Gold Nanoparticles from Ostruthin: Green Synthesis, a Stable Mechanism, Antitumor, and Antibacterial Activity

Abstract

The Ostruthin was extracted and identified its structure from rhizomes of Luvunga scandens located at Ta Cu Mountain, Binh Thuan province, Vietnam for the first time. Gold nanoparticles (AuNPs) were synthesized by the green method. The AuNPs acted as antitumor against breast cancer cell line (MCF-7), human liver cancer cell line (HepG2), and Non-Small Cell Lung (NCI-H460). They showed the potential antitumor activity against MCF-7 with the IC50 value of 65.47�3.09 �M. The antitumor activity of the AuNPs was also compared with the extracted constituents from the root of Luvunga Scandens in a previous article. The AuNPs were exposed to high antitumor activity against MCF-7 and Hep G2, human cancer cell lines. The AuNPs have also been tested the antibacterial activity and shown the moderate antibacterial activity on both Salmonella enterica and Bacillus subtilis at a concentration of 0.25 mM.

Retrospective analysis of the key molecules involved in the green synthesis of nanoparticles

“…Ostruthin isolated from the rhizome of Luvunga scandens showed moderate antibacterial activity against Salmonella enterica and B. subtilis at 0.25 mM concentration when used for AuNP synthesis. 88 Meanwhile, AuNPs synthesized using gymnemic acid (GA) (a secondary metabolite derived from Gymnema sylvestre ) had a size of 62.93 nm and a spherical shape, showing a cell viability of 56.67% at a concentration of 1000 μM in 3T3-L1 adipocytes. 89 In addition, adipocytes treated with GA-AuNPs showed a dose-dependent increase in glucose take up, indicating that they might be employed as a solution for the treatment of hyperglycemia (Fig.…”

Biosynthesis, and characterization of Zinc oxide nanoparticles (ZnONPs) obtained from the extract of waste of strawberry

“…The bottom-up method is applied for the synthesis of biogenic nanoparticles, mainly, in which atoms and compounds act as building blocks and self-assemble to build a final product [6]. Herein we described the green approach for synthesis different metal and metal oxide nanoparticles with their applications a better approach as compared to physical, chemical approach [7][8][9][10][11][12]. The significance of ZnONPs more interesting as compared to other metal oxide nanoparticles having diverse applications such as optical, piezoelectric, magnetic and gas sensing.…”