Gold nanorods as peroxidase mimetics and its application for colorimetric biosensing of malathion

Biswas, Sharmila; Tripathi, P.; Kumar, Nitin; Nara, Seema

doi:10.1016/j.snb.2016.03.066

Cited by 87 publications

(33 citation statements)

References 38 publications

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“…Most applications encompassed in this category are related to diagnostic tools to detect toxic contaminants in environmental waters. This mainly includes heavy metals [136,[176][177][178][179][180][181][182][183], pesticides [100,184,185] or micro-organisms [102,[186][187][188][189], for being the most common contaminants, but it could potentially include any others. Nonetheless, these are not the only examples of gold nanozyme applications in the environmental sector, especially since their catalytic activities started to be exploited for wastewater treatment to degrade or convert toxic molecules into innocuous products [190,191].…”

Section: Environmental Applicationsmentioning

confidence: 99%

Gold Nanozymes: From Concept to Biomedical Applications

et al. 2020

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In recent years, gold nanoparticles have demonstrated excellent enzyme-mimicking activities which resemble those of peroxidase, oxidase, catalase, superoxide dismutase or reductase. This, merged with their ease of synthesis, tunability, biocompatibility and low cost, makes them excellent candidates when compared with biological enzymes for applications in biomedicine or biochemical analyses. Herein, over 200 research papers have been systematically reviewed to present the recent progress on the fundamentals of gold nanozymes and their potential applications. The review reveals that the morphology and surface chemistry of the nanoparticles play an important role in their catalytic properties, as well as external parameters such as pH or temperature. Yet, real applications often require specific biorecognition elements to be immobilized onto the nanozymes, leading to unexpected positive or negative effects on their activity. Thus, rational design of efficient nanozymes remains a challenge of paramount importance. Different implementation paths have already been explored, including the application of peroxidase-like nanozymes for the development of clinical diagnostics or the regulation of oxidative stress within cells via their catalase and superoxide dismutase activities. The review also indicates that it is essential to understand how external parameters may boost or inhibit each of these activities, as more than one of them could coexist. Likewise, further toxicity studies are required to ensure the applicability of gold nanozymes in vivo. Current challenges and future prospects of gold nanozymes are discussed in this review, whose significance can be anticipated in a diverse range of fields beyond biomedicine, such as food safety, environmental analyses or the chemical industry.

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Section: Environmental Applicationsmentioning

confidence: 99%

Gold Nanozymes: From Concept to Biomedical Applications

et al. 2020

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“…Some of the strategies for pesticide detection are reliant on enzyme-like inhibition assays [ 138 , 139 , 140 ] or exploit the phosphatase-like activity for pesticide degradation [ 141 , 142 , 143 ]. Those that are based on the phosphatase-like activity are type I nanozymes involving nanoceria [ 141 , 142 , 143 ], whereas those based on the peroxidase-like activity are mainly type I Fe 3 O 4 nanoparticles [ 140 , 144 , 145 ] or type II metal particles [ 138 , 146 , 147 , 148 ].…”

Section: Detection Of Pesticidesmentioning

confidence: 99%

“…As a result, chlorpyrifos as low as 9.97 mg/L could be detected. In other work, Biswas et al [ 146 ] have shown that the peroxidase-like activity of gold nanorods can be inhibited by malathion by interacting with the surface of the nanorods. They hypothesised that the positive charge of the nanorod surface coated with cetyltrimethylammonium bromide had a high affinity for the sulfanyl group of malathion.…”

Section: Detection Of Pesticidesmentioning

confidence: 99%

Nanozymes for Environmental Pollutant Monitoring and Remediation

Wong¹,

Vuong²,

Chow³

2021

Sensors

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Nanozymes are advanced nanomaterials which mimic natural enzymes by exhibiting enzyme-like properties. As nanozymes offer better structural stability over their respective natural enzymes, they are ideal candidates for real-time and/or remote environmental pollutant monitoring and remediation. In this review, we classify nanozymes into four types depending on their enzyme-mimicking behaviour (active metal centre mimic, functional mimic, nanocomposite or 3D structural mimic) and offer mechanistic insights into the nature of their catalytic activity. Following this, we discuss the current environmental translation of nanozymes into a powerful sensing or remediation tool through inventive nano-architectural design of nanozymes and their transduction methodologies. Here, we focus on recent developments in nanozymes for the detection of heavy metal ions, pesticides and other organic pollutants, emphasising optical methods and a few electrochemical techniques. Strategies to remediate persistent organic pollutants such as pesticides, phenols, antibiotics and textile dyes are included. We conclude with a discussion on the practical deployment of these nanozymes in terms of their effectiveness, reusability, real-time in-field application, commercial production and regulatory considerations.

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“…Over the last decade, nanomaterials-based artificial enzymes, known as nanozymes have emerged as a powerful alternative to naturals enzymes in various applications ranging from pollutant removal, stem cell growth, cancer diagnostics and biosensing [13][14][15]. In the field of biosensing particularly, nanozyme-based peroxidase mimics involving the use of carbon-based nanomaterials [16][17][18][19], magnetic Fe 3 O 4 nanoparticles (MNPs) [19] and plasmonic nanoparticles NPs [20] as catalyst to catalyse the oxidation of a suitable substrate in the presence of hydrogen peroxide (H 2 O 2 ) have been exploited in several colorimetric assays [21][22][23]. Gold NPs (AuNPs), characterized by their surface plasmon resonance (SPR) absorption feature are known to change colour relative to their chemical state and this property has been exploited in colorimetric assays [24].…”

Section: Introductionmentioning

confidence: 99%