Gonadal development and sex determination in mouse

Yildirim, Ecem; Aksoy, Sena Dilek; Onel, Tugce; Yaba, Aylin

doi:10.1016/j.repbio.2020.01.007

Cited by 22 publications

(24 citation statements)

References 178 publications

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“…During the various stages of spermatogenesis, apoptosis frequently occurs though its beneficial/detrimental consequences are reported (Shukla et al, 2012). The development of primordial germ cells and gonads is determinants of reproductive health and fertility (Yildirim et al, 2020), and it was reported that the growth and development of testicular tissue are critical to maintaining its functions (Vizcarra et al, 2010). It seems that apoptosis inhibition is a logical strategy to achieve such development.…”

Section: Introductionmentioning

confidence: 99%

Dietary L‐carnitine affects the expression of genes involved in apoptosis and fatty acid metabolism in rooster testes

et al. 2020

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Thirty‐six 12‐week‐old breeder roosters (Ross 308) were randomly allocated into three groups to receive L‐carnitine (LC): LC‐0, LC‐250 or LC‐500 mg/kg of diet to evaluate the effects of dietary LC on the expression of apoptotic‐related genes and desaturases and elongase mRNA transcript levels, in the cockerel testicles. Alteration of Bak (Bcl2 antagonist/killer), Bcl2, Cas3, Cas8, Cas9, Elovl2, Elovl4, Elovl5, Fads1, Fads2 and Scd expression at 24 and 34 weeks of age was compared by real‐time quantitative PCR. The expression of Bcl2 and Elovl5 was significantly up‐regulated (p < .05), while Cas8 expression (p < .05) and Bak/Bcl2 ratio were reduced (p < .02) in the cockerel testicles at 24 weeks of age. Although Bak mRNA abundance decreased by dietary LC, Bak/Bcl2 ratio was not affected by the treatments at 34 weeks of age. The expression of Cas3 was down‐regulated, while Fads2 was up‐regulated in the cockerel testicles by dietary LC at 34 weeks of age (p < .05). The results demonstrate the beneficial effects of LC supplementation in suppression of the Bak/Bcl2 ratio by altering Bak and Bcl2 mRNA abundance and, ultimately, prevention of apoptosis. Furthermore, LC increased the expression of Elovl5 and Fads2 genes which are involved in the metabolism of long chain fatty acids.

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Section: Introductionmentioning

confidence: 99%

Dietary L‐carnitine affects the expression of genes involved in apoptosis and fatty acid metabolism in rooster testes

et al. 2020

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“…Células madre espermatogoniales (SSC) / células madre oogoniales (OSC) 3. Espermatocito / ovocito [11].…”

Section: Células Germinales En El Ratónunclassified

“…Los espermatocitos pasan al compartimento adluminal al comienzo de la fase preleptoteno de la meiosis y atraviesan BTB. La célula de Sertoli proporciona lo necesario para que las células germinales maduren [11].…”

Section: Células Germinales En El Ratónunclassified

“…En la etapa indiferente o bipotencial las características de desarrollo del sistema reproductor femenino y masculino son iguales. En este periodo, el embrión tiene conductos tanto de Wolff como de Müller, que posteriormente se convierten en las estructuras que determinan las características sexuales [11].…”

Section: Desarrollo Y Diferenciación Sexual En Los Testículos De Ratónunclassified

“…La diferenciación morfológica del canal de Wolff ocurre en el E15 en ratones [29,30]. En hembras, en ausencia de hormonas testiculares y MIS los conductos de Wolff retroceden (entre los días embrionarios E14.5 y E16.5) mientras que los conductos de Müller se mantienen [11].…”

Section: Desarrollo Y Diferenciación Sexual En Los Testículos De Ratónunclassified

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Exposición a sulfonato de perfluorooctano (PFOS) durante el desarrollo gonadal temprano y sus efectos en la diferenciación testicular en ratones adultos CD-1

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Intergenerational effects on fertility in male and female mice after chronic exposure to environmental doses of NSAIDs and 17α-ethinylestradiol mixtures

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Gonadal development and sex determination in mouse

Cited by 22 publications

References 178 publications

Dietary L‐carnitine affects the expression of genes involved in apoptosis and fatty acid metabolism in rooster testes

Dietary L‐carnitine affects the expression of genes involved in apoptosis and fatty acid metabolism in rooster testes

Exposición a sulfonato de perfluorooctano (PFOS) durante el desarrollo gonadal temprano y sus efectos en la diferenciación testicular en ratones adultos CD-1

Intergenerational effects on fertility in male and female mice after chronic exposure to environmental doses of NSAIDs and 17α-ethinylestradiol mixtures

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