Gonadotropin-inhibiting hormone stimulates feeding behavior in chicks

Tachibana, Tetsuya; Sato, Miyako; Takahashi, Hirokazu; Ukena, Kazuyoshi; Tsutsui, Kazuyoshi; Furuse, Mitsuhiro

doi:10.1016/j.brainres.2005.05.035

Cited by 120 publications

(88 citation statements)

References 26 publications

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“…Conversely, central injections of galanin-like peptide (GALP) decrease food intake and body weight (Krasnow, Fraley, Schuh, Baumgartner, Clifton, and Steiner, 2003;Seth, Stanley, Dhillo, Murphy, Ghatei, and Bloom, 2003), but stimulate sex behavior and LH secretion in male rats (Fraley, Thomas-Smith, Acohido, Steiner, and Clifton, 2004;Krasnow et al, 2003). The results of this current study show that rat RFRP-3 fits into this hypothalamic motif; RFRP-3 suppresses sex behavior while increasing food intake-similarly to that observed in the chick (Tachibana, Sato, Takahashi, Ukena, Tsutsui, and Furuse, 2005). These observations bolster our opinion that rat RFRP-3 is another important hypothalamic neuropeptide involved in maintaining homeostasis between reproduction and metabolism.…”

Section: Discussionsupporting

confidence: 64%

Rat RFamide-related peptide-3 stimulates GH secretion, inhibits LH secretion, and has variable effects on sex behavior in the adult male rat

Johnson

Tsutsui

Fraley

2007

Hormones and Behavior

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352

383

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A recently described avian neuropeptide, gonadotropin inhibitory hormone (GnIH), has been shown to have seasonal regulatory effects on the hypothalamic-pituitary-gonadotropin axis (HPG) in several avian species. In the bird, GnIH expression is increased during the photorefractory period and has inhibitory effects on the HPG. A recently described mammalian neuropeptide, RF-amide-related peptide-3 (RFRP-3), may be genetically related and functionally similar to this avian neuropeptide. The purposes of this study were to first see if rat RFRP-3 is expressed in the male rat brain and second to determine if ICV injections of RFRP-3 will have effects on feeding and sex behaviors, as well as hormone release from the anterior pituitary. Results confirm other studies in that immunoreactive cell bodies and fibers are observable in areas of the male rat brain known to control the HPG and feeding and sex behaviors. RFRP-3 fibers are also observed in close proximity to GnRH immunoreactive cell bodies. Behavioral tests indicate that high but not low ICV RFRP-3 (500 vs. 100 ng, respectively) significantly (p < 0.05) suppressed all facets of male sex behavior while not having any observable effects on their ability to ambulate. Sex behavior was later exhibited when those same male rats received the ICV vehicle. While suppressing sex behavior, ICV RFRP-3 significantly (p < 0.05) increased food intake compared to controls. ICV RFRP-3 also significantly reduced plasma levels of luteinizing hormone but increased growth hormone regardless of the time of day; however, at no time did RFRP-3 alter plasma levels of FSH, thyroid hormone, or cortisol. These results indicate that although RFRP-3 has similar effects on LH as observed with GnIH in avian species, in the rat RFRP-3 has additional roles in regulating feeding and growth.

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Section: Discussionsupporting

confidence: 64%

Rat RFamide-related peptide-3 stimulates GH secretion, inhibits LH secretion, and has variable effects on sex behavior in the adult male rat

Johnson

Tsutsui

Fraley

2007

Hormones and Behavior

Self Cite

352

383

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“…RFamide-related peptides (RFRPs) homologous to GnIH and its receptors have previously been identified in rats and mice (Hinuma et al 2000, Ukena et al 2002. The extensive distribution of GnIH-ir fibers in the multiple brain areas is consistent with multiple functions of GnIH such as feeding behavior in chickens (Tachibana et al 2005) and sexual behavior in white-crowned sparrows . GnIH-ir neurons were found to have close appositions with GnRH-ir cells suggesting a possible interaction of GnIH and GnRH neurons (Kriegsfeld et al 2006).…”

Section: Introductionmentioning

confidence: 77%

Gonadotropin-inhibitory hormone (GnIH) receptor gene is expressed in the chicken ovary: potential role of GnIH in follicular maturation

et al. 2008

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Gonadotropin-inhibitory hormone (GnIH), an RFamide peptide, has been found to inhibit pituitary LH secretion in avian and mammalian species. The gene encoding a putative receptor for GnIH (GnIHR) was recently identified in the chicken and Japanese quail brain and pituitary gland. GnIHR appears to be a seven-transmembrane protein belonging to a family of G-protein-coupled receptors. In the present study, we have characterized the expression of GnIHR mRNA in the chicken ovary and demonstrate that GnIHR may exert an inhibitory effect on ovarian follicular development. By RT-PCR, we detected GnIHR mRNA in the chicken testis and in the ovary, specifically both thecal and granulosa cell layers. Real-time quantitative PCR analysis revealed greater GnIHR mRNA quantity in theca cells of prehierarchial follicles compared with that of preovulatory follicles. GnIHR mRNA quantity was significantly decreased in sexually mature chicken ovaries versus ovaries of sexually immature chickens. Estradiol (E 2 ) and/or progesterone (P 4 ) treatment of sexually immature chickens significantly decreased ovarian GnIHR mRNA abundance. Treatment of prehierarchial follicular granulosa cells in vitro with chicken GnIH peptide significantly decreased basal but not FSH-stimulated cellular viability. Collectively, our results indicate that the ovarian GnIHR is likely to be involved in ovarian follicular development. A decrease in ovarian GnIHR mRNA abundance due to sexual maturation or by E 2 and/or P 4 treatment would implicate an inhibitory role for GnIHR in ovarian follicular development. Furthermore, GnIH may affect follicular maturation by decreasing the viability of prehierarchial follicular granulosa cells through binding to GnIHR.

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“…leptin; Castellano et al 2005Castellano et al , 2006bSmith et al 2006;Luque et al 2007). Recent evidence suggests that GnIH may interact with the ingestive system in chickens and rats, with injections of GnIH leading to a significant increase in feeding behaviour (Tachibana et al 2005;Johnson et al 2007). Thus, it is likely that seasonal breeders respond not only to photoperiodic cues, but also to supplementary cues that allow for adjustments of the kisspeptin and GnIH systems in response to real-time changes in energy availability.…”

Section: Future Directionsmentioning

confidence: 99%

Recent advances in reproductive neuroendocrinology: a role for RFamide peptides in seasonal reproduction?

et al. 2008

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Most temperate-zone species use photoperiod to coordinate breeding and ensure that offspring are born during favourable conditions. Although photoperiodic influences on the reproductive axis have been well characterized, the precise mechanisms by which photoperiodic information and other seasonal cues are integrated to regulate reproductive function remain less well specified. Two recently discovered neuropeptides, kisspeptin and gonadotropin-inhibitory hormone, have pronounced opposing influences on reproductive function. This paper will review recent evidence for a role of these peptides in seasonal reproduction and propose a theoretical framework by which these novel regulatory peptides may serve to regulate seasonal breeding. Understanding the mechanisms regulating appropriate changes in reproductive status will serve to advance a wide range of life science disciplines.

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Gonadotropin-inhibiting hormone stimulates feeding behavior in chicks

Cited by 120 publications

References 26 publications

Rat RFamide-related peptide-3 stimulates GH secretion, inhibits LH secretion, and has variable effects on sex behavior in the adult male rat

Rat RFamide-related peptide-3 stimulates GH secretion, inhibits LH secretion, and has variable effects on sex behavior in the adult male rat

Gonadotropin-inhibitory hormone (GnIH) receptor gene is expressed in the chicken ovary: potential role of GnIH in follicular maturation

Recent advances in reproductive neuroendocrinology: a role for RFamide peptides in seasonal reproduction?

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