Gold nanoparticles prevent cognitive deficits, oxidative stress and inflammation in a rat model of sporadic dementia of Alzheimer's type

Müller, Alexandre Pastoris; Ferreira, Gabriela K.; Pires, Allison José; Silveira, Gustavo de Bem; Souza, Débora Laureano de; Brandolfi, Joice de Abreu; Souza, Cláudio Teodoro de; Paula, M.M.S.; Silveira, Paulo César Lock

doi:10.1016/j.msec.2017.03.283

Cited by 101 publications

(59 citation statements)

References 60 publications

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“…Specifically, treatment with AuNPs showed a significant reduction in the mRNA expression levels of TNF-α down to the normal levels as compared with the D group, indicating the effect of AuNPs on suppressing the inflammation through preventing TNF-α over expression. This result is consistent with other studies which described AuNP as an anti-inflammatory agent in different diseases including diabetes [14,[46][47][48].…”

Section: Discussionsupporting

confidence: 93%

Gold nanoparticles attenuate albuminuria by inhibiting podocyte injury in a rat model of diabetic nephropathy

Alomari

Al‐Trad

Hamdan

et al. 2019

Drug Deliv. and Transl. Res.

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Several recent studies have reported that gold nanoparticles (AuNPs) attenuate hyperglycemia in diabetic animal models without any observed side effects. The present study was intended to provide insight into the effects of 50nm AuNPs on diabetic kidney disease. Adult male rats were divided into three groups (n = 7/group): control (nondiabetic, ND), diabetic (D), and diabetic treated intraperitoneally with 50-nm AuNPs (AuNPs + D; 2.5 mg/kg/day) for 7 weeks. Diabetes was induced by a single-dose injection of 55 mg/kg streptozotocin. The result showed that AuNP treatment prevented diabetes-associated increases in the blood glucose level. Reduction in 24-h urinary albumin excretion rate, glomerular basement membrane thickness, foot process width, and renal oxidative stress markers was also demonstrated in the AuNP-treated group. In addition, the results showed downregulation effect of AuNPs in renal mRNA or protein expression of transforming growth factor β1 (TGF-β 1 ), fibronectin, collagen IV, tumor necrosis factor-α (TNF-α), and vascular endothelial growth factor-A (VEGF-A). Moreover, the protein expression of nephrin and podocin, podocyte markers, in glomeruli was increased in the AuNPs + D group compared with the D group. These results provide evidence that 50-nm AuNPs can ameliorate renal damage in experimental models of diabetic nephropathy through improving the renal function and downregulating extracellular matrix protein accumulation, along with inhibiting renal oxidative stress and amelioration of podocyte injury.

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Section: Discussionsupporting

confidence: 93%

Gold nanoparticles attenuate albuminuria by inhibiting podocyte injury in a rat model of diabetic nephropathy

Alomari

Al‐Trad

Hamdan

et al. 2019

Drug Deliv. and Transl. Res.

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“…The best results were obtained with the dose of 250 µg/kg as compared to animals with untreated oral mucositis (5-FU). The literature shows that AuNp treatment induced anti-inflammatory and analgesic activity in an experimental model of paw edema in Wistar rats [8], as well as preventing cognitive damage and oxidative stress by increasing levels of GSH in a mouse model with Alzheimer's disease [14]. Antioxidant systems are crucial for the body's defense against oxidative cellular damage.…”

Section: Discussionmentioning

confidence: 99%

“…However, the effect of AuNp on OM, as far as we know, has not been described in the literature. AuNp blocks the activation of NF-κB by interacting with IKK-β and inhibits the production of proinflammatory cytokines, such as TNF-α and IL-1β [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

“…In vitro studies have shown that AuNp elevates IL-10 cytokine levels, which partially explains its anti-inflammatory effect [13,14]. The literature also reports that AuNps may be involved in the regulation of the Kelch-like ECH-associated protein 1 (KEAP1)-nuclear factor E2-related factor 2 (NRF2) pathway, thus adjusting cytoprotective response to endogenous and exogenous stress caused by reactive oxygen species (ROS).…”

Section: Introductionmentioning

confidence: 99%

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Effect of Gold Nanoparticle on 5-Fluorouracil-Induced Experimental Oral Mucositis in Hamsters

et al. 2020

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Background: Oral mucositis (OM) is a severe inflammation of the oral mucosal cells associated with chemotherapy and/or radiotherapy-induced toxicity, resulting in epithelial ulcers and higher risk of death from sepsis. The aim of the present study was to evaluate the nanoparticle (AuNp) effect on OM induced in hamsters. Materials and methods: 5-fluorouracil (5FU) was used on the first and second day of the experimental model in Golden sirian hamsters, and on the fourth day, mechanical trauma was applied to induce OM. The animals were divided into groups, i.e., polyvinylpyrrolidone (PVP), mechanical trauma (MT), 5FU, and groups treated with gold nanoparticles (AuNps) (62.5, 125, and 250 μg/kg). On the 10th day, animals were euthanized for macroscopic, histopathological, immunohistochemical, western blot, quantitative polymerase chain reaction (qRT-PCR), and AuNp quantification. Results: AuNp (250 μg/kg) reduced TNF-α, IL-1β, COX-2, NF-κB, TGF-β, and SMAD 2/3; increased glutathione levels; decreased the expression of Kelch ECH-associated protein 1 (KEAP1); and induced heme oxygenase 1 (HMOX-1) and NAD (P) H quinone oxidoreductase 1 (NQO1) genes. Conclusions: AuNp (250 μg/kg) prevented 5-FU-induced OM in hamsters and improved the parameters of inflammation and oxidative stress.

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“…Production of ROS is normal process of cell physiology; however the presence of NM in cellular environment may disrupt it abruptly. The generation of ROS may have severe consequences, as their presence have been reported in various degenerative disease like Alzheimer's disease, Parkinson's disease, Arthritis, cancer, and many more …”

Section: Cellular and Molecular Toxicity Of Nanobiomaterialsmentioning

confidence: 99%

Rational approaches for toxicological assessments of nanobiomaterials

Pandey

Mishra

2019

J Biochem & Molecular Tox

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The nanobiomaterials display unique and distinguished usefulness in day-to-day life. The application of nanobiomaterials is being utilized in several segments, including semiconductor industries, cosmetics, and medicines. Alongside their usefulness these nanobiomaterials have potential toxicity which may limit it's further use. As there is sparse information on toxicological facets of nanomaterials available, a proactive approach for evaluation of potential risk of nanobiomaterials should be exercised. This review explains the potential mechanism of nanobiomaterials toxicity and rational approaches for selection of protocols to study toxicity of nanobiomaterials.

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Gold nanoparticles prevent cognitive deficits, oxidative stress and inflammation in a rat model of sporadic dementia of Alzheimer's type

Cited by 101 publications

References 60 publications

Gold nanoparticles attenuate albuminuria by inhibiting podocyte injury in a rat model of diabetic nephropathy

Gold nanoparticles attenuate albuminuria by inhibiting podocyte injury in a rat model of diabetic nephropathy

Effect of Gold Nanoparticle on 5-Fluorouracil-Induced Experimental Oral Mucositis in Hamsters

Rational approaches for toxicological assessments of nanobiomaterials

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