health conditions. This paper provides information regarding colorimetric probes based on LSPR for the detection of three major chemicals in human urine: creatinine, albumin, and glucose. In addition, the mechanisms of selective detection and quantitative analysis of these chemicals using metal nanoparticles are discussed along with colorimetric-detection-based LSPR for many other specific chemicals that can be detected in urine, such as catecholamine neurotransmitters, thymine, and various medicines. Furthermore, issues regarding the use of portable platforms for health monitoring with colorimetric detection based on LSPR are discussed.

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Section: Chemical Diagnosis In Urine Using Plasmonic Nanomaterials 2•1 Creatininementioning

confidence: 99%

Section: •1•1 Gold Nanoparticlesmentioning

confidence: 99%

Colorimetric Detection Based on Localized Surface Plasmon Resonance for Determination of Chemicals in Urine

et al. 2020

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“…These techniques are mostly performed on blood samples, urine specimens, and even saliva samples, which are referred to in various articles 47 . It has also been observed that the results are improved by adding nanoparticles (NPs) to creatinine measuring methods 48–52 …”

Section: Introductionmentioning

confidence: 99%

Trend in creatinine determining methods: Conventional methods to molecular‐based methods

Narimani

Esmaeili

Rasta

et al. 2020

Analytical Science Advances

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Renal failure (RF) disease is ranked as one of the most prevalent diseases with severe morbidity and mortality. Early diagnosis of RF leads to subsequent control of disease to reduce the poor prognosis. The level of sera creatinine is considered as a significant biomarker for kidney biofunction, which is routinely detected by the Jaffe reaction. The normal range for creatinine in the blood may be 0.84‐1.21 mg/dL. Low accuracy, insufficient sensitivity, explosive and toxicity of picric acid, and pseudo‐interaction with nonspecific elements such as ammonium ions in the Jaffe method lead to the development of various techniques for precise detection of creatinine such as spectroscopic, electrochemical, and chromatography approaches and sensors based on enzymes, molecular imprinted polymer and nanoparticles, etc. Based on previously established results, they are trying to construct sensors with high accuracy, optimum sensitivity, acceptable linear/calibration range, and limit of detection, which are small in size and applicable by the patient him/herself (point‐of‐care testing). By comparing the results of research, a molecularly imprinted electrochemiluminescence‐based sensor with linear/calibration range of 5‐1 mM0.33emconcentration of creatinine and the detection limit of 0.5 nM has the best detectable resolution with 2 million measurable points. In this paper, we will review the recently developed methods for measuring creatinine concentration and renal biofunction.

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“…Creatinine (2-imino-1-methyl-2-imidazoline-4-ketone) is an important clinical analyte that is produced through muscle metabolism and removed by glomerular filtration. The physiological creatinine level of a healthy person is about 3.5 to 34.6 mM in urine and 50 to 140 μM in blood [1]. Furthermore, the deviation of the normal physiological creatinine level in urine or human blood within a long period of time indicates the dysfunction of human body, such as kidney problems or muscular disorders mostly.…”

Section: Introductionmentioning

confidence: 99%

“…Especially, gold nanoparticles (AuNPs) decorated with polymers or surfactants have been widely reported to be used as colorimetric sensors to detect numerous special target molecules in an accurate way [19,23,24,25,26,27]. In most cases, colorimetric detection mechanisms of AuNP probes are mostly attributed to the changes of AuNPs in the state of dispersion and aggregation, which are caused by the interaction between target bio-molecules or ions and decorators modified on AuNPs [1,23]. Recently, numerous PEG-based and PEG ligands have been reported as decorators for stable preparation of AuNPs sensors, due to their good water solubility, high colloidal stability, and excellent inhabitation of nonspecific adsorption of peptides and proteins [28,29].…”

Section: Introductionmentioning

confidence: 99%

Highly Sensitive and Selective Colorimetric Detection of Creatinine Based on Synergistic Effect of PEG/Hg2+–AuNPs

et al. 2019

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A colorimetric sensor, based on the synergistic coordination effect on a gold nanoparticle (AuNP) platform has been developed for the determination of creatinine. The sensor selects citrate stabilized AuNPs as a platform, polyethylene glycol (PEG) as a decorator, and Hg2+ as a linkage to form a colorimetric probe system (PEG/Hg2−–AuNPs). By forming hydrogen bond between the oxygen-containing functional groups of PEG and citrate ions on the surface of AuNPs, this probe shows good stability. PEG coordinated with Hg2+ synergistically and specifically on the surface of dispersed AuNPs, and the existence of creatinine could induce the aggregation of AuNPs with a corresponding color change and an obvious absorption peak shift within 5 min. This PEG/Hg2+–AuNPs probe towards creatinine shows high sensitivity, and a good linear relationship (R2 = 0.9948) was obtained between A620–522 nm and creatinine concentration, which can achieve the quantitative calculations of creatinine. The limit of detection (LOD) of this PEG/Hg2+–AuNPs probe was estimated to be 9.68 nM, lower than that of many other reported methods. Importantly, the sensitive probe can be successfully applied in a urine simulating fluid sample and a bovine serum sample. The unique synergistic coordination sensing mechanism applied in the designation of this probe further improves its high selectivity and specificity for the detection of creatinine. Thus, the proposed probe may give new inspirations for colorimetric detection of creatinine and other biomolecules.

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Gold nanoparticles-based colorimetric and visual creatinine assay

Cited by 76 publications

References 26 publications

Colorimetric Detection Based on Localized Surface Plasmon Resonance for Determination of Chemicals in Urine

Colorimetric Detection Based on Localized Surface Plasmon Resonance for Determination of Chemicals in Urine

Trend in creatinine determining methods: Conventional methods to molecular‐based methods

Highly Sensitive and Selective Colorimetric Detection of Creatinine Based on Synergistic Effect of PEG/Hg2+–AuNPs

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