Golden Opportunities: Plasmonic Gold Nanostructures for Biomedical Applications based on the Second Near‐Infrared Window

Park, Jeong-Eun; Kim, Minho; Hwang, Jae‐Ho; Nam, Jwa‐Min

doi:10.1002/smtd.201600032

Cited by 113 publications

(77 citation statements)

References 81 publications

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“…Since light absorption and scattering are less for biological samples, particularly for in vivo environment, with NIR-II window than with NIR-I window, [41,70] the NIR-II window requires very low external light intensity, which is far below the skin tolerance threshold set by the American National Standards Institute (ANSI), and allows for deep skin penetration possible, making the NIR-II window more suitable for in vivo applications. Since light absorption and scattering are less for biological samples, particularly for in vivo environment, with NIR-II window than with NIR-I window, [41,70] the NIR-II window requires very low external light intensity, which is far below the skin tolerance threshold set by the American National Standards Institute (ANSI), and allows for deep skin penetration possible, making the NIR-II window more suitable for in vivo applications.…”

Section: Plasmonic Photothermal Metallic Nanoparticlesmentioning

confidence: 99%

Plasmonic Photothermal Nanoparticles for Biomedical Applications

2019

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Recent advances of plasmonic nanoparticles include fascinating developments in the fields of energy, catalyst chemistry, optics, biotechnology, and medicine. The plasmonic photothermal properties of metallic nanoparticles are of enormous interest in biomedical fields because of their strong and tunable optical response and the capability to manipulate the photothermal effect by an external light source. To date, most biomedical applications using photothermal nanoparticles have focused on photothermal therapy; however, to fully realize the potential of these particles for clinical and other applications, the fundamental properties of photothermal nanoparticles need to be better understood and controlled, and the photothermal effect‐based diagnosis, treatment, and theranostics should be thoroughly explored. This Progress Report summarizes recent advances in the understanding and applications of plasmonic photothermal nanoparticles, particularly for sensing, imaging, therapy, and drug delivery, and discusses the future directions of these fields.

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Section: Plasmonic Photothermal Metallic Nanoparticlesmentioning

confidence: 99%

Plasmonic Photothermal Nanoparticles for Biomedical Applications

2019

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“…Moreover, the sizes and shapes of nanostructures can affect the distribution of free electrons, thus influence the shape of the extinction spectra . By altering the structure of the surface, the optical properties of nanosubstrates can be tailored and offer the potential for developing biosensors working in different light windows . Thus, the reasonable design of nanostructures comes first for building a LSPR sensor …”

Section: Principle and Fabrication Of Lspr Biosensorsmentioning

confidence: 99%

“…LSPR nanostructures can be classified into two categories: colloids and solid substrates. Typical nanostructures in colloids include nanospheres, nanorods, and nanoprisms . Up till now, the highest RI sensitivity of colloidal nanostructures is 1091 nm per RIU, which was realized by a left‐handed 128 nm tall helix composed of 97% Ag and 3% Ti .…”

Section: Principle and Fabrication Of Lspr Biosensorsmentioning

confidence: 99%

Construction of Plasmonic Nano‐Biosensor‐Based Devices for Point‐of‐Care Testing

Wang

Zhou

2017

Small Methods

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rapid detection technique for the future of home healthcare, mobile healthcare, and public health security. [4] At present, POCTs mainly use conventional lateral flow assays (LFAs) and electrochemical biosensors (such as blood glucose meter) for biosensing. [4,5] To promote the wider application of POCT, new sensing components are expected to appear. Plasmonic nano-biosensor, which stems from the interaction of light and metal nanostructures, is an advancing and promising optical sensor for ultrasensitive, ultrahighspatial-resolution and label-free biodetection. Plasmonic biosensors are mainly divided into propagating surface plasmon resonance (PSPR) and localized surface plasmon resonance (LSPR) biosensors. PSPR arises from the interaction between incident light and a planar metal surface; LSPR confines light to metal nanostructures that are smaller than the wavelength of light, thereby enabling the measurement of the dielectric changes near the metallic surface. [6] Compared with commercially available PSPR sensors, LSPR sensors are simple, cost effective, easy to integrate into miniaturized devices, and suitable for measuring changes in local refractive index (RI) caused by the adsorption of target molecules. [4] Since RI is related to the dielectric property of the environment near the metal nanostructures, LSPR sensors can realize RI biosensing in a convenient way. LSPR nano-biosensors are expected to be easily integrated into miniaturized devices for POCT. Due to the high sensitivity of LSPR biosensor and its possibility to achieve full automation, as therefore to attain time-saving and avoid human error, the integration of LSPR biosensors into portable devices will promote the wider applications of POCT for enhanced healthcare (e.g., on-site diagnosis, personalized medicine, wearable devices, etc.), higher public security (e.g., antiterrorism), environmental monitoring, and food safety. [7][8][9] The evolving of LSPR biosensing into POCT mainly involves four core requirements (Figure 1): i) sensing nanosubstrates with high RI sensitivity; ii) detection strategies to realize specific detection; iii) integrated microfluidic chips for sample pretreatment and multiplex analysis, and iv) portable POCT devices to perform automated and easy-to-use biodetections. Through the advances on plasmonics and nanofabrication in the last few years, highly sensitive as well as large-area producible nanosubstrates for LSPR biosensing have been developed. [10][11][12] In the meanwhile, high specificity and strong anti-interference Next-generation healthcare equipment and devices are in great demand for point-of-care testing (POCT), in view of their applications in rapid disease diagnosis, personalized medicine, portable or mobile health care, nontechnician assays, etc. Localized surface plasmon resonance (LSPR) biosensors, which are based on noble-metal nanostructures and which provide fast, realtime, nonlabeled, and sensitive biochemical detections, have become one of the leading candidates for POCT. The advances in nanofabr...

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“…[16][17][18][19][20][21][22][23][24][25][26][27] However, only seldom types can actually be tuned to possess strong absorption in the NIR-II window under limited conditions because the sizes, shapes, and structures (solid and hollow) of AuNPs are closely related to their plasmonic absorption peak. [28] For example, traditional Au nanorods need to reach an aspect ratio of 6 or more, [29] the spike AuNPs need their needles very long, [30] and Au nanoshells require a large external diameter and a thin wall thickness. [15] Although adjusting these types is feasible to acquire NIR-II-window-responsive AuNPs, final sizes of their hydrates are usually over 100 nm, [10] which is a critical size limit for the particles penetration in tumor.…”

Section: Introductionmentioning

confidence: 99%

Miniature Hollow Gold Nanorods with Enhanced Effect for In Vivo Photoacoustic Imaging in the NIR‐II Window

Cai

Zhang

Foda

et al. 2020

Small

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The miniaturization of gold nanorods exhibits a bright prospect for intravital photoacoustic imaging (PAI) and the hollow structure possesses a better plasmonic property. Herein, miniature hollow gold nanorods (M‐AuHNRs) (≈46 nm in length) possessing strong plasmonic absorbance in the second near‐infrared (NIR‐II) window (1000–1350 nm) are developed, which are considered as the most suitable range for the intravital PAI. The as‐prepared M‐AuHNRs exhibit 3.5 times stronger photoacoustic signal intensity than the large hollow Au nanorods (≈105 nm in length) at 0.2 optical density under 1064 nm laser irradiation. The in vivo biodistribution measurement shows that the accumulation in tumor of miniature nanorods is twofold as high as that of the large counterpart. After modifying with a tumor‐targeting molecule and fluorochrome, in living tumor‐bearing mice, the M‐AuHNRs group gives a high fluorescence intensity in tumors, which is 3.6‐fold that of the large ones with the same functionalization. Moreover, in the intravital PAI of living tumor‐bearing mice, the M‐AuHNRs generate longer‐lasting and stronger photoacoustic signal than the large counterpart in the NIR‐II window. Overall, this study presents the fabrication of M‐AuHNRs as a promising contrast agent for intravital PAI.

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Golden Opportunities: Plasmonic Gold Nanostructures for Biomedical Applications based on the Second Near‐Infrared Window

Cited by 113 publications

References 81 publications

Plasmonic Photothermal Nanoparticles for Biomedical Applications

Plasmonic Photothermal Nanoparticles for Biomedical Applications

Construction of Plasmonic Nano‐Biosensor‐Based Devices for Point‐of‐Care Testing

Miniature Hollow Gold Nanorods with Enhanced Effect for In Vivo Photoacoustic Imaging in the NIR‐II Window

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