Goldfish brain and heart are well protected from Ni2+-induced oxidative stress

Low salinity enhances NI-mediated oxidative stress and sub-lethal toxicity to the green shore crab (Carcinus maenas)

“…Ni has been shown to cause oxidative stress in freshwater fish (Kubrak et al, 2012a(Kubrak et al, ,b, 2013(Kubrak et al, , 2014Loro et al, 2012), and metals are known to also cause oxidative stress in marine invertebrates (Sabatini et al, 2009;Vlahogianni et al, 2007). The present data are the first to show oxidative stress in response to Ni in marine invertebrates.…”

“…Secondly, Ni can affect antioxidant responses yielding a lower defence against ROS production. The current findings suggest that oxidative stress is a common conserved mechanism of Ni toxicity in aquatic animals, having previously been observed in fish Kubrak et al, 2012aKubrak et al, ,b, 2013Kubrak et al, , 2014.…”

“…Ni may also have an effect on antioxidant mechanisms, thereby decreasing the cell's ability to scavenge reactive oxygen species (ROS), and leading to increased ROS-related damage. In the freshwater environment the relationship between Ni and oxidative stress has been investigated mainly in goldfish, Carassius auratus (Kubrak et al, 2012a(Kubrak et al, ,b, 2013(Kubrak et al, , 2014. Ni has also been shown to affect antioxidant enzymes in both freshwater-and seawater-acclimated killifish, Fundulus heteroclitus while other metals (Cu, Zn) have been shown to induce oxidative stress in both freshwater and estuarine fish (e.g.…”

Combined effects of temperature changes and metal contamination at different levels of biological organization in yellow perch

“…The addition of Ni contamination to thermal stress induces an increase of SOD activity (Banni et al, 2014), reflecting an increase of oxidative stress induced by temperature (Bagnyukova et al, 2007) and metal accumulation (Cao et al, 2012;Kubrak et al, 2014).…”

Novel Route of Toxicant Exposure in an Ancient Extant Vertebrate: Nickel Uptake by Hagfish Skin and the Modifying Effects of Slime

“…The accumulation of nickel in the heart and brain of Pacific hagfish was a more surprising finding. In teleost fish, nickel accumulates preferentially in plasma, bone, gills, and kidney, and accumulation is mostly a consequence of plasma trapping. , For example, there was no accumulation in the brain of fish exposed to waterborne nickel (e.g., goldfish; round goby and rainbow trout). Conversely, Alsop and colleagues, showed that the zebrafish brain increased nickel accumulation by more than 40% following an 80 day dietary exposure to 116 μg g –1 nickel.…”