Gonadotropin Alone is a Better Drug for Ovarian Stimulation than in Combination with Clomiphene in Intrauterine Insemination

Sinha, Sushma; Agrawal, Neha

doi:10.1007/s13224-015-0686-9

Cited by 2 publications

(3 citation statements)

References 15 publications

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“…The reported total CPR was 28.9% and ectopic and multiple pregnancy rates were 2% and 3.9%, respectively, with an abortion rate of 3.3%; so net CPR was 24.3%. In line with these figures, Irani et al [18] , Sinha and Agrawal [19] , Hembram et al [21] and Banker et al [22] reported pregnancy rates of 17.8%, 18.9%, 23.3% and 14.55%, respectively, with a miscarriage rate 5.43% [22] .…”

Section: Discussionmentioning

confidence: 71%

“…The applied OS protocol consisted of 5-days course of daily oral CC (100 mg) since day-3 of the menstrual cycle, then daily injection of human menopausal gonadotropin (GN; 150 IU) starting on day-8 until hCG administration. Review of literature showed contradictory outcomes concerning CC +GN or GN alone where Sinha and Agrawal [19] reported that GN alone appears to give better results than CC + GN, but combination is cost-effective. Moreover, Kamath et al [20] after a meta-analysis of published studies reported no conclusive evidence indicating that CC with or without GN differed from GN in GnRH agonist or antagonist protocols, but the use of CC led to a reduction in the amount of GN required and the incidence of OHSS.…”

Section: Discussionmentioning

confidence: 99%

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Prospective comparative trial to define the optimum time for insemination during stimulated intrauterine insemination cycles

El-Kallaf

2018

Evidence Based Women's Health Journal

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Objectives: To determine the clinical pregnancy rate (CPR) of women who underwent clomiphene citrate (CC) and human menopausal gonadotropin ovarian stimulation (OS) followed by intrauterine insemination (IUI) at varied times after hCG ovulation triggering and to determine the appropriate IUI timing. Patients and Methods: 152 women with primary infertility secondary to male subfertility were randomly allocated into groups (I-IV) according to timing of IUI at 34-35, 35-36, 36-37, and 37-38hr after ovulation triggering. OS consisted of 5-days oral CC 100 mg once daily since day-3 of the menstrual cycle followed by daily injection of human menopausal gonadotropin 150 IU since day-8 until hCG injection. Ovulation was monitored using TVU for evident ovulation with a dominant follicle size >18 mm. IUI was repeated for three cycles and women were evaluated for clinical pregnancy rate (CPR) and abortion and multiple pregnancy rates were recorded. Results: 44 women had clinical pregnancy for a total CPR of 28.9%. CPR% /patient was 15.8%, 34.2%, 42.1% and 23.7% and CPR%/cycle was 6, 14, 20 and 11 in the four groups, respectively with significant differences in favor of group III. Three women had ectopic and six women had multiple pregnancy and five women had abortion. Statistical analyses defined high number of performed IUI cycles as significantly negative, while longer time till IUI after hCG injection as significantly positive predictor for trial success. Kaplan-Meier regression analysis defined 37 hr (95% CI: 36.5-37.5) after hCG injection as the appropriate time to get the best chance for IUI success. Conclusion: IUI after CC + GN ovarian stimulation is an appropriate policy for infertile couples secondary to male subfertility. Total motile sperm count threshold at ≥5 million gives acceptable outcome. Semen injection at 37 hr after hCG ovulation triggering gives the highest CPR.

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Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Prospective comparative trial to define the optimum time for insemination during stimulated intrauterine insemination cycles

El-Kallaf

2018

Evidence Based Women's Health Journal

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“…Estima-se que, atualmente, há cerca de dois milhões de bebês nascidos no mundo através da FIV, uma técnica que tem demonstrado um aumento excelente e progressivo nas taxas de sucesso, possibilitando que casais inférteis, homoafetivos e pessoa solo tenham a chance de se tornarem pais. Com os avanços na tecnologia da FIV e a injeção intracitoplasmática de espermatozoides (ICSI) houve um aumento do sucesso na RHA, contribuindo para que mulheres com infertilidade aumentem a chance de engravidar (Sinha et al, 2015).…”

Section: A Utilização Da Fiv Na Reprodução Humanaunclassified

Impacto da microbiota uterina na reprodução assistida: revisão de literatura

Silva

Dutra

Sales-Moioli³

et al. 2022

RSD

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Os microrganismos presentes no sistema reprodutor feminino, principalmente no útero, podem ser responsáveis por infertilidade em algumas mulheres, e até mesmo pelo insucesso nos ciclos de fertilização in vitro (FIV). Entretanto, esse assunto é pouco explorado na área clínica e a literatura acerca desse tema ainda é escassa. Tendo em vista essa problemática, o objetivo dessa revisão foi relacionar a importância da microbiota uterina para o sucesso da reprodução humana. Sabe-se que a microbiota do trato reprodutor feminino é habitada por diversos microrganismos, dentre eles os Lactobacillus. A quantidade de espécies presentes no local está relacionada com a saúde da mulher e a diversos fatores como, oscilações hormonais e idade, por exemplo. Dependendo da composição bacteriana presente no sistema reprodutor feminino, a mulher poderá desenvolver diversos problemas, como infecções, que podem apresentar sintomas e dificuldades em conceber uma gravidez. Existem muitos estudos que apontam a relação do equilíbrio da microbiota do trato reprodutivo ser fundamental no sucesso da reprodução humana, porém não há um entendimento profundo nesse sentido. Pesquisas futuras deverão buscar descobrir com mais detalhes as interações entre a microbiota vaginal e uterina e, assim, possibilitar intervenções significativas para melhorar a fertilidade resultado do tratamento.

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Gonadotropin Alone is a Better Drug for Ovarian Stimulation than in Combination with Clomiphene in Intrauterine Insemination

Abstract: Significant differences in pregnancy rates and endometrial thickness were seen. Gonadotropin alone thus appears to give better results, but CC + Gonadotropin seems to be a cost-effective drug.

Cited by 2 publications

References 15 publications

Prospective comparative trial to define the optimum time for insemination during stimulated intrauterine insemination cycles

Prospective comparative trial to define the optimum time for insemination during stimulated intrauterine insemination cycles

Impacto da microbiota uterina na reprodução assistida: revisão de literatura

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