Gold Nanostructures on Flexible Substrates as Electrochemical Dopamine Sensors

Hsu, Ming Sheng; Chen, Yu Liang; Lee, Chi Young; Chiu, Hsin‐Tien

doi:10.1021/am301452b

Cited by 129 publications

(60 citation statements)

References 55 publications

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“…An abnormal level of dopamine may cause several central nervous system diseases such as depression, anxiety, schizophrenia, and Parkinson's disease [2][3][4][5]. Therefore, it is of great significance to detect dopamine accurately at a physiological level in the earlier prevention and clinical diagnosis of these neurological diseases.…”

Section: Introductionmentioning

confidence: 99%

“…MnO 2 , an important transition metal oxide, has been extensively used in rechargeable batteries [19], supercapacitors [20,21], electrocatalysis [22,23], and sensors [24][25][26][27][28], owing to its prominent advantages such as cheapness, low toxicity, and excellent electrocatalytic performances. Moreover, the electrochemical performance can be tailored by tuning the morphologies of nano-MnO 2 [25].…”

Section: Introductionmentioning

confidence: 99%

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Morphologically Tunable MnO2 Nanoparticles Fabrication, Modelling and Their Influences on Electrochemical Sensing Performance toward Dopamine

Liu

et al. 2018

Catalysts

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Abstract:The morphology or shape of nanomaterials plays an important role in functional applications, especially in the electrochemical sensing performance of nanocomposites modified electrodes. Herein, the morphology-dependent electrochemical sensing properties of MnO 2 -reduced graphene oxide/glass carbon electrode (MnO 2 -RGO/GCE) toward dopamine detection were investigated. Firstly, various morphologies of nanoscale MnO 2 , including MnO 2 nanowires (MnO 2 NWs), MnO 2 nanorods (MnO 2 NRs), and MnO 2 nanotubes (MnO 2 NTs), were synthesized under different hydrothermal conditions. Then the corresponding MnO 2 -RGO/GCEs were fabricated via drop-casting and the subsequent electrochemical reduction method. The oxidation peak currents increase with the electrochemical activity area following the order of MnO 2 NWs-RGO/GCE, MnO 2 NTs-RGO/GCE, and MnO 2 NRs-RGO/GCE. The spatial models for MnO 2 NWs, MnO 2 NTs, and MnO 2 NRs are established and accordingly compared by their specific surface area, explaining well the evident difference in electrochemical responses. Therefore, the MnO 2 NWs-RGO/GCE is selected for dopamine detection due to its better electrochemical sensing performance. The response peak current is found to be linear with dopamine concentration in the range of 8.0 × 10 −8 mol/L-1.0 × 10 −6 mol/L and 1.0 × 10 −6 mol/L-8.0 × 10 −5 mol/L with a lower detection limit of 1 × 10 −9 mol/L (S/N = 3). Finally, MnO 2 NWs-RGO/GCE is successfully used for the determination of dopamine injection samples, with a recovery of 99.6-103%. These findings are of great significance for understanding the relationship between unlimited nanoparticle structure manipulation and performance improvement.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Morphologically Tunable MnO2 Nanoparticles Fabrication, Modelling and Their Influences on Electrochemical Sensing Performance toward Dopamine

Liu

et al. 2018

Catalysts

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“…Therefore, accurate determination of DA in biological fluids are crucial to trace and diagnose diseases. Over the past few decades, researchers have studied the in vivo monitoring of the concentration of dopamine in environmental and biological samples, such as highperformance liquid chromatography [4,5], fluorescence spectrophotometry [6,7], and electrochemical methods [8,9]. Among them, the electrochemical method possesses a series of advantages including rapid response, low cost, simple operation and sensitivity.…”

Section: Introductionmentioning

confidence: 99%

Voltammetric dopamine sensor based on three-dimensional electrosynthesized molecularly imprinted polymers and polypyrrole nanowires

2017

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Three-dimensional structures comprising polypyrrole nanowires (PPyNWs) and molecularly imprinted polymer (MIP) were prepared by electropolymerization on the surfaces of a glassy carbon electrode (GCE). The modified GCE possesses both large surface area and good electrocatalytic activity for oxidizing dopamine (DA), and this leads to high sensitivity. The electropolymerized MIP has a large number of accessible surface imprints, and this makes the GCE more selective. Under optimal conditions and at a working voltage of typically 0.23 V (vs. SCE), the calibration plot is linear in the 50 nM to 100 μM DA concentration range, and the limit of detection is 33 nM. The sensor has been successfully applied to the analysis of DA in injections.

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“…Meanwhile, noble metal NPs modified electrodes have shown promising applications in the areas of catalysis, (electro)chemical analysis and biosensing due to their unique characters such as good conductivity, strong capacity to promote electronic transmission, high catalytic activity and high sensitivity and/or selectivity in electrochemical analysis [4][5][6][7]. For example, Au NPs can promote electrocatalytic reaction by accelerating electron transfer process in redox center.…”

Section: Introductionsmentioning

confidence: 99%

A facile method to prepare noble metal nanoparticles modified Self-Assembly (SAM) electrode

Liu

Huang

Duan

et al. 2017

Journal of Experimental Nanoscience

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Noble metal nanoparticles (NPs) modified electrodes have shown promising applications in the areas of catalysis, (electro)chemical analysis and biosensing due to their unique characters. In this paper, we introduced a so-called ligand exchange method to prepare self-assembly (SAM) electrode modified with noble metal nanoparticles. The noble metal nanoparticles protected by weakly adsorbed tetraoctylammonium bromide (TOAB) were synthesized firstly, then self-assembly (SAM) dithiol-modified Au electrode (Au-SH SAM ) was immersed into the solutions containing TOAB-protected nanoparticles. Due to the strong interaction between the dithiol groups on the electrode and noble metal nanoparticles, the weakly adsorbed TOAB on the surface of noble metal NPs were replaced by dithiol groups. As a result, the TOAB protected NPs were anchored on the Au-SH SAM template electrode surface by ligand exchange, obtaining noble metal NPs modified electrode with high quality and stability. By adjusting the soaking time, the coverage of nanoparticles on the Au-SH SAM electrode surface could be controlled. The morphology and distribution of noble metal NPs on Au-SH SAM surface was analysis by scanning tunneling microscope (STM), and their electrochemical property was studied by cyclic voltammetry (CV) in H 2 SO 4 solution. The approach is proved as a universal way to prepare noble metal NPs modified SAM electrode.

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Gold Nanostructures on Flexible Substrates as Electrochemical Dopamine Sensors

Cited by 129 publications

References 55 publications

Morphologically Tunable MnO2 Nanoparticles Fabrication, Modelling and Their Influences on Electrochemical Sensing Performance toward Dopamine

Morphologically Tunable MnO2 Nanoparticles Fabrication, Modelling and Their Influences on Electrochemical Sensing Performance toward Dopamine

Voltammetric dopamine sensor based on three-dimensional electrosynthesized molecularly imprinted polymers and polypyrrole nanowires

A facile method to prepare noble metal nanoparticles modified Self-Assembly (SAM) electrode

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