‘Golden’ exosomes as delivery vehicles to target tumors and overcome intratumoral barriers: <i>in vivo</i> tracking in a model for head and neck cancer

Cohen, Oded; Betzer, Oshra; Elmaliach-Pnini, Noy; Motiei, Menachem; Sadan, Tamar; Cohen-Berkman, Moran; Dagan, Or; Popovtzer, Aron; Yosepovich, Ady; Barhom, Hana; Michaeli, Shulamit; Popovtzer, Rachela

doi:10.1039/d0bm01735c

Cited by 39 publications

(37 citation statements)

References 63 publications

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“…The results clearly showed that the distribution of MSC-EXOs in the brain was closely related to inflammation [59]. Betzer et al [60] and Cohen et al [56] also used similar methods to evaluate the biodistribution of MSC-EXOs in the body. By studying the tracing of MSC-EXOs in the body, we can better research biodistribution, pharmacodynamics, targeting, etc.…”

Section: Evaluation Of Targeting Efficacymentioning

confidence: 98%

“…Although researchers have conducted many experiments on MSC-EXOs, there is a lack of research on tracking and biodistribution in vivo [55]. At present, the primary methods for labeling MSC-EXOs in organisms are as follows: One is to wrap metal nanoparticles in exosomes, perform high-sensitivity magnetic resonance or CT analysis [52,56], use radioactive tracers and nuclear imaging for tracking [57], and stained with fluorescent dyes [58]. Perets et al developed a new visualization method that loaded glucose-coated GNPs (gold nanoparticles) into MSC-EXOs and used classical X-ray computed tomography (CT) to perform imaging to evaluate the biodistribution of MSC-EXOs in different pathological types of brain.…”

Section: Evaluation Of Targeting Efficacymentioning

confidence: 99%

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Mesenchymal stem cells-derived exosomes for drug delivery

et al. 2021

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Exosomes are extracellular vesicles secreted by various cells, mainly composed of lipid bilayers without organelles. In recent years, an increasing number of researchers have focused on the use of exosomes for drug delivery. Targeted drug delivery in the body is a promising method for treating many refractory diseases such as tumors and Alzheimer's disease (AD). Finding a suitable drug delivery carrier in the body has become a popular research today. In various drug delivery studies, the exosomes secreted by mesenchymal stem cells (MSC-EXOs) have been broadly researched due to their immune properties, tumor-homing properties, and elastic properties. While MSC-EXOs have apparent advantages, some unresolved problems also exist. This article reviews the studies on MSC-EXOs for drug delivery, summarizes the characteristics of MSC-EXOs, and introduces the primary production and purification methods and drug loading methods to provide solutions for existing problems and suggestions for future studies.

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Section: Evaluation Of Targeting Efficacymentioning

confidence: 98%

Section: Evaluation Of Targeting Efficacymentioning

confidence: 99%

Mesenchymal stem cells-derived exosomes for drug delivery

et al. 2021

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“…The exosomes were discovered to be capable of targeting and accumulating at the tumor site for CT imaging. Therefore, GNPs combined with exosomes have great potential in clinical applications ( 111 ).…”

Section: Gold Nanoparticles Combined With Biomoleculesmentioning

confidence: 99%

The Applications of Gold Nanoparticles in the Diagnosis and Treatment of Gastrointestinal Cancer

et al. 2022

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In recent years, the morbidity and mortality of gastrointestinal cancer have remained high in China. Due to the deep location of the gastrointestinal organs, such as gastric cancer, the early symptoms of cancer are not obvious. It is generally discovered at an advanced stage with distant metastasis and lymph node infiltration, making it difficult to cure. Therefore, there is a significant need for novel technologies that can effectively diagnose and treat gastrointestinal cancer, ultimately reducing its mortality. Gold nanoparticles (GNPs), a type of nanocarrier with unique optical properties and remarkable biocompatibility, have the potential to influence the fate of cancer by delivering drugs, nucleic acids to cancer cells and tissues. As a safe and reliable visualization agent, GNPs can track drugs and accurately indicate the location and boundaries of cancer, opening up new possibilities for cancer treatment. In addition, GNPs have been used in photodynamic therapy to deliver photosensitizers, as well as in combination with photothermal therapy. Therefore, GNPs can be used as a safe and effective nanomaterial in the treatment and diagnosis of gastrointestinal cancer.

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“…Given their limited bioavailability, however, synthetic exosome-mimics have been used in their place to mediate endogenous and exogenous delivery for cancer treatment [ 12 ]. In particular, Cohen et al evaluated the parameters of exosomes derived from mesenchymal stem cells (MSC-exo) and A431 squamous cell carcinoma cells (A431-exo) as drug vectors and found MSC-exo to exhibit significantly greater tumor penetration and distribution in A431 tumor-bearing mice [ 38 ]. These results underscore that careful consideration should be given to an exosome’s type when applying it to drug delivery due to its unique properties and inherent targeting capabilities.…”

Section: Role Of Exosomes In the Diagnosis And Treatment Of Hnsccmentioning

confidence: 99%

The Hidden Link of Exosomes to Head and Neck Cancer

Teng

Gao

Loveless

et al. 2021

Cancers

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Head and neck squamous cell carcinoma (HNSCC) represents an aggressive and heterogenous group of cancers whose pathologies remain largely unresolved. Despite recent advances in HNSCC therapeutic strategies, the overall survival of HNSCC patients remains poor and continues to prompt efforts to develop more effective therapies. Exosomes are a subtype of extracellular vesicles secreted by a variety of cells that have begun to spark significant interest in their roles in cancer. As membranous vesicles, spanning from 30–150 nm in diameter, exosomes mediate the transport of various molecules, such as proteins, nucleic acids, and lipids, intercellularly throughout the body. In doing so, exosomes not only act to deliver materials to cancer cells but also as signals that can confer their progression. Accumulating evidence shows the direct correlation between exosomes and the aggressiveness of HNSCC. However, more research is warranted in this field to further our understanding. In this review, we attempt to highlight the tumor-supporting roles and therapeutic potential of exosomes in HNSCC. We introduce first the biogenesis and component features of exosomes, followed by their involvement in HNSCC proliferation and metastasis. We then move on to discuss HNSCC-derived exosomes’ influence on the tumor microenvironment and their function in tumor drug resistance. Finally, we explore the promising potential of exosomes as HNSCC biomarkers and therapeutic targets and drug carriers for HNSCC treatments.

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‘Golden’ exosomes as delivery vehicles to target tumors and overcome intratumoral barriers: in vivo tracking in a model for head and neck cancer

Abstract: Exosomes are promising vectors for anti-tumor therapy. In this research, both in-vivo CT tracking and ex-vivo measurements revealed better tumor targeting, accumulation and penetration of MSC-derived exosomes as compared to A431-derived exosomes.

Cited by 39 publications

References 63 publications

Mesenchymal stem cells-derived exosomes for drug delivery

Mesenchymal stem cells-derived exosomes for drug delivery

The Applications of Gold Nanoparticles in the Diagnosis and Treatment of Gastrointestinal Cancer

The Hidden Link of Exosomes to Head and Neck Cancer

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