Gold–silver-nanoclusters having cholic acid imprinted nanoshell

Gültekin, Aytaç; Ersöz, Arzu; Deni̇zli̇, Adil; Say, Rıdvan

doi:10.1016/j.talanta.2012.02.057

Cited by 19 publications

(13 citation statements)

References 44 publications

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“…The frequency shift for each concentration (0.01-1000 μM) of cholic acid was calculated using the equation ΔF = F 0 -F 1 and the evaluation was performed in triplicate. After each analysis, the desorption process was applied using 2 M sodium hydroxide/ tetrahydrofuran (NaOH/THF) (3:1, v/v) [3]. After desorption step, the cholic acid imprinted QCM nanosensor was washed with deionized water.…”

Section: Monitoring Of the Response Of Cholic Acid Imprinted Qcm Nanomentioning

confidence: 99%

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Development of a highly sensitive MIP based-QCM nanosensor for selective determination of cholic acid level in body fluids

Gültekin

Karanfil

Sönmezoğlu

et al. 2014

Materials Science and Engineering: C

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Determination of cholic acid is very important and necessary in body fluids due to its both pharmaceutical and clinical significance. In this study, a quartz crystal microbalance (QCM) nanosensor, which is imprinted cholic acid, has been developed for the assignation of cholic acid. The cholic acid selective memories have been generated on QCM electrode surface by using molecularly imprinted polymer (MIP) based on methacryloylamidohistidine-copper (II) (MAH-Cu(II)) pre-organized monomer. The cholic acid imprinted nanosensor was characterized by atomic force microscopy (AFM) and then analytical performance of the cholic acid imprinted QCM nanosensor was studied. The detection limit was found to be 0.0065μM with linear range of 0.01-1,000 μM. Moreover, the high value of Langmuir constant (b) (7.3*10(5)) obtained by Langmuir graph showed that the cholic acid imprinted nanosensor had quite strong binding sites affinity. At the last step of this procedure, cholic acid levels in body fluids were determined by the prepared imprinted QCM nanosensor.

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Section: Monitoring Of the Response Of Cholic Acid Imprinted Qcm Nanomentioning

confidence: 99%

“…Hence, the quantification of bile acids in body fluids (such as plasma and urine) is an important tool for the diagnosis of hepatobiliary diseases. Cholic acid as well as its derivatives is a major component of bile acids [3].…”

Section: Introductionmentioning

confidence: 99%

Development of a highly sensitive MIP based-QCM nanosensor for selective determination of cholic acid level in body fluids

Gültekin

Karanfil

Sönmezoğlu

et al. 2014

Materials Science and Engineering: C

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“…The molecularly imprinted polymers (MIPs) are durable and steady synthetic receivers for the analyte of interest. The production of MIPs to perceive specific compounds via quartz crystal microbalance (QCM), which is extremely sensitive to the nanogram level of mass changing weighted down the surface of the QCM electrode, has been achieved in recent years [21][22][23][24][25][26] and the procedure is rapid, low cost, easy to use, highly specific and selective.…”

Section: Introductionmentioning

confidence: 99%

Gadolinium chelate monomer based memories onto QCM electrodes for folic acid detection in commercial follow-on baby milk

2018

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A novel folic acid-imprinted quartz crystal microbalance (QCM) nanosensor in order to detect folic acid depending on the fabrication of folic acid-imprinted polymer film on a QCM electrode was developed with methacrylamidoantipyrine-gadolinium (III) [MAAP-Gd(III)] used as a monomer for metal coordination-chelation interaction to obtain a more selective molecularly imprinted polymers (MIPs). The developed folic acid-imprinted nanosensor on the MIP/QCM detection system showed outstanding properties such as a stronger affinity of 3.07 × 10 7 M −1 , a short response time of 10 min, wider linear range of 0-100 µM, a selectivity of k = 8.25 and lower detection limit of 0.0080 µM. After characterizing its all features, the newly designed folic acid-imprinted QCM nanosensor was utilized to detect folic acid level in commercial follow-on baby milk in order to determine its use in real samples.

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“…[1,2] Usually in clinic, evaluation of bile acids concentration in body has been employed to diagnose hepatitis, gallstone and other diseases in liver. [4,5] Therefore, it is very important for the determination of bile acids in body fluids (such as serum and urine) for the diagnosis of hepatobiliary diseases. However, in hepatobiliary and intestinal diseases, because the hepatic synthesis and clearance of bile acids and their intestinal absorption are disturbed, the concentration of bile acids is elevated by two or three fold for individuals.…”

Section: Introductionmentioning

confidence: 99%

A Simple and Novel Electrochemical Sensor Based on Phosphomolybdic‐Polypyrrole Film Modified Electrode for Highly Sensitive Detection of Cholic Acid

et al. 2016

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A simpe electrochemical sensor for detection of cholic acid (CA) was designed by modifying phosphomolybdate (PMo 12 ) doped polypyrrole (PPy) film on glassy carbon electrode (PMo 12 -PPy/GCE). The electrochemical behavior of CA on PMo 12 -PPy/GCE was investigated by cyclic voltammetry and 0.5 order differential voltammetry. The results indicated that CA had high inhibitory activity toward the peak currents of PMo 12 -PPy/GCE. The reduction peak currents were linearly related to the logarithmic value of the concentration of CA from 1.0×10 7 to 1.0× 10 3 mol/L with a low detection limit of 1.0×10 8 mol/L. The developed sensor exhibited excellent sensitivity, selectivity and stability for detection of CA, and it could be successfully applied to detect the level of CA in the urine samples. Moreover, the response mechanism of CA on the PMo 12 -PPy/GCE was discussed in detail.

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Gold–silver-nanoclusters having cholic acid imprinted nanoshell

Cited by 19 publications

References 44 publications

Development of a highly sensitive MIP based-QCM nanosensor for selective determination of cholic acid level in body fluids

Development of a highly sensitive MIP based-QCM nanosensor for selective determination of cholic acid level in body fluids

Gadolinium chelate monomer based memories onto QCM electrodes for folic acid detection in commercial follow-on baby milk

A Simple and Novel Electrochemical Sensor Based on Phosphomolybdic‐Polypyrrole Film Modified Electrode for Highly Sensitive Detection of Cholic Acid

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