Gonadal Glands and Their Gene Products

Wolfner, Mariana F.

doi:10.1016/b0-44-451924-6/00014-4

Cited by 35 publications

(39 citation statements)

References 287 publications

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“…Ectopic expression of individual Acps in virgin females did not affect receptivity to mating or egglaying rate: The postmating increase in egg laying and decrease in receptivity are also regulated by Acps (reviewed in Wolfner et al 2005). To test the 22 Acps for roles in these processes, we compared the receptivity to mating and the egg-laying rates of virgin females Figure 3.-Toxicity of 22 individual Acps when constitutively expressed in preadults.…”

Section: Resultsmentioning

confidence: 99%

“…Approximately 70-106 seminal fluid accessory gland proteins (Acps) are produced in the male's accessory gland. Acps increase the egg-laying rate of mated females, decrease their receptivity to remating, induce them to store sperm, induce them to eat (Carvalho et al 2006), and decrease their life span (reviewed in Kubli 2003;Chapman and Davies 2004;Wolfner et al 2005). Acps also have the potential to provide immune-related functions to females: Acps upregulate antimicrobial gene transcript levels in mated females (McGraw et al 2004;Peng et al 2005), and at least three Acps have antimicrobial activity in vitro (Lung et al 2001).…”

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confidence: 99%

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An Ectopic Expression Screen Reveals the Protective and Toxic Effects of Drosophila Seminal Fluid Proteins

Mueller¹,

2007

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In Drosophila melanogaster, seminal fluid regulates the reproductive and immune responses of mated females. Some seminal fluid proteins may provide protective functions to mated females, such as antimicrobial activity and/or stimulation of antimicrobial gene expression levels, while others appear to have negative effects, contributing to a ''cost of mating.'' To identify seminal proteins that could participate in these phenomena, we used a systemic ectopic expression screen to test the effects on unmated females of proteins normally produced by the male accessory gland (Acps). Of the 21 ectopically expressed Acps that we tested for ability to assist in the clearance of a bacterial infection with Serratia marcescens, 3 Acps significantly reduced the bacterial counts of infected females, suggesting a protective role. Of the 23 Acps that we tested for toxicity, 3 were toxic, including one that has been implicated in the cost of mating in another study. We also tested ectopic expression females for other Acp-induced effects, but found no additional Acps that affected egg laying or receptivity upon ectopic expression.

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Section: Resultsmentioning

confidence: 99%

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confidence: 99%

An Ectopic Expression Screen Reveals the Protective and Toxic Effects of Drosophila Seminal Fluid Proteins

Mueller¹,

2007

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“…aegypti have been attributed to the effect of specific mRGPs in another Diptera species, Drosophila melanogaster (reviewed in Wolfner, 2002;Gillott, 2003;Chapman and Davies, 2004;Wolfner et al, 2005;Wong et al, 2006;. These proteins include: (1) simple peptides, including a "sex peptide" (Acp70A) that induces sexual refractoriness, increases the rate of egg production, and changes the feeding behavior and longevity of female Drosophila (Chapman et al, 2003;Liu and Kubli, 2003;Wigby and Chapman, 2005;Carvalho et al, 2006); (2) "prohormone-like" peptides, one of which (ovulin/Acp26Aa) stimulates ovulation (Heifetz et al, 2000); (3) large glycoproteins which are important for sperm storage (Neubaum and Wolfner, 1999) and other sperm-binding proteins; and (4) proteolysis regulators (Mueller et al, 2004;Ravi Ram et al, 2006;Mueller et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Identity and transfer of male reproductive gland proteins of the dengue vector mosquito, Aedes aegypti: Potential tools for control of female feeding and reproduction

Sirot

Poulson

McKenna

et al. 2008

Insect Biochemistry and Molecular Biology

155

166

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Male reproductive gland proteins (mRGPs) impact the physiology and/or behavior of mated females in a broad range of organisms. We sought to identify mRGPs of the yellow fever mosquito, Aedes aegypti, the primary vector of dengue and yellow fever viruses. Earlier studies with Ae. aegypti demonstrated that "matrone" (a partially purified male reproductive accessory gland substance) or male accessory gland fluid injected into virgin female Ae. aegypti affect female sexual refractoriness, blood feeding and digestion, flight, ovarian development, and oviposition. Using bioinformatic comparisons to Drosophila melanogaster accessory gland proteins and mass spectrometry of proteins from Ae. aegypti male accessory glands and ejaculatory ducts (AG/ED) and female reproductive tracts, we identified 63 new putative Ae. aegypti mRGPs. Twenty-one of these proteins were found in the reproductive tract of mated females, but not of virgin females, suggesting that they are transferred from males to females during mating. Most of the putative mRGPs fall into the same protein classes as mRGPs in other organisms, although some appear to be evolving rapidly and lack identifiable homologs in Culex pipiens, Anopheles gambiae, and D. melanogaster. Our results identify candidate male-derived molecules that may have an important influence on behavior, survival and reproduction of female mosquitoes.

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“…Genes encoding proteins secreted by male accessory glands (Acps), ejaculatory duct, and ejaculatory bulb and all major components of D. melanogaster seminal fluid (hereafter referred to collectively as seminal fluid proteins or SFPs). These proteins are particularly interesting because they are transferred from the male to the female along with sperm during mating and mediate a number of postmating events (for reviews, see Kubli 2003;Chapman and Davies 2004;Wolfner et al 2005;Wong and Wolfner 2006;Ravi Ram and Wolfner 2007). From an evolutionary perspective, evidence for adaptive evolution has been found at several loci encoding D. melanogaster SFPs (Aguadé et al 1992;Tsaur and Wu 1997;Aguadé 1999;Begun et al 2000;Swanson et al 2001;Mueller et al 2005).…”

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confidence: 99%

Evolution in the Fast Lane: Rapidly Evolving Sex-Related Genes in Drosophila

et al. 2007

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A large portion of the annotated genes in Drosophila melanogaster show sex-biased expression, indicating that sex and reproduction-related genes (SRR genes) represent an appreciable component of the genome. Previous studies, in which subsets of genes were compared among few Drosophila species, have found that SRR genes exhibit unusual evolutionary patterns. Here, we have used the newly released genome sequences from 12 Drosophila species, coupled to a larger set of SRR genes, to comprehensively test the generality of these patterns. Among 2505 SRR genes examined, including ESTs with biased expression in reproductive tissues and genes characterized as involved in gametogenesis, we find that a relatively high proportion of SRR genes have experienced accelerated divergence throughout the genus Drosophila. Several testis-specific genes, male seminal fluid proteins (SFPs), and spermatogenesis genes show lineage-specific bursts of accelerated evolution and positive selection. SFP genes also show evidence of lineage-specific gene loss and/ or gain. These results bring us closer to understanding the details of the evolutionary dynamics of SRR genes with respect to species divergence.

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Gonadal Glands and Their Gene Products

Cited by 35 publications

References 287 publications

An Ectopic Expression Screen Reveals the Protective and Toxic Effects of Drosophila Seminal Fluid Proteins

An Ectopic Expression Screen Reveals the Protective and Toxic Effects of Drosophila Seminal Fluid Proteins

Identity and transfer of male reproductive gland proteins of the dengue vector mosquito, Aedes aegypti: Potential tools for control of female feeding and reproduction

Evolution in the Fast Lane: Rapidly Evolving Sex-Related Genes in Drosophila

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