Gonadotropins and Their Association with the Risk of Prediabetes and Type 2 Diabetes in Middle-Aged Postmenopausal Women

Stefańska, Anna; Cembrowska, Paulina; Kubacka, Justyna; Kuligowska-Prusińska, Magdalena; Sypniewska, Grażyna

doi:10.1155/2019/2384069

Cited by 20 publications

(16 citation statements)

References 30 publications

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“…Further analysis showed that FSH was independently associated with the LAR in our postmenopausal women. Taken together, our results support that a higher FSH level was associated with lowering insulin resistance and diabetes in postmenopausal women [ 10 , 19 ].…”

Section: Discussionsupporting

confidence: 83%

“…FSH was significantly associated with adiponectin levels in the non-BrCa group ( p < 0.001) after adjusting for age, BMI, and menopause duration. These results indicate that adiponectin might be a link between FSH and metabolic disorders, such as insulin resistance and prediabetes, in postmenopausal women [ 10 , 19 ].…”

Section: Discussionmentioning

confidence: 99%

“…The findings from The Study of Women’s Health Across the Nation (SWAN) demonstrated that serum FSH level is associated with body weight gain and increased visceral adiposity [ 9 ]. Further studies reported that FSH is negatively associated with fasting glucose levels and glycated hemoglobin as well as with a higher prevalence of prediabetes and diabetes in postmenopausal women [ 10 , 11 ]. These results suggest that FSH might be associated with adiposity and insulin resistance.…”

Section: Introductionmentioning

confidence: 99%

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Relationships between Follicle-Stimulating Hormone and Adiponectin in Postmenopausal Women

Huang¹,

Chen

Kor

et al. 2020

Metabolites

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Beyond fertility, follicle-stimulating hormone (FSH) may exert action on adipocytes, which are the major source of adiponectin and leptin, linking to insulin resistance. Therefore, we evaluated the relationships between FSH and adipocyte-derived hormones. This cross-sectional study enrolled postmenopausal women aged 40–65 years. The variables measured in this study included clinical parameters, fasting levels of sex hormones, glucose, insulin, and adipokines. A total of 261 women without breast cancer, 88 women with breast cancer receiving tamoxifen, and 59 women with breast cancer receiving additional gonadotropin-releasing hormone analogs were enrolled in this study. Significant differences in the levels of adiponectin, leptin, and FSH were observed between the non-breast cancer group and the breast cancer groups. Spearman’s rank test revealed significant associations of FSH with either body mass index (BMI) or homeostatic model assessment of insulin resistance (HOMA-IR) values in the non-breast cancer group. After adjusting for BMI, age, and menopause duration, FSH levels were significantly associated with adiponectin (p < 0.001) and the leptin-to-adiponectin ratio (p = 0.008) in the non-breast cancer group, but they were only significantly associated with adiponectin (p = 0.001) in the breast cancer group receiving tamoxifen. Our data show that FSH levels are independently associated with adiponectin levels in postmenopausal women, suggesting that adiponectin may link FSH to metabolic relationships in postmenopausal female.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Relationships between Follicle-Stimulating Hormone and Adiponectin in Postmenopausal Women

Huang¹,

Chen

Kor

et al. 2020

Metabolites

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“…As previous studies have demonstrated that prediabetes was an impaired glucose regulation state which mainly caused by the pancreatic β cell dysfunction with insulin secretion and hepatic insulin resistance (IR) cell damage [ 19 , 20 ]. Besides, people with prediabetes have a high risk of developing diabetes mellitus, especially T2DM [ 21 ]. Numerous researches have indicated that PI, TI, 25(OH) D3, and WC were associated with the occurrence of T2DM [ 5 , 22 – 25 ].…”

Section: Discussionmentioning

confidence: 99%

The correlation between proinsulin, true insulin, proinsulin: True insulin ratio, 25(OH) D3, waist circumference and risk of prediabetes in Hainan Han adults

et al. 2020

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Diabetes mellitus is a kind of highly prevalent chronic disease in the world. The intervention measures on the risk factors of prediabetes contribute to control and reduce the occurrence of diabetes. This study aimed to investigate the correlation between proinsulin (PI), true insulin (TI), PI/TI, 25(OH) D3, waist circumference (WC), and risk of prediabetes. Methods In this cross-sectional study, 1662 subjects including 615 prediabetes and 1047 non-prediabetes were recruited. Spearman's correlation analysis was used to explore the association of PI, TI, PI/TI, 25(OH) D3, and waist circumference with prediabetes. Odds ratios (OR) and 95% confidence intervals (CI) were calculated by logistic regression. Receiver-Operator Characteristic (ROC) curve was used to evaluate the risk of prediabetes. Results Our study showed that FPI, 2hPI, FTI, 2hTI, FPI/FTI, and WC could enhance the risk of prediabetes (OR 1.034; OR 1.007; OR 1.005; OR 1.002; OR 3.577, OR 1.053, respectively; all p< 0.001). Stratified analyses indicated that FPI/FTI associated with an increased risk of prediabetes in men (OR 2.080, p = 0.042). FTI have a weak association with prediabetes risk in men and women (OR 0.987, p = 0.001; OR 0.994, p = 0.004, respectively). 2hPI could decrease prediabetes in women (OR 0.995, p = 0.037). Interesting, the sensitivity (86.0%) and AUC (0.942, p< 0.001) of combination (FPI+FTI+2hPI+2hTI+25(OH) D3+WC) were higher than the diagnostic value of these alone diagnoses. The optimal cutoff point of FPI, FTI, 2hPI, 2hTI, 25(OH) D3, and WC for indicating prediabetes were 15.

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“…showed that low levels of FSH are associated with increased risk of metabolic abnormalities in postmenopausal women. [ 42 ] The possible reasons are, the higher estrogen in obese postmenopausal women leading to aromatization of androgens to estrogens in adipose tissue, which suppresses FSH secretion. In addition, other compounds such as follistatin and activin may influence the FSH level and simultaneously regulate insulin sensitivity and chronic inflammatory status.…”

Section: B Ackgroundmentioning

confidence: 99%

On psychology and psychiatry in diabetes

Sridhar¹

2020

Indian J Endocr Metab

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Managing diabetes requires dealing with diet, medications, and self-monitoring, besides other pressures of daily living. It, therefore, requires collaboration among individuals with diabetes, their families, and significant others including the social milieu in which they reside. Psychological stress plays critical role in the cause and course of diabetes, particularly in mastering various self-management skills, which are essential for adequate management of diabetes. It is possible to measure and to resolve such stressors. Besides the patient and the family, the built environment which the person occupies must be conducive for healthy living. This is a key component in providing an appropriate physical and psychosocial environment. Lacunae in any of the built environmental parameters compromise social and psychological well-being. Psychiatric conditions are also common in diabetes. Both depression and distress are bi-directionally associated with diabetes. The presence of one condition increases the risk of developing the other. In addition, medications used for the treatment of psychiatric conditions have adverse effects on body weight and insulin sensitivity. One must carefully weigh the risk and benefit of the drug class with potential adverse effects. Therefore, identification and management of psychological and psyciatric aspects in subjects with diabetes is an integral and critical component in treating subjects with diabetes.

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Gonadotropins and Their Association with the Risk of Prediabetes and Type 2 Diabetes in Middle-Aged Postmenopausal Women

Cited by 20 publications

References 30 publications

Relationships between Follicle-Stimulating Hormone and Adiponectin in Postmenopausal Women

Relationships between Follicle-Stimulating Hormone and Adiponectin in Postmenopausal Women

The correlation between proinsulin, true insulin, proinsulin: True insulin ratio, 25(OH) D3, waist circumference and risk of prediabetes in Hainan Han adults

On psychology and psychiatry in diabetes

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