Gold Nanoparticles: Synthesis and Applications in Drug Delivery

Ak, Koray; Rashid, Rehana; Murtaza, Ghulam; Zahra, Alaee

doi:10.4314/tjpr.v13i7.23

Cited by 385 publications

(190 citation statements)

References 45 publications

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“…Hence, they have been extensively used in various biomedical applications and drug delivery systems due to their inert nature, small size and high surface area-to-volume ratio. [11] …”

Section: Gold Nanoparticlesmentioning

confidence: 99%

“…The common nanoparticles exemplified for the treatment of drug resistant cancer cells mainly include polymeric nanoparticles, liposomes, dendrimers, carbon nanotubes, nanoshells, magnetic nanoparticles (MNPs), and gold nanoparticles. [8,11,29,30] …”

Section: Active Targetingmentioning

confidence: 99%

“…[5,9] It precisely includes all the particles of size 1 billionth of a meter (<100 nm). [1,10,11] Thus, the main added advantage is that at this size range, nanoparticles possess a maximum surface:volume ratio, which makes them ideal for surface functionalization and incorporation of a chemotherapeutic load. [10,12] This smallest size is mainly responsible for the movement of the nanoparticles within the cells and tissues.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Nano drug delivery in oral cancer therapy: An emerging avenue to unveil

Dathar¹,

Dental²

2015

JMRPS

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Oral cancer is one of the most threatening diseases impairing the quality of life of the patient. Though many strategies are being employed for treatment of oral cancer, the eventual goal to cure cancer still remains elusive. Various drug delivery systems have been practiced to achieve better success in improving the survival rate of the patient. Until date, targeted drug delivery systems via nanoparticles are expected to be promising multi-functional platform in cancer therapeutics. The present article is a brief review of unique properties of nanoparticles and various nano drug delivery systems in oral cancer therapy.

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“…Hence, they have been extensively used in various biomedical applications and drug delivery systems due to their inert nature, small size and high surface area-to-volume ratio. [11] …”

Section: Gold Nanoparticlesmentioning

confidence: 99%

Section: Active Targetingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Nano drug delivery in oral cancer therapy: An emerging avenue to unveil

Dathar¹,

Dental²

2015

JMRPS

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show abstract

“…Overall, osteosarcoma has an incidence rate of 10-26 per million new cases worldwide each year [25]. Various side effects such as severe nausea, vomiting, nephrotoxicity, myelosuppression and neurotoxicity were noted after cisplatin administration, whereas gastrointestinal disturbances, acute nausea, vomiting, stomatitis, alopecia baldness, neurologic disturbances, bone marrow, aplasia, cumulative cardio toxicity and bone marrow depressant effects due to doxorubicin administration [26]. Because of these shortcomings, effective approaches with less or no side effects should be considered.…”

Section: Introductionmentioning

confidence: 99%

Flower-shaped gold nanoparticles synthesized using Kedrostis foetidissima and their antiproliferative activity against bone cancer cell lines

Firdhouse

Pottail

2016

Int J Ind Chem

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Three different methods were employed for the synthesis of biogenic gold nanoparticles using the aqueous extracts of Kedrostis foetidissima. The interaction of gold nanoparticles with the phytoconstituents was investigated by FTIR. The complete reduction of chloroaurate ions to gold nanoparticles was monitored using UV-visible spectroscopy under the different plant extract concentration and conditions. The formation of gold nanoparticles was confirmed using XRD, SEM and TEM analysis. The anisotropic and flower-shaped gold nanoparticles of size below 25 nm was confirmed by TEM analysis. Cucurbitacins, the chief constituents of K. foetidissima probably might have interacted with the chloroaurate ions, facilitating the formation of gold nanoparticles. KFL-mediated AuNPs showed 88 % cell viability against bone cancer cell lines at 200 lg/ml concentration using MTT assay. This may be due to the formation of flower-shaped nature of KFL-mediated AuNPs. The novelty of the work lies in the plantmediated synthesis of biocompatible gold nanoparticles of size less than 25 nm showing 88 % of cell viability against bone cancer cell lines.

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“…Generally, GNPs possess a large reactive and exposed surface area that enables bioconjugation with molecular probes, be it hydrophobic, hydrophilic, anionic, cationic or any neutral moieties [4].…”

Section: Introductionmentioning

confidence: 99%

Review of Applications and Environmental Fate of Gold Nanoparticles

Palaniappan¹

2018

International Conference of Recent Trends in Environmental Science and Engineering

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-The unique properties of nanomaterials do enable them to contribute significantly to environmental protection; however at the same time, they also have a significant negative impact on the environment as well as on living organisms. Among the existing nanomaterials, gold nanoparticle (GNP) is quickly gaining grounds due to its wide ranging uses in the field of medicine, especially radiation therapy and targeted drug delivery. Apparently, the increased production, application and disposal of GNPs have led to an increased release of nanogold into the environment and there are very few studies that bring out the implications of such release. This study aims to review various applications of GNPs and their fate in the environment.

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Gold Nanoparticles: Synthesis and Applications in Drug Delivery

Cited by 385 publications

References 45 publications

Nano drug delivery in oral cancer therapy: An emerging avenue to unveil

Nano drug delivery in oral cancer therapy: An emerging avenue to unveil

Flower-shaped gold nanoparticles synthesized using Kedrostis foetidissima and their antiproliferative activity against bone cancer cell lines

Review of Applications and Environmental Fate of Gold Nanoparticles

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