Gold nanorod assisted near-infrared plasmonic photothermal therapy (PPTT) of squamous cell carcinoma in mice

Abstract

Plasmonic photothermal therapy (PPTT) is a minimally-invasive oncological treatment strategy in which photon energy is selectively administered and converted into heat sufficient to induce cellular hyperthermia. The present work demonstrates the feasibility of in vivo PPTT treatment of deep-tissue malignancies using easily-prepared plasmonic gold nanorods and a small, portable, inexpensive near-infrared (NIR) laser. Dramatic size decreases in squamous cell carcinoma xenografts were observed for direct (P<0.0001) and intravenous (P<0.0008) administration of pegylated gold nanorods in nu/nu mice. Inhibition of average tumor growth for both delivery methods was observed over a 13-day period, with resorption of >57% of the directly-injected tumors and 25% of the intravenously-treated tumors.

Controllable Cobalt Oxide/Au Hierarchically Nanostructured Electrode for Nonenzymatic Glucose Sensing

“…Heat transfer from the nanoparticle to its surroundings, known as the photothermal effect, increases the local cell temperature which must reach a minimum of ∼40 • C for apoptosis to occur [189,[195][196][197]. Hyperthermia arises from a number of mechanisms, including cavitation effects caused by microbubble formation, disruption of cell membranes and denaturation of proteins [198][199][200].…”

“…Using nanoshells with a 110 nm silica core diameter and a 10 nm Au shell, the authors reported significant reduction of human breast carcinoma epithelial cells (SK-Br-3) both in vitro and in a mouse model. Since then there have been many accounts of laser initiated hyperthermia using a variety of nanoparticles with solid Au spheres, cubes, stars, shells and rods all demonstrating successful results in photothermal applications [119,167,189,197,[206][207][208][209][210][211][212].…”

Applications of gold nanorods in biomedical imaging and related fields

“…Norman et al [63] used antibody-conjugated GNRs to kill Pseudomonas aeruginosa bacterial cells under irradiation with 785 nm light. Dickerson et al [64] carried out the photothermal therapy of deeptissue malignancies using PEG-modified GNRs and found that GNRs were preferentially accumulated in tumor sites due to the enhanced permeability and retention (EPR) effect of tumor tissues. The resorption of tumor tissues by laser irradiation was above 57% for the direct injection of GNRs and about 25% for the intravenous injection of GNRs.In comparison, no tumor resorption was detected for all controls.…”

New ideally absorbing Au plasmonic nanostructures for biomedical applications

“…Solution of this problem is associated with the developing of Au nanoparticles having absorption peak lying within the biological transparency window. The absorption peak of Au nanorods [11,25,26,38] may be tuned from 550 nm up to 1µm by altering its aspect ratio. Another way is to utilize Au nanoshells with a high refractive index of core material (e.g., Si or SiO 2 ) [23,[39][40][41][42][43].…”