Gold random microarrays: design, characterization and amperometric determination of ciclopirox olamine in pharmaceutical products

Souza, Ana Paula Ruas de; Felix, Fabiana da Silva; Castro, Pollyana Souza; Angnes, Lúcio; Bertotti, Mauro

doi:10.1039/c5ay03157e

Cited by 9 publications

(2 citation statements)

References 40 publications

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“…Recent publications have also demonstrated the use of LPT to produce tunable hydrophobic valves 17 as well as polyester-toner devices for microdroplets generation 18 and reciprocating mixers. 19 Additional examples regarded to the indirect use of toner for the fabrication of electroanalytical devices, [20][21][22][23][24][25] microchip free-flow electrophoresis, 26 polymer microfluidic devices [27][28][29] and integrated microfluidic cell devices have been also reported. 30 Due to the advantages associated with the fabrication simplicity and low cost per device, some authors have extended the use of LPT to produce toner-based devices for clinical assays involving the use of portable equipment like cell phone camera, scanner, digital camera and handheld optical microscope for colorimetric measurements.…”

Section: Introductionmentioning

confidence: 99%

Colorimetric Detection of Glucose in Biological Fluids Using Toner-Based Microzone Plates

Silva

Oliveira

Coltro

2016

Journal of the Brazilian Chemical Society

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This report describes the use of toner-based microzone plates for quantitative determination of glucose in artificial urine and human serum samples using colorimetric detection. The proposed approach has exhibited a linear response for glucose concentration levels from 0 to 10 mmol L , respectively. The glucose analysis in artificial serum samples revealed error lower than 5% in comparison with certified values provided by the supplier. Lastly, the proposed approach has also provided suitable accuracy (92-105%) for glucose measurements in artificial urine samples. Keywords: bioanalytic, clinical assay, disposable device, point-of-care testing, portable instrumentation IntroductionIn the last years, the miniaturization of analytical systems has received considerable attention due to their attractive advantages including low reagent and sample consumption, portability, minimal waste generation, short time analysis, and high-throughput capability. [1][2][3][4][5][6][7] Standard photolithography is one of the main microfabrication technologies allowing the fabrication of microfluidic channels on different platforms including glass, silicon and quartz. Although this technology provides excellent resolution, it is laborious, expensive and time consuming. 8,9 Furthermore, cleanroom facilities and sophisticated instrumentation are required thereby limiting the access to few research groups. For this reason, simpler, cheaper and faster technologies have been developed to promote the rapid spread of miniaturized analytical systems worldwide. [10][11][12] Among the alternative fabrication methodologies, tonerbased techniques offer simplicity and low instrumental requirements, thus making possible their implementation in any laboratory or research center. 13,14 Toner was firstly explored for microfabrication in 2001, when Tan et al. 15 suggested the use of a photocopying machine to create a high-relief master for prototyping of microfluidic devices in poly(dimetilsyloxane) (PDMS) substrate. In 2003, do Lago et al. 16 proposed the direct fabrication of microfluidic devices using a laser printer for the deposition of toner layers on polyester films followed by a thermal lamination for sealing of channels at low temperature. Since this pioneering report, laser printing technology (LPT) has been used to produce microfluidic toner-based analytical devices (µTADs) at very low cost. Due to the advantages associated with the fabrication simplicity and low cost per device, some authors have extended the use of LPT to produce toner-based devices for clinical assays involving the use of portable equipment like cell phone camera, scanner, digital camera and handheld optical microscope for colorimetric measurements. The association of toner-based devices and colorimetric Colorimetric Detection of Glucose in Biological Fluids Using Toner-Based Microzone Plates J. Braz. Chem. Soc. 198 detection is quite attractive for point-of-care (POC) testing due to operational simplicity and low instrumental requirements. Furthermore, the ment...

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Section: Introductionmentioning

confidence: 99%

Colorimetric Detection of Glucose in Biological Fluids Using Toner-Based Microzone Plates

Silva

Oliveira

Coltro

2016

Journal of the Brazilian Chemical Society

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“…The low cost the disc means they can be, if needed, treated as disposable one shot devices. Further modifications can also be made by techniques such as laser [14] and inkjet printing [12,15,16] or by the heat transfer of toner masks [17][18][19][20][21][22][23] designs onto the metal surface. Other alternative methods for the economic fabrication of electrodes exist and have been widely used and…”

Section: Introductionmentioning

confidence: 99%

Cheap and disposable gold and silver electrodes: Trends in the application of compact discs and digital versatile discs for electroanalytical chemistry

Honeychurch

2017

TrAC Trends in Analytical Chemistry

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Highlights Compact discs and digital versatile discs can be readily used to give cheap reproducible Au and Ag electrodes. Their fabrication and use in electroanalytical chemistry is reviewed. Applications, performance characteristics and construction details are reviewed. AbstractIncreasingly more reports have focused on the use of digital versatile discs (DVDs) and compact discs (CDs) for the fabrication of electrodes. The majority of discs use Al to reflect the laser. However, a notable percentage utilise Au or Ag. This layer can be mechanically or chemically exposed allowing for the economic fabrication of 2 otherwise expensive Ag and Au electrodes. Cleaning steps are not required due to the layer's mirror like surface. Mass production of these discs means they are available, reproducible and disposable. Modifications can be made by laser, inkjet printing, etching or xurography. Self-assembled monolayers and the attachment of functional groups can also be made. This review (98 references and 5 figures) is divided into four sections. The first describes the development of these electrodes and their fabrication and modification. The next three sections focused on applications for the determination of metal ions, biomedical and environmental analysis.

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Direct Toner Printing: A Versatile Technology for Easy Fabrication of Flexible Miniaturized Electrodes

2017

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We reported here three simple, low cost and easy to accomplish strategies for the fabrication of microelectrodes and other conductive patterns using ordinary office laser‐printers. In this work, toner patterns were directly printed onto the flexible substrate, acting as a mask to create the intended conductive design. To highlight the versatility of such technology, toner‐printed patterns were employed in two diverse ways: one in which the patterned toner had the exact design of the electrode and other employing a reverse toner‐printed pattern. The first one was used for the adaptation of the well‐known printed circuit board (PCB) fabrication technique, but using direct toner printing (DTP) in an already conductive flexible substrate. The second was employed for the two remaining strategies: one based on the deposition of conductive film, followed by lift‐off process; and another based on drop‐casting of a conductive ink into the formed toner cavities, followed by thermal cure. As proof‐of‐concept, all three DTP strategies were used for the fabrication of miniaturized gold electrodes in polyimide substrate, and electrochemical performance of each obtained electrode was evaluated by cyclic voltammetry. Insights about DTP technology, alignment issues, advantages, limitations and resolution of each presented approach were provided. Finally, direct toner printing showed to be a simple, affordable and quite promising technology for the fabrication of low cost point‐of‐care electrochemical devices using flexible platforms.

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Gold random microarrays: design, characterization and amperometric determination of ciclopirox olamine in pharmaceutical products

Abstract: In this work, a disposable gold random microarray (GRM) sensor was developed and applied for the determination of ciclopirox olamine in 0.10 mol L−1 Britton Robinson buffer (pH 5.0).

Cited by 9 publications

References 40 publications

Colorimetric Detection of Glucose in Biological Fluids Using Toner-Based Microzone Plates

Colorimetric Detection of Glucose in Biological Fluids Using Toner-Based Microzone Plates

Cheap and disposable gold and silver electrodes: Trends in the application of compact discs and digital versatile discs for electroanalytical chemistry

Direct Toner Printing: A Versatile Technology for Easy Fabrication of Flexible Miniaturized Electrodes

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