Gonado-histopathological changes, intersex and endocrine disruptor responses in relation to contaminant burden in Tilapia species from Ogun River, Nigeria

Ibor, Oju R.; Adeogun, Aina O.; Fagbohun, Olusegun; Arukwe, Augustine

doi:10.1016/j.chemosphere.2016.08.087

Cited by 29 publications

(6 citation statements)

References 55 publications

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“…Although most of these compounds are present at low concentrations (μg/L to pg/L), many of them raise considerable toxicological concerns, with largely unknown long-term effects on aquatic life and on human health. For instance, many studies showed that contaminations of rivers with estrogenic and androgenic compounds in the ng/L range, are responsible for intersex changes within fish populations [3,4] raising concerns about population-level consequences [5]. In Brazil, a study conducted in 2710 newborn males revealed fetal contamination with organochlorine pesticides (DDT) with a risk factor for external genital malformations [6], whereas in young girls, fetal and/or environmental exposure to endocrine disrupting chemicals (EDCs) led to precocious puberty [7,8].…”

Section: Introductionmentioning

confidence: 99%

Neurotoxicity of a Biopesticide Analog on Zebrafish Larvae at Nanomolar Concentrations

Nasri

Valverde

Roche

et al. 2016

IJMS

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Despite the ever-increasing role of pesticides in modern agriculture, their deleterious effects are still underexplored. Here we examine the effect of A6, a pesticide derived from the naturally-occurring α-terthienyl, and structurally related to the endocrine disrupting pesticides anilinopyrimidines, on living zebrafish larvae. We show that both A6 and an anilinopyrimidine, cyprodinyl, decrease larval survival and affect central neurons at micromolar concentrations. Focusing on a superficial and easily observable sensory system, the lateral line system, we found that defects in axonal and sensory cell regeneration can be observed at much lower doses, in the nanomolar range. We also show that A6 accumulates preferentially in lateral line neurons and hair cells. We examined whether A6 affects the expression of putative target genes, and found that genes involved in apoptosis/cell proliferation are down-regulated, as well as genes reflecting estrogen receptor activation, consistent with previous reports that anilinopyrimidines act as endocrine disruptors. On the other hand, canonical targets of endocrine signaling are not affected, suggesting that the neurotoxic effect of A6 may be due to the binding of this compound to a recently identified, neuron-specific estrogen receptor.

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Section: Introductionmentioning

confidence: 99%

Neurotoxicity of a Biopesticide Analog on Zebrafish Larvae at Nanomolar Concentrations

Nasri

Valverde

Roche

et al. 2016

IJMS

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“…For example, in the Ogun River, Nigeria, 15 PCB congeners, lindane, dieldrin, 4-isononylphenol and 4-tert-octylphenol analysed in fish muscle and sediments samples have been associated with 24% prevalence of intersex. This correlated with gonadal histopathological changes, significantly higher plasma estradiol-17ꞵ, luteinizing hormone, follicle stimulating hormones as well as hepatic transcript levels of Vtg, zona radiata and aromatase in male fish (Ibor et al, 2016).…”

Section: Endocrine-disrupting Chemicals (Edcs)mentioning

confidence: 68%

Biomonitoring of aquatic pollution: status and trends from genomics to populations

Adeyemo

Sogbanmu

Selim

et al. 2020

PNgAS

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Biomonitoring offers an appealing tool for the assessment of pollution in aquatic ecosystem. Biological processes, species, or communities of bioindicators are used to assess the quality of the environment and how it changes over time. Bioindicators include algae, macrophytes, zooplanktons, insects, bivalves, molluscs, gastropods, fish, amphibians, and others. Changes in aquatic ecosystems are often attributed to anthropogenic disturbances, including pollution. Major contributors to aquatic pollution include wastewater, metals and metalloids, industrial effluents, contaminated sediments, nutrients, polycyclic aromatic hydrocarbons, flame retardants, persistent organic pollutants, pharmaceuticals and illicit drugs, emerging contaminants (such as microplastics and engineered nanoparticles), pesticides, herbicides, and endocrine disruptors. In this review, we discuss categories of aquatic pollutants, status and trends of aquatic biomonitoring and approaches, from genomics to populations. We conclude by offering recommendations for research and regulatory testing.

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“…Ibor et al, 2016 [ 58 ], analyzed PCB concentrations in muscle tissue of tilapia species ( Tilapia guineensis , Sarotherodon galileaus and Oreochromis niloticus ) from four sites along the Ogun River. Significantly higher PCB concentrations were found in fish from the three polluted sites compared to the control site, with sum PCB (15 congeners) varying between 359–4636 μg/kg and 24–28 μg/kg, respectively.…”

Section: Resultsmentioning

confidence: 99%

A Review of Chemical Contaminants in Marine and Fresh Water Fish in Nigeria

Uzomah

Lundebye

Kjellevold

et al. 2021

Foods

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Pollutants in aquatic food are a major global concern for food safety and are a challenge to both national and international regulatory bodies. In the present work, we have reviewed available data on the concentrations of polycyclic aromatic hydrocarbons (PAH), persistent organic pollutants, metals, and microplastics in freshwater and marine fish in Nigeria with reference to international maximum levels for contaminants in food and the potential risk to human health. While most of the contaminant levels reported for fish do not imply any health issues, iron and lead may represent potentially toxic levels in fish from specific areas. Studies on PAHs in marine fish are scarce in Nigeria, and the main focus is on the environmental pollution caused by PAHs rather than on their presence in food. The findings suggest that the consumption of smoked Ethmalosa fimbriata poses a higher potential carcinogenic risk than the other fish species that were investigated. Most of the other studies on PAHs in smoked fish are focused on the smoking method, and little information is available on the initial level of PAHs prior to the smoking process. Metal contamination in fish appeared to be affected by mineral deposits in the environment and industrial effluents. In general, heavy metal levels in fish are below the maximum levels, while there is limited data available on POPs of relevance to food safety in fish from Nigeria, particularly in terms of dioxins, brominated flame retardants, and fluorinated compounds. Furthermore, there is currently limited information on the levels of microplastics in fish from Nigerian waters. This work revealed the need for a more systematic sampling strategy for fish in order to identify the most vulnerable species, the hot spots of contaminants, and applicable food safety control measures for fish produced and consumed in Nigeria.

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Gonado-histopathological changes, intersex and endocrine disruptor responses in relation to contaminant burden in Tilapia species from Ogun River, Nigeria

Cited by 29 publications

References 55 publications

Neurotoxicity of a Biopesticide Analog on Zebrafish Larvae at Nanomolar Concentrations

Neurotoxicity of a Biopesticide Analog on Zebrafish Larvae at Nanomolar Concentrations

Biomonitoring of aquatic pollution: status and trends from genomics to populations

A Review of Chemical Contaminants in Marine and Fresh Water Fish in Nigeria

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