Abstract-The latest internet of everything (IoE) advancements in data elicitation and digital storage technology leads to a large heterogeneous data depository, in which the IoE data are stored in a column oriented relational framework. The main purposes of the research are to design and explore data models, frameworks, architectures, and algorithms on network-centric data, mainly IoE data to accomplish the data science and knowledge analytic tasks for Intellectual domain applications. Some storage incompatibilities are there in the relational structure of multi-objective IoE data base that creates threats to data integrity and consistency. In a large scale IoE database, huge numbers of rows are there along with limited number of columns. So, column oriented relational framework greatly improve the performance of IoE data base in terms of data depository and access management. Knowledge analytic is the major part of data science; Analytic is a never ending process because of progressive technological change requirements as well as the business change requirements. The beauty of Analytics is that two data scientist with same problem may come up with two different new solutions. So, in this work, I discuss the overall data science and knowledge analytic streams for an effective IoE database management and knowledge discovery.